Zobrazeno 1 - 10
of 312
pro vyhledávání: '"L, Kimzey A"'
Publikováno v:
Current Opinion in Toxicology
The observation of an infusion reaction (IR) in a nonclinical study can cause concern among investigators and regulators in the development of biotherapeutics. Biomarkers can be informative to determine whether the reactions are immune-mediated or te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61357db4b934014aaa3429c842f9aee
https://doi.org/10.1016/j.cotox.2017.03.005
https://doi.org/10.1016/j.cotox.2017.03.005
Publikováno v:
The Journal of Immunology. 173:632-640
Central to the pathogenesis of allergic airway inflammation are the activation and differentiation of T lymphocytes. This process requires the participation of the CD28 costimulatory receptor. Blockade of CD28 has been demonstrated to prevent inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510350e87653ebbfce13a71d7e9e2a6d
https://doi.org/10.4049/jimmunol.173.1.632
https://doi.org/10.4049/jimmunol.173.1.632
Publikováno v:
The American Journal of Pathology. 164:1727-1737
Phosphorylation of proteins on serine or threonine residues preceding proline (pSer/Thr-Pro) is a major regulatory mechanism in cell proliferation and transformation. Interestingly, the pSer/Thr-Pro motifs in proteins exist in two distinct cis and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe28d4ebf8236bcd7ee82c28c58854c
https://doi.org/10.1016/s0002-9440(10)63731-5
https://doi.org/10.1016/s0002-9440(10)63731-5
Publikováno v:
Biochemistry. 42:12691-12699
We recently demonstrated that microsomes from nicardipine-treated rats will form cytochrome P450 3A (CYP3A) aggregates when incubated at 37 degrees C. CYP3A substrates inhibited the protein aggregation and subsequent degradation, suggesting that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67fee8f964c9546a1e5388f5d96db0f
https://doi.org/10.1021/bi0349975
https://doi.org/10.1021/bi0349975
Autor:
Michael B. Blackmon, Stephanie L. Kimzey, Angela M. Preston, Jonathan M. Green, James M. Beck, Christine M. Rose
Publikováno v:
The Journal of Immunology. 171:1969-1977
Loss of T cell number and function during HIV infection or secondary to pharmacologic immunosuppression renders individuals susceptible to opportunistic infections, including Pneumocystis carinii pneumonia. Because costimulatory receptors are critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55603f606391608f3fe39b7bb9f9ff32
https://doi.org/10.4049/jimmunol.171.4.1969
https://doi.org/10.4049/jimmunol.171.4.1969
Autor:
David S. Wunschel, Janice Rice Okita, Robert J. Edwards, Amy L. Kimzey, Hyesook Kim, Richard C. Zangar, R. T. Okita
Publikováno v:
Molecular Pharmacology. 61:892-904
We characterize a novel microsome system that forms high-molecular-mass (HMM) CYP3A, CYP2E1, and ubiquitin conjugates, but does not alter CYP4A or most other microsomal proteins. The formation of the HMM bands was observed in hepatic microsomes isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67c6ead312ccd838dc9da563d8b1f96
https://doi.org/10.1124/mol.61.4.892
https://doi.org/10.1124/mol.61.4.892
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 24:563-568
Airway inflammation after inhaled allergen exposure requires the recruitment, activation, and differentiation of antigen-specific T cells into T helper (Th) 2 effector cells. These processes are regulated not only by antigen engagement of the T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1b9c706729b579ba62536ef08bfb22
https://doi.org/10.1165/ajrcmb.24.5.4375
https://doi.org/10.1165/ajrcmb.24.5.4375
Autor:
Amy L. Kimzey, A. Keith Dunker, Eric J. Ackerman, Christophe Masselon, Celeste J. Brown, Lilia M. Iakoucheva, Ethan C. Garner, Richard D. Smith, James E. Bruce
Publikováno v:
Protein Science. 10:560-571
The DNA-repair protein XPA is required to recognize a wide variety of bulky lesions during nucleotide excision repair. Independent NMR solution structures of a human XPA fragment comprising approximately 40% of the full-length protein, the minimal DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277c83d34bfbb4b4a685c2df308f0a9b
https://doi.org/10.1110/ps.29401
https://doi.org/10.1110/ps.29401
Publikováno v:
The Journal of Immunology. 164:3591-3595
T cell activation requires co-engagement of the TCR with accessory and costimulatory molecules. However, the exact mechanism of costimulatory function is unknown. Mice lacking CD2 or CD28 show only mild deficits, demonstrating that neither protein is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1eb3fffb0425d4227be7fb71eef235
https://doi.org/10.4049/jimmunol.164.7.3591
https://doi.org/10.4049/jimmunol.164.7.3591
Publikováno v:
Journal of Biological Chemistry. 274:20034-20039
Ku protein binds broken DNA ends, triggering a double-strand DNA break repair pathway. The spatial arrangement of the two Ku subunits in the initial Ku-DNA complex, when the Ku protein first approaches the broken DNA end, is not well defined. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c57c5476caa732e89b3f5e32d6148b0
https://doi.org/10.1074/jbc.274.28.20034
https://doi.org/10.1074/jbc.274.28.20034