Zobrazeno 1 - 10
of 210
pro vyhledávání: '"L, McCain"'
Autor:
Mher Garibyan, Tyler Hoffman, Thijs Makaske, Stephanie K. Do, Yifan Wu, Brian A. Williams, Alexander R. March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson, Jeffrey W. Santoso, Ali Khademhosseini, Matt Thomson, Song Li, Megan L. McCain, Leonardo Morsut
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors that enable mammalian cells to detect environmental signals and respond by activating user-prescribed transcriptional programs. Although some materials
Externí odkaz:
https://doaj.org/article/7b52332128de4f3eaab5e1d7a7349b0e
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100080- (2024)
Myocardial infarction (MI) causes hypoxic injury to downstream myocardial tissue, which initiates a wound healing response that replaces injured myocardial tissue with a scar. Wound healing is a complex process that consists of multiple phases, in wh
Externí odkaz:
https://doaj.org/article/598553c0b4d84186ac2aa57e2f8a86be
Autor:
Mher Garibyan, Tyler Hoffman, Thijs Makaske, Stephanie K. Do, Yifan Wu, Brian A. Williams, Alexander R. March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson, Jeffrey W. Santoso, Ali Khademhosseini, Matt Thomson, Song Li, Megan L. McCain, Leonardo Morsut
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c53f5253835a499695a52fb2a466a8ee
Autor:
Natalie N. Khalil, Andrew P. Petersen, Cheng J. Song, Yibu Chen, Kaelyn Takamoto, Austin C. Kellogg, Elaine Zhelan Chen, Andrew P. McMahon, Megan L. McCain
Publikováno v:
APL Bioengineering, Vol 7, Iss 3, Pp 036106-036106-10 (2023)
Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited relevance of pre-clinical models of the proximal tubule. Culturing proximal tubule epithelial cells (PTECs) under fluid flow to mimic physiological shear stre
Externí odkaz:
https://doaj.org/article/2102ffe3666e4b4db2feed8152640442
Publikováno v:
Current Research in Physiology, Vol 6, Iss , Pp 100108- (2023)
The uterus is susceptible to benign tumors known as fibroids, which have been associated with many pregnancy complications, including preterm labor. However, the impact of fibrotic tissue remodeling on the physiology of the myometrium, the smooth mus
Externí odkaz:
https://doaj.org/article/c3b4f3dc5b0742a4890dea195f43a391
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/0592ebddb3a04085ba4c0517340359a7
Autor:
Florian Barthélémy, Jeffrey W. Santoso, Laura Rabichow, Rongcheng Jin, Isaiah Little, Stanley F. Nelson, Megan L. McCain, M. Carrie Miceli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In vitro models of patient-derived muscle allow for more efficient development of genetic medicines for the muscular dystrophies, which often present mutation-specific pathologies. One popular strategy to generate patient-specific myotubes involves r
Externí odkaz:
https://doaj.org/article/73fc79b089c845ef877ae95d996f78e5
Autor:
Jeffrey W. Santoso, Xiling Li, Divya Gupta, Gio C. Suh, Eric Hendricks, Shaoyu Lin, Sarah Perry, Justin K. Ichida, Dion Dickman, Megan L. McCain
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 036101-036101-16 (2021)
To develop effective cures for neuromuscular diseases, human-relevant in vitro models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture motor neurons
Externí odkaz:
https://doaj.org/article/6fd450d7c35443ed846926f94cea84d9
Autor:
Natalie N. Khalil, Megan L. McCain
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Myocardial infarctions are one of the most common forms of cardiac injury and death worldwide. Infarctions cause immediate necrosis in a localized region of the myocardium, which is followed by a repair process with inflammatory, proliferative, and m
Externí odkaz:
https://doaj.org/article/9cd8d46cfa914e49ad627da10d4c3a8d
Autor:
Jeffrey W. Santoso, Megan L. McCain
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to engineer cells into microscale tissues with native-like features and then extract physiologically relevant readouts at scale. Because they are generally compatible
Externí odkaz:
https://doaj.org/article/06ef44b2229d415188a7be9f5322d53c