Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome

Autor: Beatriz Marcos-Ramiro, Ana Gil-Ordóñez, Nagore I. Marín-Ramos, Francisco J. Ortega-Nogales, Moisés Balabasquer, Pilar Gonzalo, Nora Khiar-Fernández, Loïc Rolas, Anna Barkaway, Sussan Nourshargh, Vicente Andrés, Mar Martín-Fontecha, María L. López-Rodríguez, Silvia Ortega-Gutiérrez

Publikováno v: ACS Central Science, Vol 7, Iss 8, Pp 1300-1310 (2021)

Externí odkaz: https://doaj.org/article/e4776e931dc0449ea27758d4421817c1

Ligand chain length drives activation of lipid G protein-coupled receptors

Autor: Anastassia Troupiotis-Tsaïlaki, Julian Zachmann, Inés González-Gil, Angel Gonzalez, Silvia Ortega-Gutiérrez, Maria L. López-Rodríguez, Leonardo Pardo, Cedric Govaerts

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G protein-coupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic h

Externí odkaz: https://doaj.org/article/a21d0cf6f7474819a25877758a9730b9

Improvements in the learnability of smartphone haptic interfaces for visually impaired users.

Autor: F J González-Cañete, J L López Rodríguez, P M Galdón, A Díaz-Estrella

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225053 (2019)

We report the results of a study on the learnability of haptic icons used as alerts or notifications in smartphones. The aim was to explore the feasibility of using haptic icons to create assistive technologies for people with visual impairments. We

Externí odkaz: https://doaj.org/article/2ed0ae2667754ab9884aaa17a886877b

2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease

Autor: Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de los Frailes, Richard S. Roberts, Juan A. Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I. Loza, María L. López-Rodríguez

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname

Tolerance development caused by dopamine replacement with L-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson’s disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ee8cb90d20910f36acb8e932c24b4d
https://hdl.handle.net/10668/22592

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

Autor: Federico M. Ruiz, Andrea Escobar-Peña, María L. López-Rodríguez, José Manuel Andreu, Mar Martín-Fontecha, Sonia Huecas, Marta Artola, Henar Vázquez-Villa, Laura B. Ruiz-Avila, Lidia Araújo-Bazán, R Fernando Martínez, Carlos Fernández-Tornero

Publikováno v: Journal of Medicinal Chemistry
E-Prints Complutense. Archivo Institucional de la UCM
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC

51 p.-6 fig.-1 tab.-4 schem.-1 graph. abst.
Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of the bacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a36759cb16c566aab20dd465e9ef620
http://europepmc.org/articles/PMC8478281