Zobrazeno 1 - 10
of 1 015
pro vyhledávání: '"L, Kirkland"'
Autor:
J. Liebmann, B. Ware, D. R. Mole, C. L. Kirkland, G. Fraser, K. Waltenberg, S. Bodorkos, D. L. Huston, N. J. Evans, B. J. McDonald, K. Rankenburg, P. Datta, S. Tessalina
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-11 (2024)
Abstract Lead isotopes are a powerful geochemical tracer and a popular tool applied across a broad range of scientific fields, e.g., earth sciences, archaeology, and forensic sciences. Here we present a Pb isotope dataset collected from 232 igneous s
Externí odkaz:
https://doaj.org/article/dd41b055b84c4ab5b7a30754d2145b00
Autor:
Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential contributo
Externí odkaz:
https://doaj.org/article/75fb6b81b5be4aa8ac501941ef1ff11d
Autor:
Rachid Safi, Suzanne E. Wardell, Paige Watkinson, Xiaodi Qin, Marissa Lee, Sunghee Park, Taylor Krebs, Emma L. Dolan, Adam Blattler, Toshiya Tsuji, Surendra Nayak, Marwa Khater, Celia Fontanillo, Madeline A. Newlin, Megan L. Kirkland, Yingtian Xie, Henry Long, Emma C. Fink, Sean W. Fanning, Scott Runyon, Myles Brown, Shuichan Xu, Kouros Owzar, John D. Norris, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis
Externí odkaz:
https://doaj.org/article/46ae3691cddb47bb9982590cd3da970d
Autor:
Christopher L. Kirkland, Maximilian Dröllner, Raphael Quentin de Gromard, Bruno V. Ribeiro, Hugo K. H. Olierook, Michael Hartnady, Milo Barham, Janne Liebmann, Hugh Smithies, Andreas Zametzer
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-12 (2024)
Abstract Deep geology of ancient continental crust can be difficult to access, with direct observation restricted to limited exposures. The age and composition of hidden geology can be gleaned from indirect isotopic modelling or via detrital minerals
Externí odkaz:
https://doaj.org/article/946e65d58a50467a966b92df434e1ddd
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Externí odkaz:
https://doaj.org/article/67f438cf2e6642df8392e5f12d364395
Autor:
Nadia Akhiyat, Ilke Ozcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L. Kirkland, Bradley Lewis, Lilach O. Lerman, Amir Lerman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Coronary microvascular dysfunction (CMD) represents an early functional characteristic of coronary vascular aging. Klotho (α‐klotho) is a circulating protein inversely linked to physiological aging. We examined low klotho as a potential
Externí odkaz:
https://doaj.org/article/5c480bf7ab324712a8b5e2e9cefc6d3a
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent gl
Externí odkaz:
https://doaj.org/article/c015455051d141358c38ab0af93970d0
Autor:
Hugo K. H. Olierook, Denis Fougerouse, Luc S. Doucet, Yebo Liu, Murray J. Rayner, Martin Danišík, Daniel J. Condon, Brent I. A. McInnes, A. Lynton Jaques, Noreen J. Evans, Bradley J. McDonald, Zheng-Xiang Li, Christopher L. Kirkland, Celia Mayers, Michael T. D. Wingate
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Argyle is the world’s largest source of natural diamonds, yet one of only a few economic deposits hosted in a Paleoproterozoic orogen. The geodynamic triggers responsible for its alkaline ultramafic volcanic host are unknown. Here we show,
Externí odkaz:
https://doaj.org/article/da6b0d81c5884c0ea196a17ad84e9747
Autor:
Yves Rolland, Felipe Sierra, Luigi Ferrucci, Nir Barzilai, Rafael De Cabo, Joan Mannick, Anthony Oliva, William Evans, Davide Angioni, Philipe De Souto Barreto, Jeremy Raffin, Bruno Vellas, James L. Kirkland, the G.C.T-TF group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to
Externí odkaz:
https://doaj.org/article/eb01587548254b758eb55498e901135e
Autor:
Alejandra Bedoya, Stijn Glorie, Martin Hand, Christopher L. Kirkland, David E. Kelsey, Angus Nixon, Geoff Fraser
Publikováno v:
Lithosphere, Vol 2023, Iss Special 14 (2024)
Combined apatite Lu–Hf, U–Pb, and fission track (AFT) triple dating affords the opportunity to investigate the ~60 and 730°C thermal history of a study area. Here, we apply apatite triple dating to resolve the tempo of multiple thermo-tectonic e
Externí odkaz:
https://doaj.org/article/11890d00a855498ca958ea8121c5ea49