Zobrazeno 1 - 10
of 137
pro vyhledávání: '"L, Andreasson"'
Publikováno v:
Cell Regeneration, Vol 11, Iss 1, Pp 1-16 (2022)
Abstract Knee osteoarthritis is the most common joint disease. It causes pain and suffering for affected patients and is the source of major economic costs for healthcare systems. Despite ongoing research, there is a lack of knowledge regarding disea
Externí odkaz:
https://doaj.org/article/85466fcfca3746309d7a0adb6ea5aa37
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
RNA sequence-structure-function relationships can be studied via assays of variant activity. The authors developed a method to systematically determine ribozyme variant kinetics, using it to map double-mutant interactions and show that cleavage rate
Externí odkaz:
https://doaj.org/article/bd2de6930e9143e08b42ce2dd005876a
Publikováno v:
Heliyon, Vol 6, Iss 6, Pp e04133- (2020)
Organs and tissues, such as cartilage and limbs, are formed during development through an orchestration of growth factors that function as morphogens. Examples of growth factors include growth differentiation factor 5 (GDF5) and transforming growth f
Externí odkaz:
https://doaj.org/article/50a50a7b4d304565950c2d886c773fed
Autor:
Johan O L, Andreasson, Michael R, Gotrik, Michelle J, Wu, Hannah K, Wayment-Steele, Wipapat, Kladwang, Fernando, Portela, Roger, Wellington-Oguri, Rhiju, Das, William J, Greenleaf
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Internet-based scientific communities promise a means to apply distributed, diverse human intelligence toward previously intractable scientific problems. However, current implementations have not allowed communities to propose experiments to test all
Akademický článek
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Publikováno v:
ACS Synthetic Biology
Riboswitches that couple binding of ligands to conformational changes offer sensors and control elements for RNA synthetic biology and medical biotechnology. However, design of these riboswitches has required expert intuition or software specialized
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4626c73fc88e13b4f6bbfc5a0585352
https://escholarship.org/uc/item/7tz0p2xn
https://escholarship.org/uc/item/7tz0p2xn
Autor:
Michelle J Wu, Johan O. L. Andreasson, Evan A. Boyle, William J. Greenleaf, Samuel H. Sternberg, Jennifer A. Doudna, Chantal K. Guegler, Lauren M. Chircus
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 21
The bacterial adaptive immune system CRISPR-Cas9 has been appropriated as a versatile tool for editing genomes, controlling gene expression, and visualizing genetic loci. To analyze Cas9's ability to bind DNA rapidly and specifically, we generated mu
Riboswitches that couple binding of ligands to recruitment of molecular machines offer sensors and control elements for RNA synthetic biology and medical biotechnology. Current approaches to riboswitch design enable significant changes in output acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76aae92d8ca27b887c1cdf0691cc9cb
Publikováno v:
Biophysical Journal. 120:286a