Zobrazeno 1 - 10
of 2 302
pro vyhledávání: '"L, Masters"'
Autor:
Léonie Borne, Renate Thienel, Michelle K. Lupton, Christine Guo, Philip Mosley, Anna Behler, Joseph Giorgio, Robert Adam, Amelia Ceslis, Pierrick Bourgeat, Amir Fazlollahi, Paul Maruff, Christopher C. Rowe, Colin L. Masters, Jurgen Fripp, Gail A. Robinson, Michael Breakspear
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Deficits in memory are seen as a canonical sign of aging and a prodrome to dementia in older adults. However, our understanding of age-related cognition and brain morphology occurring throughout a broader spectrum of adulthood remains limite
Externí odkaz:
https://doaj.org/article/a7e8d0a960f341259f3bfca57dd0ef4d
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A. Perez, Céline Dubois, Yen Y. Lim, Candace Drysdale, Rebecca L. Rumble, Holly R. Chinnery, Christopher C. Rowe, Ralph N. Martins, Paul Maruff, James D. Doecke, Yong Lin, Abdel A. Belaidi, Kevin J. Barnham, Colin L. Masters, Ben J. Gu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to
Externí odkaz:
https://doaj.org/article/3d0335505eb94001ae1c6a1edbac7289
Autor:
Elina Idiiatullina, Mahmoud Al-Azab, Meng Lin, Katja Hrovat-Schaale, Ziyang Liu, Xiaotian Li, Caiqin Guo, Xixi Chen, Yaoying Li, Song Gao, Jun Cui, Wenhao Zhou, Li Liu, Yuxia Zhang, Seth L. Masters
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mitochondrial RNA (mtRNA) in the cytosol can trigger the innate immune sensor MDA5, and autoinflammatory disease due to type I IFN. Here, we show that a dominant negative mutation in the gene encoding the mitochondrial exonuclease REXO2 may
Externí odkaz:
https://doaj.org/article/0032191b7af148eb845c8a3117450786
Autor:
Yihan Wang, Shu Liu, Alanna G. Spiteri, Andrew Liem Hieu Huynh, Chenyin Chu, Colin L. Masters, Benjamin Goudey, Yijun Pan, Liang Jin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Several (inter)national longitudinal dementia observational datasets encompassing demographic information, neuroimaging, biomarkers, neuropsychological evaluations, and muti-omics data, have ushered in a new era of potential for integrating
Externí odkaz:
https://doaj.org/article/eefdc1e7f56e408da1410a2f95024c8a
Autor:
Dhamidhu Eratne, Steven Collins, Peter J. Nestor, Dimity Pond, Dennis Velakoulis, Mark Yates, Colin L. Masters
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Cerebrospinal fluid (CSF) biomarkers are currently the only clinically validated biofluid diagnostic test for Alzheimer’s Disease (AD) available in Australia. Testing of CSF biomarkers via lumbar puncture (LP), including quantification of amyloid-
Externí odkaz:
https://doaj.org/article/c4d81795137742ac8f2486f757a176d2
Autor:
Yijun Pan, Chenyin Chu, Yifei Wang, Yihan Wang, Guangyan Ji, Colin L. Masters, Benjamin Goudey, Liang Jin
Publikováno v:
EClinicalMedicine, Vol 76, Iss , Pp 102834- (2024)
Summary: Background: It is estimated that ∼60% of people with Alzheimer's disease (AD) are undetected or undiagnosed, with higher rates of underdiagnosis in low-to middle-income areas with limited medical resources. To promote health equity, we hav
Externí odkaz:
https://doaj.org/article/bd53fa5b9f7c4c4aa85db13d83e65e51
Autor:
Liwei Ma, Edwin C. K. Tan, Ashley I. Bush, Colin L. Masters, Benjamin Goudey, Liang Jin, Yijun Pan, AIBL Research Group
Publikováno v:
Journal of Epidemiology and Global Health, Vol 14, Iss 3, Pp 1130-1141 (2024)
Abstract Background The associations between mood disorders (anxiety and depression) and mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) remain unclear. Methods Data from the Australian Imaging, Biomarker & Lifestyle (AIBL) study were
Externí odkaz:
https://doaj.org/article/dd74eadef35446cd963c3f923eed17ec
Autor:
Liwei Ma, Yi Ling Clare Low, Yuanhao Zhuo, Chenyin Chu, Yihan Wang, Christopher J. Fowler, Edwin C. K. Tan, Colin L. Masters, Liang Jin, Yijun Pan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract An inverse association between cancer and Alzheimer’s disease (AD) has been demonstrated; however, the association between cancer and mild cognitive impairment (MCI), and the association between cancer and cognitive decline are yet to be c
Externí odkaz:
https://doaj.org/article/69185a15744047ecae83cc500a52be73