Zobrazeno 1 - 10
of 78
pro vyhledávání: '"L, Bokser"'
Autor:
Oscar Levalle, L. Fiszlejder, Chervin Ab, Abraham Guitelman, L. Bokser, N.A Pacenza, G. Aszenmil
Publikováno v:
Andrologia. 16:303-309
Summary: Both gonadotropins are necessary to induce spermatogenesis in man and to recover hypophysectomized males. The patients who suffer from tumoral or traumatic hypothalamo-hypophyseal lesion use to have low endogenous gonadotropins (opposite to
Autor:
Marta Zarandi, Jozsef Zsigo, Tamás Janáky, Donald B. Olsen, Sandor Bajusz, Andrew V. Schally, L Bokser, P. Serfozo
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Analogs of the 29 amino acid sequence of growth hormone-releasing hormone (GH-RH) with agmatine (Agm) in position 29 have been synthesized by the solid phase method, purified, and tested in vitro and in vivo. The majority of the analogs contained des
Autor:
Kate Groot, Attila Juhasz, Tetsu Yano, Tamás Janáky, Attila Nagy, Jacek Pinski, Andrew V. Schally, L Bokser
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
A series of new highly potent LH-RH antagonists (T-series) has been synthesized in our laboratory. Among these analogs, antagonists [Ac-D-Nal(2), D-Phe(4Cl)2, D-Pal(3)3, D-Lys(A2pr(Car)2)6, D-Ala10]LH-RH (T-140); [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3
Publikováno v:
Biochemical and Biophysical Research Communications. 207:105-110
EGFR-T17 cells were pretreated with oleic acid and 5-10 minutes later stimulated with EGF, to study if early ionic signals are instrumental in inducing metabolic cellular response. Oleic acid blocks EGF-induced [Ca2+]i rise and Ca2+ influx without al
Publikováno v:
SEMERGEN - Medicina de Familia. 27:40-42
Autor:
Valér J. Csernus, L. Bokser, Tamás Janáky, S. Milovanovic, G. Srkalovic, Zoltan Rekasi, A. Juhász, S. Bajusz, Attila Nagy, T. W. Redding
Publikováno v:
Proceedings of the National Academy of Sciences. 89:972-976
In an attempt to produce better cytotoxic analogues, chemotherapeutic antineoplastic radicals including an alkylating nitrogen mustard derivative of D-phenylalanine (D-melphalan), reactive cyclopropane, anthraquinone derivatives [2-(hydroxymethyl)ant
Publikováno v:
Endocrinology. 127:3052-3060
Membrane receptors for LHRH were evaluated in Dunning R3327 prostate cancers and rat anterior pituitaries. The receptors were characterized both in untreated animals and after in vivo treatment with microcapsules of the agonist D-Trp6-LHRH and a sust
Autor:
Attila Juhasz, Ana Maria Comaru-Schally, Kate Groot, Gordan Srkalovic, E. Korkut, Siniša Radulović, Karoly Szepeshazi, Renzhi Cai, L Bokser, Tamás Janáky, Andrew V. Schally, Szende Bela, P. Serfozo, Tommie W. Redding
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 37:1061-1067
Many clinical approaches for the treatment of hormone-sensitive tumors are being developed based on analogs of LH-RH and somatostatin. Inhibition of the pituitary-gonadal axis forms the basis for oncological applications of LH-RH agonists like [ d -T
Publikováno v:
Scopus-Elsevier
Inhibitory effects of the potent antagonist of luteinizing hormone-releasing hormone N-Ac-[3-(2-naphthyl)-D-alanine1,4-chloro-D-phenylalanine2,3- (3-pyridyl)-D- alanine3,D-citrulline6,D-alanine10]luteinizing hormone-releasing hormone (SB-75) free of
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
The possible protective effect of an agonist of luteinising hormone-releasing hormone (LH-RH) against the ovarian damage caused by cyclophosphamide was investigated in rats. D-Trp6-LH-RH microcapsules were injected once a month for 3 months, in a dos