Zobrazeno 1 - 10
of 505
pro vyhledávání: '"L, Kopp"'
Autor:
Elke Boxhammer, Matthias Hammerer, Christiana Schernthaner, Erika Prinz, Mathias C. Brandt, Michael Lichtenauer, Alexander E. Berezin, Wilfried Wintersteller, Uta C. Hoppe, Kristen L. Kopp
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2223 (2024)
Background: Prediabetes is frequently underdiagnosed and undertreated, yet it poses significant cardiovascular risks. This study investigates the impact of prediabetes on short- and long-term survival outcomes in patients who experienced ST-elevation
Externí odkaz:
https://doaj.org/article/fe1ae8217dc442c097c69462b2796503
Autor:
Kiyoshi Saeki, Ian S. Wood, Wei Chuan Kevin Wang, Shilpa Patil, Yanping Sun, David F. Schaeffer, Gloria H. Su, Janel L. Kopp
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101387- (2024)
Background & Aims: Pancreatic ductal adenocarcinoma can develop from precursor lesions, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN). Previous studies indicated that loss of Acvr1b accelerates the
Externí odkaz:
https://doaj.org/article/c27ef1153cab422c94a5c4539953f4d7
Autor:
Juan P. Zuniga-Hertz, Ramamurthy Chitteti, Joe Dispenza, Raphael Cuomo, Jacqueline A. Bonds, Elena L. Kopp, Sierra Simpson, Jonathan Okerblom, Svetlana Maurya, Brinda K. Rana, Atsushi Miyonahara, Ingrid R. Niesman, Jacqueline Maree, Gianna Belza, Hillari D. Hamilton, Carla Stanton, David J. Gonzalez, Michelle A. Poirier, Tobias Moeller-Bertram, Hemal H. Patel
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 32, Iss , Pp 100675- (2023)
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while alternative approaches such as meditation, shown to improve immunity, have been largely un
Externí odkaz:
https://doaj.org/article/dfbdeaceac4345899555a7cf3860a8bb
Autor:
Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels. Cell aggregation is essential for islet endocrine function; however, it remains unclear how
Externí odkaz:
https://doaj.org/article/1af8a5ad4f5e48b9ad89b0e0e5e6d997
Autor:
Elena L. Kopp, Daniel N. Deussen, Raphael Cuomo, Reinhard Lorenz, David M. Roth, Sushil K. Mahata, Hemal H. Patel
Publikováno v:
Cells, Vol 12, Iss 24, p 2786 (2023)
Type 2 diabetes (T2D) has a complex pathophysiology which makes modeling the disease difficult. We aimed to develop a novel model for simulating T2D in vitro, including hyperglycemia, hyperlipidemia, and variably elevated insulin levels targeting mus
Externí odkaz:
https://doaj.org/article/e19c7bd6e49641b7a54de4fd681033b0
Autor:
Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Janel L. Kopp
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial neop
Externí odkaz:
https://doaj.org/article/ff9b541c39684bccacb601c1a9c7f635
Autor:
Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101667- (2023)
Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression. IAPP has been reported to act as a
Externí odkaz:
https://doaj.org/article/3b960dd09db649a3b0d27836178a6bad
Autor:
Inés Lecoq, Katharina L. Kopp, Marion Chapellier, Panagiotis Mantas, Evelina Martinenaite, Maria Perez-Penco, Lars Rønn Olsen, Mai-Britt Zocca, Ayako Wakatsuki Pedersen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis. CCL22 was shown to play a key role in suppressing anti-cancer immune responses in different cancer types. Recently, we showed that
Externí odkaz:
https://doaj.org/article/4deb28186bcd4fa28e4ce8cd2df20145
Publikováno v:
Diabetes & Metabolism Journal, Vol 45, Iss 3, Pp 285-311 (2021)
The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are be
Externí odkaz:
https://doaj.org/article/718bc1047d3f4933bd7e8bad8cb30426
Autor:
Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100434- (2021)
Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of mi
Externí odkaz:
https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f