Výsledky vyhledávání - "L, Jean Patterson"

Prototype Pathogen Approach for Vaccine and Monoclonal Antibody Development: A Critical Component of the NIAID Plan for Pandemic Preparedness

Autor: M, Cristina Cassetti, Theodore C, Pierson, L, Jean Patterson, Karin, Bok, Amanda J, DeRocco, Anne M, Deschamps, Barney S, Graham, Emily J, Erbelding, Anthony S, Fauci

Publikováno v: The Journal of Infectious Diseases.

Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) emerged 20 years ago, presaging a series of subsequent infectious disease epidemics of international concern. The recent emergence of SARS-CoV-2 has underscored the importance of targeted p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ea5abad3505fed2df034af2df47e03
https://doi.org/10.1093/infdis/jiac296

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NK and CD4+ T Cell Cooperative Immune Responses Correlate with Control of Disease in a Macaque Simian Immunodeficiency Virus Infection Model

Autor: Peng Xiao, Marjorie Robert-Guroff, Diego A. Vargas-Inchaustegui, L. Jean Patterson, Iskra Tuero

Publikováno v: The Journal of Immunology. 189:1878-1885

Control of infectious disease may be accomplished by successful vaccination or by complex immunologic and genetic factors favoring Ag-specific multicellular immune responses. Using a rhesus macaque model, we evaluated Ag-specific T cell-dependent NK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585590720a4bfdcf1b48c90b031cd273
https://doi.org/10.4049/jimmunol.1201026

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Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia

Autor: L. Jean Patterson, Peng Xiao, Rachmat Hidajat, David Venzon, Thorsten Demberg, Mara Daltabuit-Test, Egidio Brocca-Cofano, Marjorie Robert-Guroff, Katherine McKinnon

Publikováno v: Vaccine. 29:3310-3319

An effective HIV vaccine requires strong systemic and mucosal, cellular and humoral immunity. Numerous non-human primate studies have investigated memory T cells, but not memory B cells. Humoral immunologic memory is mediated by long-lived antibody-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d22d607fabc7fe0cff6e8e84a15a2b
https://doi.org/10.1016/j.vaccine.2011.02.066

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Genomic Analysis Reveals Pre- and Postchallenge Differences in a Rhesus Macaque AIDS Vaccine Trial: Insights into Mechanisms of Vaccine Efficacy

Autor: L. Jean Patterson, Robert E. Palermo, Lauri D. Aicher, Marjorie Robert-Guroff, Marcus J. Korth, Michael G. Katze

Publikováno v: Journal of Virology

We have employed global transcriptional profiling of whole blood to identify biologically relevant changes in cellular gene expression in response to alternative AIDS vaccine strategies with subsequent viral challenge in a rhesus macaque vaccine mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e97513dbc3fd11f281188bb6434342a
https://doi.org/10.1128/jvi.01522-10

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Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6PChallenge in Rhesus Macaques

Autor: Thorsten Demberg, Peng Xiao, Pamela A. Kozlowski, Rachmat Hidajat, David Venzon, L. Jean Patterson, Marjorie Robert-Guroff, Egidio Brocca-Cofano, Jun Zhao

Publikováno v: Journal of Virology. 84:7161-7173

We have shown that following priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, boosting with gp140 envelope protein enhances acute-phase protectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713e49d1d5aa79464514db271946c738
https://doi.org/10.1128/jvi.00410-10

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Replicating adenovirus vector prime/protein boost strategies for HIV vaccine development

Autor: L. Jean Patterson, Marjorie Robert-Guroff

Publikováno v: Expert Opinion on Biological Therapy. 8:1347-1363

Background: In recent years the HIV vaccine field introduced a number of promising vaccine candidates into human clinical trials. Objective: To briefly discuss the advances made in vaccine development and HIV pathogenesis and give an overview of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65b4532ccefeaaed4901ae4c05684a1
https://doi.org/10.1517/14712598.8.9.1347

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