Zobrazeno 1 - 10
of 671
pro vyhledávání: '"L, Lorenzi"'
Autor:
Suet-Ying Kwan, Kristyn A. Gonzales, Mohamed A. Jamal, Heather L. Stevenson, Lin Tan, Philip L. Lorenzi, P. Andrew Futreal, Ernest T. Hawk, Joseph B. McCormick, Susan P. Fisher-Hoch, Robert R. Jenq, Laura Beretta
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The gut microbiota drives progression to liver fibrosis, the main determinant of mortality in metabolic dysfunction-associated steatohepatitis (MASH). In this study, we aimed to identify bacterial species associated with protection against liver fibr
Externí odkaz:
https://doaj.org/article/024dc3e0692f4057b109c7aedd234a0a
Autor:
Xin Li, Katherine Pham, Jazmin Ysaguirre, Iqbal Mahmud, Lin Tan, Bo Wei, Long J. Shao, Maryam Elizondo, Rabie Habib, Fathima Elizondo, Hiromi Sesaki, Philip L. Lorenzi, Kai Sun
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100633- (2024)
Dynamin-related protein 1 (DRP1) plays crucial roles in mitochondrial and peroxisome fission. However, the mechanisms underlying the functional regulation of DRP1 in adipose tissue during obesity remain unclear. To elucidate the metabolic and patholo
Externí odkaz:
https://doaj.org/article/69237537e4f44f5387e30146d971b8ae
Autor:
Hyemin Lee, Amber Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L. Lorenzi, Khandan Keyomarsi, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid
Externí odkaz:
https://doaj.org/article/8a9b82a867e747468ec49d729f1351db
Autor:
Sara Corvigno, Sunil Badal, Meredith L. Spradlin, Michael Keating, Igor Pereira, Elaine Stur, Emine Bayraktar, Katherine I. Foster, Nicholas W. Bateman, Waleed Barakat, Kathleen M. Darcy, Thomas P. Conrads, G. Larry Maxwell, Philip L. Lorenzi, Susan K. Lutgendorf, Yunfei Wen, Li Zhao, Premal H. Thaker, Michael J. Goodheart, Jinsong Liu, Nicole Fleming, Sanghoon Lee, Livia S. Eberlin, Anil K. Sood
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-26 (2023)
Abstract In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian ca
Externí odkaz:
https://doaj.org/article/6cd6335bee5943da92c6a3557efb08a7
Autor:
Steven W. Wall, Lilia Sanchez, Kelly Scribner Tuttle, Scott J. Pearson, Shivatheja Soma, Garhett L. Wyatt, Hannah N. Carter, Ramsey M. Jenschke, Lin Tan, Sara A. Martinez, Philip L. Lorenzi, Vishal M. Gohil, Monique Rijnkels, Weston W. Porter
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 5, Pp 1046-1063 (2023)
Abstract Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show that the breast tumor suppressor gene SIM2 promotes mitochondrial oxidative phosphory
Externí odkaz:
https://doaj.org/article/053db100e0644f5393e7cef5cb54595e
Autor:
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L. Rose, Sanjana Srinivasan, Shan Jiang, Q. Edward Chang, Ningping Feng, Jason P. Gay, Qi Wang, Jing Wang, Philip L. Lorenzi, Lucas J. Veillon, Bo Wei, John N. Weinstein, Angela K. Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A. Lyssiotis, Joseph R. Marszalek, Giulio F. Draetta, Haoqiang Ying
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumor growth and therapy resistance
Externí odkaz:
https://doaj.org/article/ef0f3fa470bc4ac8bab02e6b16959230
Autor:
Yongxing Wang, Vikram V Kulkarni, Jezreel Pantaleón García, Miguel M Leiva-Juárez, David L Goldblatt, Fahad Gulraiz, Lisandra Vila Ellis, Jichao Chen, Michael K Longmire, Sri Ramya Donepudi, Philip L Lorenzi, Hao Wang, Lee-Jun Wong, Michael J Tuvim, Scott E Evans
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011138 (2023)
Pneumonia is a worldwide threat, making discovery of novel means to combat lower respiratory tract infection an urgent need. Manipulating the lungs' intrinsic host defenses by therapeutic delivery of certain pathogen-associated molecular patterns pro
Externí odkaz:
https://doaj.org/article/b16611b4866742938bff92c35c629d1c
Autor:
Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S. K. Samanthapudi, Khanh Chau, Minh T. H. Nguyen, Jake Wen, Selina L. Hernandez Gonzalez, Shaefali P. Rodgers, Elizabeth A. Olmsted-Davis, Dale J. Hamilton, Cielito Reyes-Gibby, Sai-Ching J. Yeung, John P. Cooke, Joerg Herrmann, Eduardo N. Chini, Xiaolei Xu, Syed Wamique Yusuf, Momoko Yoshimoto, Philip L. Lorenzi, Brain Hobbs, Sunil Krishnan, Efstratios Koutroumpakis, Nicolas L. Palaskas, Guangyu Wang, Anita Deswal, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The “response-to-injury” model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis
Externí odkaz:
https://doaj.org/article/f88dfe27f863446b91fe021a59c753ff
Autor:
Gang Li, Xin Li, Iqbal Mahmud, Jazmin Ysaguirre, Baharan Fekry, Shuyue Wang, Bo Wei, Kristin L. Eckel-Mahan, Philip L. Lorenzi, Richard Lehner, Kai Sun
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Hepatocellular carcinoma (HCC) is the most common lethal form of liver cancer. Apart from surgical removal and transplantation, other treatments have not yet been well established for patients with HCC. In this study, we found that carboxylesterase 1
Externí odkaz:
https://doaj.org/article/de92de44d5f74854adf94990735933e3
Autor:
Peter M Masschelin, Pradip Saha, Scott A Ochsner, Aaron R Cox, Kang Ho Kim, Jessica B Felix, Robert Sharp, Xin Li, Lin Tan, Jun Hyoung Park, Liping Wang, Vasanta Putluri, Philip L Lorenzi, Alli M Nuotio-Antar, Zheng Sun, Benny Abraham Kaipparettu, Nagireddy Putluri, David D Moore, Scott A Summers, Neil J McKenna, Sean M Hartig
Publikováno v:
eLife, Vol 12 (2023)
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (
Externí odkaz:
https://doaj.org/article/efada387f39b4eff8fe4ccda1c65b1f6