Zobrazeno 1 - 10
of 522
pro vyhledávání: '"L, Carlen"'
Autor:
Xue Fan Wang, Robin Vigouroux, Michal Syonov, Yuriy Baglaenko, Angeliki M. Nikolakopoulou, Dene Ringuette, Horea Rus, Peter V. DiStefano, Suzie Dufour, Alireza P. Shabanzadeh, Seunggi Lee, Bernhard K. Mueller, Jason Charish, Hidekiyo Harada, Jason E. Fish, Joan Wither, Thomas Wälchli, Jean-François Cloutier, Berislav V. Zlokovic, Peter L. Carlen, Philippe P. Monnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver influences BCB-integrity remain elusive. One possibility is that the liver secrete
Externí odkaz:
https://doaj.org/article/863ced8c4fb94a3aaaf67d19e08288c8
Autor:
Adam C Gravitis, Krishram Sivendiran, Uilki Tufa, Katherine Zukotynski, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L Carlen, Berj L Bardakjian
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0298943 (2024)
ObjectiveApproximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so t
Externí odkaz:
https://doaj.org/article/37d73454d5c846c8808b4f6daee8df2c
Autor:
Yasaman Javadzadeh, Alexandra Santos, Mark S. Aquilino, Shanthini Mylvaganam, Karolina Urban, Peter L. Carlen
Publikováno v:
Cells, Vol 13, Iss 6, p 466 (2024)
Cannabinoids have shown potential in drug-resistant epilepsy treatment; however, we lack knowledge on which cannabinoid(s) to use, dosing, and their pharmacological targets. This study investigated (i) the anticonvulsant effect of Cannabidiol (CBD) a
Externí odkaz:
https://doaj.org/article/25e28b919c8a4bdf862adde674c16db9
Autor:
Afifa Saleem, Alexandra C. Santos, Mark S. Aquilino, Adam A. Sivitilli, Liliana Attisano, Peter L. Carlen
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e14999- (2023)
Epilepsy is a common neurological disorder that affects 1% of the global population. The neonatal period constitutes the highest incidence of seizures. Despite the continual developments in seizure modelling and anti-epileptic drug development, the m
Externí odkaz:
https://doaj.org/article/5f3ef1f74f1f4f83a5131ace82b8f1ae
Autor:
Adam C. Gravitis, Uilki Tufa, Katherine Zukotynski, David L. Streiner, Daniel Friedman, Juliana Laze, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L. Carlen, Berj L. Bardakjian
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionPrevious case-control studies of sudden unexpected death in epilepsy (SUDEP) patients failed to identify ECG features (peri-ictal heart rate, heart rate variability, corrected QT interval, postictal heart rate recovery, and cardiac rhythm
Externí odkaz:
https://doaj.org/article/8439a5ed532945ba8e20c73b8efcb8ef
Autor:
Paige Whyte-Fagundes, Daria Taskina, Nickie Safarian, Christiane Zoidl, Peter L. Carlen, Logan W. Donaldson, Georg R. Zoidl
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
The Panx1a and Panx1b (pannexin) ATP release channels exhibit pro- and anti-convulsant effects, respectively, in a zebrafish model, providing further insight into the role of pannexins in seizure development.
Externí odkaz:
https://doaj.org/article/c069c6db042d434194c16d77fdf6fa83
Autor:
Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen, Liang Zhang, Peter L. Carlen, Shreejoy J. Tripathy, Taufik A. Valiante
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/f05b2bfd5057414e93f4e1b66d51abd3
Autor:
Alexandra C. Santos, George Nader, Dana El Soufi El Sabbagh, Karolina Urban, Liliana Attisano, Peter L. Carlen
Publikováno v:
Cells, Vol 12, Iss 15, p 1949 (2023)
Human cerebral organoids resemble the 3D complexity of the human brain and have the potential to augment current drug development pipelines for neurological disease. Epilepsy is a complex neurological condition characterized by recurrent seizures. A
Externí odkaz:
https://doaj.org/article/8a6b77f9a73b4269945e568fbd3b6ba4
Autor:
Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)
Abstract Developmental and epileptic encephalopathies (DEE) are a group of disorders associated with intractable seizures, brain development, and functional abnormalities, and in some cases, premature death. Pathogenic human germline biallelic mutati
Externí odkaz:
https://doaj.org/article/87977a9dce6149adbe8551e943f5992a
Autor:
Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen, Liang Zhang, Peter L. Carlen, Shreejoy J. Tripathy, Taufik A. Valiante
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The unique biophysical properties of human cortical neurons that may underlie interlaminar communication are explored. With a focus on I h and layers 2&3, 3c, and 5, the authors show that L5 pyramidal neurons are better adapted than their superficial
Externí odkaz:
https://doaj.org/article/a8e5c0faab2d41e0b4f16f4ab7318934