Modeling the interaction between tubuloglomerular feedback and myogenic mechanisms in the control of glomerular mechanics

Autor: Owen Richfield, Ricardo Cortez, L. Gabriel Navar

Publikováno v: Frontiers in Physiology, Vol 15 (2024)

Introduction: Mechanical stresses and strains exerted on the glomerular cells have emerged as potentially influential factors in the progression of glomerular disease. Renal autoregulation, the feedback process by which the afferent arteriole changes

Externí odkaz: https://doaj.org/article/55fb0221776347528d9b30c372bb543d

Angiotensin II‐induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor‐alpha type 1 receptor

Autor: Dewan S. A. Majid, Eamonn Mahaffey, Alexander Castillo, Minolfa C. Prieto, L. Gabriel Navar

Publikováno v: Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)

Abstract In hypertension induced by angiotensin II (AngII) administration with high salt (HS) intake, intrarenal angiotensinogen (AGT) and tumor necrosis factor‐alpha (TNF‐α) levels increase. However, TNF‐α has been shown to suppress AGT form

Externí odkaz: https://doaj.org/article/06ed98b1a3104f7eb664bb34ebd5a9be

The hot button issue of salt-sensitive hypertension

Autor: Dewan S. A. Majid, L Gabriel Navar

Publikováno v: BLDE University Journal of Health Sciences, Vol 1, Iss 2, Pp 65-68 (2016)

Externí odkaz: https://doaj.org/article/4a1c95cfcb8241f5b27d79e9f3369a6e

Immunosuppression by Mycophenolate Mofetil Mitigates Intrarenal Angiotensinogen Augmentation in Angiotensin II-Dependent Hypertension

Autor: Ryousuke Satou, Martha Franco, Courtney M. Dugas, Akemi Katsurada, L. Gabriel Navar

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7680

Augmentation of intrarenal angiotensinogen (AGT) leads to further formation of intrarenal angiotensin II (Ang II) and the development of hypertensive kidney injury. Recent studies demonstrated that macrophages and the enhanced production of pro-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aac069d80a818dd3870b1d4cbca6776
https://pubmed.ncbi.nlm.nih.gov/35887028

Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure

Autor: Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 235
International Journal of Molecular Sciences, Vol 23, Iss 235, p 235 (2022)

Metabolic remodeling plays an important role in the pathophysiology of heart failure (HF). We sought to characterize metabolic remodeling and implicated signaling pathways in two rat models of early systolic dysfunction (MOD), and overt systolic HF (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fe04aecae53156f927c8c4eb56f5e
http://europepmc.org/articles/PMC8745344