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of 5 091
pro vyhledávání: '"L, Hoffman"'
Studies often report estimates of the average treatment effect. While the ATE summarizes the effect of a treatment on average, it does not provide any information about the effect of treatment within any individual. A treatment strategy that uses an
Externí odkaz:
http://arxiv.org/abs/2401.10867
Autor:
Emily Banks, Vincent Francis, Sheng-Jia Lin, Fares Kharfallah, Vladimir Fonov, Maxime Lévesque, Chanshuai Han, Gopinath Kulasekaran, Marius Tuznik, Armin Bayati, Reem Al-Khater, Fowzan S. Alkuraya, Loukas Argyriou, Meisam Babaei, Melanie Bahlo, Behnoosh Bakhshoodeh, Eileen Barr, Lauren Bartik, Mahmoud Bassiony, Miriam Bertrand, Dominique Braun, Rebecca Buchert, Mauro Budetta, Maxime Cadieux-Dion, Daniel G. Calame, Heidi Cope, Donna Cushing, Stephanie Efthymiou, Marwa Abd Elmaksoud, Huda G. El Said, Tawfiq Froukh, Harinder K. Gill, Joseph G. Gleeson, Laura Gogoll, Elaine S.-Y. Goh, Vykuntaraju K. Gowda, Tobias B. Haack, Mais O. Hashem, Stefan Hauser, Trevor L. Hoffman, Jacob S. Hogue, Akimoto Hosokawa, Henry Houlden, Kevin Huang, Stephanie Huynh, Ehsan G. Karimiani, Silke Kaulfuß, G. Christoph Korenke, Amy Kritzer, Hane Lee, James R. Lupski, Elysa J. Marco, Kirsty McWalter, Arakel Minassian, Berge A. Minassian, David Murphy, Juanita Neira-Fresneda, Hope Northrup, Denis M. Nyaga, Barbara Oehl-Jaschkowitz, Matthew Osmond, Richard Person, Davut Pehlivan, Cassidy Petree, Lynette G. Sadleir, Carol Saunders, Ludger Schoels, Vandana Shashi, Rebecca C. Spillmann, Varunvenkat M. Srinivasan, Paria N. Torbati, Tulay Tos, Undiagnosed Diseases Network, Maha S. Zaki, Dihong Zhou, Christiane Zweier, Jean-François Trempe, Thomas M. Durcan, Ziv Gan-Or, Massimo Avoli, Cesar Alves, Gaurav K. Varshney, Reza Maroofian, David A. Rudko, Peter S. McPherson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Developmental and epileptic encephalopathies (DEEs) feature altered brain development, developmental delay and seizures, with seizures exacerbating developmental delay. Here we identify a cohort with biallelic variants in DENND5A, encoding a
Externí odkaz:
https://doaj.org/article/67b9cc39749f4c32a8e5662c1d902770
Publikováno v:
Psychoactives, Vol 3, Iss 3, Pp 318-336 (2024)
Methamphetamine use disorder (MuD) is a global health problem, with no FDA-approved medications. Our prior work demonstrated that repeated methamphetamine exposure alters the gut microbiota in male rats and results in depressive-like behaviors. In th
Externí odkaz:
https://doaj.org/article/8f434dcca15443fe85a6c4f58dc3987c
Autor:
Shannon L. Hoffman, Paul Schmiedmayer, Aryaman S. Gala, Kevin B. Wilkins, Laura Parisi, Shreesh Karjagi, Aarushi S. Negi, Simon Revlock, Christopher Coriz, Jeremy Revlock, Vishnu Ravi, Helen Bronte-Stewart
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract People with Parkinson’s disease (PWP) face critical challenges, including lack of access to neurological care, inadequate measurement and communication of motor symptoms, and suboptimal medication management and compliance. We have develop
Externí odkaz:
https://doaj.org/article/4136cde6c1874815a3e7c5a1e43b2c1e
Autor:
Patricia Ferrer, Andrea A. Berry, Allison N. Bucsan, Surendra K. Prajapati, Karthik Krishnan, Michelle C. Barbeau, David M. Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F. Billingsley, Faith Pa’ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A. Deye, B. Kim Lee Sim, Stephen L. Hoffman, Kim C. Williamson, Kirsten E. Lyke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) N
Externí odkaz:
https://doaj.org/article/7a3ddfce59954bb4905f2bfc862aaeeb
Autor:
Devin P. Effinger, Jessica L. Hoffman, Sarah E. Mott, Sarah N. Magee, Sema G. Quadir, Christian S. Rollison, Daniel Toedt, Maria Echeveste Sanchez, Margaret W. High, Clyde W. Hodge, Melissa A. Herman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in str
Externí odkaz:
https://doaj.org/article/5c9edec683a641259bc478837e518a8c
Autor:
Anneth Tumbo, Freia-Raphaella Lorenz, Annie S.P. Yang, Stephanie Sefried, Tobias Schindler, Maximilian Mpina, Jean-Pierre Dangy, Florence A. Milando, Mohammed A. Rashid, Gloria Nyaulingo, Kamaka Ramadhani, Said Jongo, Philip L. Felgner, Yonas Abebe, B. Kim Lee Sim, L.W. Preston Church, Thomas L. Richie, Peter F. Billingsley, Tooba Murshedkar, Stephen L. Hoffman, Salim Abdulla, Peter G. Kremsner, Benjamin Mordmüller, Claudia Daubenberger, Rolf Fendel
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105364- (2024)
Summary: Background: PfSPZ Vaccine, a promising pre-erythrocytic stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from mal
Externí odkaz:
https://doaj.org/article/608a577a935848f082781131f68893d7
Autor:
Saman Abbaspoor, Kari L. Hoffman
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114519- (2024)
Summary: Diverse neuron classes in hippocampal CA1 have been identified through the heterogeneity of their cellular/molecular composition. How these classes relate to hippocampal function and the network dynamics that support cognition in primates re
Externí odkaz:
https://doaj.org/article/0574e3c632184b128cd1be60fa75b551
Autor:
Debashree Goswami, Hardik Patel, William Betz, Janna Armstrong, Nelly Camargo, Asha Patil, Sumana Chakravarty, Sean C Murphy, B Kim Lee Sim, Ashley M Vaughan, Stephen L Hoffman, Stefan HI Kappe
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 723-754 (2024)
Abstract Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, ra
Externí odkaz:
https://doaj.org/article/2fcc440695074e599b621cd9032c9199
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The study of sharp-wave ripples has advanced our understanding of memory function, and their alteration in neurological conditions such as epilepsy is considered a biomarker of dysfunction. Sharp-wave ripples exhibit diverse waveforms and pr
Externí odkaz:
https://doaj.org/article/184dadb7df3342c88f81580aeb24c8a3