Zobrazeno 1 - 10
of 219
pro vyhledávání: '"L, Malspeis"'
Autor:
D, Marcantonio, L C, Panasci, M G, Hollingshead, M C, Alley, R F, Camalier, E A, Sausville, D J, Dykes, C A, Carter, L, Malspeis
Publikováno v:
Cancer research. 57(18)
Nitrosoureas are among the most widely used agents used in the treatment of malignant gliomas. Here, the activity of 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) was compared with that of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0776c11d9f5cefa6aaf468d1933fea40
https://pubmed.ncbi.nlm.nih.gov/9307267
https://pubmed.ncbi.nlm.nih.gov/9307267
Autor:
M, Drees, W A, Dengler, T, Roth, H, Labonte, J, Mayo, L, Malspeis, M, Grever, E A, Sausville, H H, Fiebig
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(2)
We have selected a panel of human tumor xenografts for in vitro and in vivo studies that allows an indication of selectivity of action of novel chemotherapeutic agents. We report here the antitumor activity of the flavone flavopiridol (previously des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0e6be28dce02fcc3c123cfd7c169547
https://pubmed.ncbi.nlm.nih.gov/9815683
https://pubmed.ncbi.nlm.nih.gov/9815683
Autor:
E A, Sausville, K L, Duncan, A, Senderowicz, J, Plowman, P A, Randazzo, R, Kahn, L, Malspeis, M R, Grever
Publikováno v:
The cancer journal from Scientific American. 2(1)
An empiric in vitro screen of human tumor cell lines found brefeldin A inhibited the growth of immortalized human cell lines, with particular sensitivity to brefeldin in a series of immortalized melanoma cell lines and nonimmortalized prostate carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03433d40d3eb0baeb3624eb56754012b
https://pubmed.ncbi.nlm.nih.gov/9166499
https://pubmed.ncbi.nlm.nih.gov/9166499
Publikováno v:
Cancer research. 55(13)
[(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile] (AG17), a "tyrphostin" tyrosine kinase antagonist, was found to inhibit tumor cell growth with 50% growth inhibition ranging from 0.7 to 4.0 microM in a panel of 13 human tumor cell lines, as e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebedddd81dae4a6520a90560ebe6ed2e
https://pubmed.ncbi.nlm.nih.gov/7796405
https://pubmed.ncbi.nlm.nih.gov/7796405
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(7)
The monocyclic terpene d-limonene, a major component in many citrus essential oils (1-3), has been used for many years as a flavoring agent, food additive, and fragrance (1, 2). It was recently demonstrated that limonene exhibits both chemopreventive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05b100e05e12ba2f907d0c1e61eb4f8d
https://pubmed.ncbi.nlm.nih.gov/7587953
https://pubmed.ncbi.nlm.nih.gov/7587953
Autor:
J G, Supko, L, Malspeis
Publikováno v:
Cancer research. 53(13)
Although 20(S)-camptothecin (CA) exhibited potent cytotoxicity against a broad spectrum of tumor models, clinical trials with the sodium salt of its opened lactone ring form were discontinued due to highly variable and severe toxicity. Recently, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aca034356f5d61c8e085d3106d7f0bbd
https://pubmed.ncbi.nlm.nih.gov/8319213
https://pubmed.ncbi.nlm.nih.gov/8319213
Autor:
M, Grever, L, Malspeis
Publikováno v:
Hematology/oncology clinics of North America. 7(1)
Despite the major advances that have been made over the past few decades in the management of adult acute leukemia, a substantial number of the patients still die from the underlying disease. Therefore, it is essential that we vigorously pursue effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6c2a01bcb6376a5647ff5022ea85d28
https://pubmed.ncbi.nlm.nih.gov/8449860
https://pubmed.ncbi.nlm.nih.gov/8449860
Publikováno v:
Cancer research. 52(14)
Data generated in the new National Cancer Institute drug evaluation program, which are based on inhibition of cell growth in 60 human tumor cell lines, were probed with nine known antimitotic agents using the COMPARE algorithm. Cytotoxicity data were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe5e2802bc66e2f8d38e1a747f0fc65c
https://pubmed.ncbi.nlm.nih.gov/1617665
https://pubmed.ncbi.nlm.nih.gov/1617665
Publikováno v:
Cancer research. 52(13)
Therapeutic studies were conducted with L-histidinol, in combination with cyclophosphamide, bischloroethylnitrosourea, 5-fluorouracil, phenylalanine mustard, or cis-platinum(II)diammine dichloride, in several transplantable tumors in mice. These tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d8f26c2606b2b6c07630cdb4321c3df
https://pubmed.ncbi.nlm.nih.gov/1617631
https://pubmed.ncbi.nlm.nih.gov/1617631
Publikováno v:
The Journal of biological chemistry. 266(24)
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60 human tumor cell lines, were used to compare new compounds with agents of known mechanism of action in terms of their diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0a5dd62e5dfd1e53b56946d2a30337f
https://pubmed.ncbi.nlm.nih.gov/1874739
https://pubmed.ncbi.nlm.nih.gov/1874739