Zobrazeno 1 - 10
of 173
pro vyhledávání: '"L, Charest"'
Autor:
Ashley L. Gard, Rebeccah J. Luu, Ryan Maloney, Madeline H. Cooper, Brian P. Cain, Hesham Azizgolshani, Brett C. Isenberg, Jeffrey T. Borenstein, Jane Ong, Joseph L. Charest, Else M. Vedula
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Microfluidic model of human gingival tissue with complex oral tissue architecture allows monthlong phenotypic expression, response and recovery to multiple inflammatory triggers and the potential for identification of new therapeutic targets for gum
Externí odkaz:
https://doaj.org/article/5540568cb3774a98a700f0802b6d3f31
Autor:
Rebeccah J. Luu, B. Christopher Hoefler, Ashley L. Gard, Casey R. Ritenour, Miles T. Rogers, Ernest S. Kim, Jonathan R. Coppeta, Brian P. Cain, Brett C. Isenberg, Hesham Azizgolshani, Oscar R. Fajardo-Ramirez, Guillermo García-Cardeña, Matthew P. Lech, Lindsay Tomlinson, Joseph L. Charest, Corin Williams
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Tissue fibrosis is a major healthcare burden that affects various organs in the body for which no effective treatments exist. An underlying, emerging theme across organs and tissue types at early stages of fibrosis is the activation of pe
Externí odkaz:
https://doaj.org/article/8223c1e9f8d84ea8861ab8c9956e14d2
Autor:
Samuel H. Kann, Erin M. Shaughnessey, Jonathan R. Coppeta, Hesham Azizgolshani, Brett C. Isenberg, Else M. Vedula, Xin Zhang, Joseph L. Charest
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Measurement of cell metabolism in moderate-throughput to high-throughput organ-on-chip (OOC) systems would expand the range of data collected for studying drug effects or disease in physiologically relevant tissue models. However, current me
Externí odkaz:
https://doaj.org/article/fddcf9b48a0f48a687858747142330af
Autor:
Erin M. Shaughnessey, Samuel H. Kann, Hesham Azizgolshani, Lauren D. Black, Joseph L. Charest, Else M. Vedula
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of microfluidic tissue culture platforms for drug-induced nephrotoxicity screening. Transepithelial electrical resistance (TEER) is a well-established tech
Externí odkaz:
https://doaj.org/article/3d1382b037434410ac4b50598af3fa4f
Autor:
Phanie L. Charest, Emmanuel Tessougue, Maryse Lessard, Pauline M. Herst, Pauline Navarro, Sarah Kimmins, Jacquetta M. Trasler, Amanda J. MacFarlane, Marie-Odile Benoit-Biancamano, Janice L. Bailey, Mathieu Dalvai
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Persistent organic pollutants (POPs) are ubiquitous in the environment, which is of concern since they are broadly toxic for wildlife and human health. It is generally accepted that maternal prenatal folic acid supplementation (FA) may beneficially i
Externí odkaz:
https://doaj.org/article/ac93d9bb901d408db719e6ba132b7668
Autor:
Miles T. Rogers, Ashley L. Gard, Robert Gaibler, Thomas J. Mulhern, Rivka Strelnikov, Hesham Azizgolshani, Brian P. Cain, Brett C. Isenberg, Nerses J. Haroutunian, Nicole E. Raustad, Philip M. Keegan, Matthew P. Lech, Lindsay Tomlinson, Jeffrey T. Borenstein, Joseph L. Charest, Corin Williams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Microphysiological organ-on-chip models offer the potential to improve the prediction of drug safety and efficacy through recapitulation of human physiological responses. The importance of including multiple cell types within tissue models h
Externí odkaz:
https://doaj.org/article/8cf0ffca17424706a726f4770e2e96bd
Autor:
L. Charest, Phanie
Thèse ou mémoire avec insertion d'articles.
L'omniprésence des polluants organiques persistants (POPs) dans l'environnement est due à leurs capacités à résister à la biodégradation et à se déplacer sur de grandes distances. Les POPs,
L'omniprésence des polluants organiques persistants (POPs) dans l'environnement est due à leurs capacités à résister à la biodégradation et à se déplacer sur de grandes distances. Les POPs,
Externí odkaz:
https://hdl.handle.net/20.500.11794/136524
Autor:
Benjamin O. Murray, Carlos Flores, Corin Williams, Deborah A. Flusberg, Elizabeth E. Marr, Karolina M. Kwiatkowska, Joseph L. Charest, Brett C. Isenberg, Jennifer L. Rohn
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant proportion of UTI, but a large number of other species can infect the
Externí odkaz:
https://doaj.org/article/9dc100b7beb5465f9bb36dd83b29aeb6
Publikováno v:
Tissue engineering. Part B, Reviews. 28(4)
Unraveling the complex behavior of healthy and disease podocytes by analyzing the changes in their unique arrangement of foot processes, slit diaphragm and the 3D morphology is a long-standing goal in kidney-glomerular research. The complexities surr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a88c1479e5279bb63bec434a9d94e19
https://pubmed.ncbi.nlm.nih.gov/34541902
https://pubmed.ncbi.nlm.nih.gov/34541902
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0184330 (2017)
In the kidney, the renal proximal tubule (PT) reabsorbs solutes into the peritubular capillaries through active transport. Here, we replicate this reabsorptive function in vitro by engineering a microfluidic PT. The microfluidic PT architecture compr
Externí odkaz:
https://doaj.org/article/5fa793bc386b43abbfa05872bea83fb6