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Strategies for Evaluation of Enveloped Virus Inactivation in Red Cell Concentrates Using Hypericin

Autor: A M, Prince, D, Pascual, D, Meruelo, L, Liebes, Y, Mazur, E, Dubovi, M, Mandel, G, Lavie

Publikováno v: Photochemistry and Photobiology. 71:188-195

Photodynamically induced virus inactivation appears promising in preventing transmission of enveloped virus infections in transfusible blood products. The potential for utilizing hypericin as a photosensitizer to inactivate key enveloped viruses in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb47e8b7f6f6a4dff2c4afc047d4f1f
https://doi.org/10.1562/0031-8655(2000)0710188sfeoev2.0.co2

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Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions

Autor: Franco M. Muggia, Janos Szebeni, L. Liebes, Sandor Savay, Asher Chanan-Khan, N. M. Rafique, Carl R. Alving

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 14(9)

Background: Pegylated liposomal doxorubicin (Doxil ® ) has been reported to cause immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type I) allergy. Previous in vitro and animal studies indicated that activation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5037d8bafff68051bd4e81b0782aa8de
https://pubmed.ncbi.nlm.nih.gov/12954584

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Randomized, placebo-controlled trial of dietary supplementation of alpha-tocopherol on mutagen sensitivity levels in melanoma patients: a pilot trial

Autor: Jonathan J. Lewis, Somdat Mahabir, L. Liebes, M. Nestle, D. Fry, Mary S. Brady, Daniel G. Coit, G C Roush, Marianne Berwick

Publikováno v: Melanoma research. 12(1)

We evaluated the effects of vitamin E (dl-alpha-tocopherol) on mutagen sensitivity levels in a randomized placebo-controlled pilot trial. In brief, a dietary supplement of 1000 mg/day vitamin E or a placebo was randomly administered for 3 months to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd66802456f2ce1b53b8408e772ad77
https://pubmed.ncbi.nlm.nih.gov/11828262

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Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli

Autor: Serkadis M. Getahun, Donald J. Pusateri, Debra K. W. Topham, María Botero-Omary, Leonard L. Liebes, Fung-Lung Chung, C. Clifford Conaway

Publikováno v: Nutrition and cancer. 38(2)

The cancer-chemopreventive effects of broccoli may be attributed, in part, to isothiocyanates (ITCs), hydrolysis products of glucosinolates. Glucosinolates are hydrolyzed to their respective ITCs by the enzyme myrosinase, which is inactivated by heat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f31e561f836ab77ac818d3d96cbc8fa
https://pubmed.ncbi.nlm.nih.gov/11525594

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Radiosensitization of tumor-targeted radioimmunotherapy with prolonged topotecan infusion in human breast cancer xenografts

Autor: B, Ng, E, Kramer, L, Liebes, C, Wasserheit, H, Hochster, E, Blank, R, Ceriani, P, Furmanski

Publikováno v: Cancer research. 61(7)

Clinical radioimmunotherapy (RIT) of solid tumors holds great promise, but as yet has been unable to deliver tumoricidal radiation doses without unacceptable toxicity. Our experimental approach aims to potentiate the therapeutic action of radioimmuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42faf33551ad5db115c86cce46b34807
https://pubmed.ncbi.nlm.nih.gov/11306478

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Activity and pharmacodynamics of 21-Day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy. New York Gynecologic Oncology Group

Autor: H, Hochster, S, Wadler, C, Runowicz, L, Liebes, H, Cohen, R, Wallach, J, Sorich, B, Taubes, J, Speyer

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 17(8)

Twenty-one-day topotecan infusion was administered as second-line therapy in patients with previously treated ovarian cancer (based on our prior favorable phase I experience) to determine its activity, time to progression, and pharmacodynamics.Ovaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::215205b7344e329d9aa036f53187b31d
https://pubmed.ncbi.nlm.nih.gov/10561322

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Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats

Autor: C C, Conaway, D, Jiao, T, Kohri, L, Liebes, F L, Chung

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(1)

Naturally occurring phenethyl isothiocyanate (PEITC) and its synthetic homolog 6-phenylhexyl isothiocyanate (PHITC) are both effective inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumor development in A/J mice and F344 ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e573a55d142c770e8bddd1f07a7c7872
https://pubmed.ncbi.nlm.nih.gov/9884304

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Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer

Autor: E L, Kramer, L, Liebes, C, Wasserheit, M E, Noz, E W, Blank, A, Zabalegui, J, Melamed, P, Furmanski, J A, Peterson, R L, Ceriani

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(7)

To evaluate radiometal-labeled humanized BrE-3 (huBrE-3) monoclonal antibody as a radioimmunolocalization and therapeutic agent in breast cancer patients, tumor localization, pharmacokinetics, radiation dosimetry, and immunogenicity of (111)In-labele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bed8a63f16a388c0ea147c352a097f81
https://pubmed.ncbi.nlm.nih.gov/9676842

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