Zobrazeno 1 - 10
of 216
pro vyhledávání: '"L'Houcine Ouafik"'
Autor:
Philippe Metellus, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors. The treatment of patients with TRK fusion cancer with a first-generation TRK inhibitor (such as laro
Externí odkaz:
https://doaj.org/article/ed3fc3c4abd840519e77be3825438190
Autor:
Carine Jiguet-Jiglaire, Sebastien Boissonneau, Emilie Denicolai, Victoria Hein, Romain Lasseur, Josep Garcia, Sylvie Romain, Romain Appay, Thomas Graillon, Warren Mason, Antoine F. Carpentier, Alba A. Brandes, L.’Houcine Ouafik, Wolfgang Wick, Ania Baaziz, Julien P. Gigan, Rafael J. Argüello, Dominique Figarella-Branger, Olivier Chinot, Emeline Tabouret
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract We previously identified matrix metalloproteinase 2 (MMP2) and MMP9 plasma levels as candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. The aim of this study was to assess the predictive value of MMP2 and M
Externí odkaz:
https://doaj.org/article/699a6ad92f1a400fa0b9d1249588ad83
Autor:
Eric Pellegrino, Coralie Jacques, Nathalie Beaufils, Isabelle Nanni, Antoine Carlioz, Philippe Metellus, L’Houcine Ouafik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Since 2017, we have used IonTorrent NGS platform in our hospital to diagnose and treat cancer. Analyzing variants at each run requires considerable time, and we are still struggling with some variants that appear correct on the metrics at fi
Externí odkaz:
https://doaj.org/article/f2cc208aa9504b5da4bddc6b83fc1c28
Autor:
Eric Pellegrino, Clara Camilla, Norman Abbou, Nathalie Beaufils, Christel Pissier, Jean Gabert, Isabelle Nanni-Metellus, L’Houcine Ouafik
Publikováno v:
Bioengineering, Vol 10, Iss 7, p 753 (2023)
The advent of next-generation sequencing (NGS) technologies has revolutionized the field of bioinformatics and genomics, particularly in the area of onco-somatic genetics. NGS has provided a wealth of information about the genetic changes that underl
Externí odkaz:
https://doaj.org/article/1a0d166be1784b5a9a0992983e8fc0db
Autor:
Diane Frankel, Isabelle Nanni, L’Houcine Ouafik, Laurent Greillier, Hervé Dutau, Philippe Astoul, Laurent Daniel, Elise Kaspi, Patrice Roll
Publikováno v:
Cells, Vol 12, Iss 5, p 754 (2023)
Background: Lung cancer has become the leading cause of cancer death for men and women. Most patients are diagnosed at an advanced stage when surgery is no longer a therapeutic option. At this stage, cytological samples are often the less invasive so
Externí odkaz:
https://doaj.org/article/b4d19af006d24ea7947e667f412116ad
Autor:
Norman Abbou, Pauline Piazzola, Jean Gabert, Vincent Ernest, Robin Arcani, Anne-Laure Couderc, Antoine Tichadou, Pauline Roche, Laure Farnault, Julien Colle, L’houcine Ouafik, Pierre Morange, Régis Costello, Geoffroy Venton
Publikováno v:
Cells, Vol 12, Iss 1, p 105 (2022)
BCR::ABL1-negative myeloproliferative neoplasms (MPNs) include three major subgroups—polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)—which are characterized by aberrant hematopoietic proliferation with an i
Externí odkaz:
https://doaj.org/article/b7239ef8ab9b40f2bde93e624c1b2d29
Autor:
Romain Sigaud, Nadège Dussault, Caroline Berenguer-Daizé, Christine Vellutini, Zohra Benyahia, Mylène Cayol, Fabrice Parat, Kamel Mabrouk, Ramiro Vázquez, Maria E. Riveiro, Philippe Metellus, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
VE-cadherin is an essential adhesion molecule in endothelial adherens junctions, and the integrity of these complexes is thought to be regulated by VE-cadherin tyrosine phosphorylation. We have previously shown that adrenomedullin (AM) blockade corre
Externí odkaz:
https://doaj.org/article/213926a4514e458da5ff6110a8a97da0
Autor:
Melanie Donnette, Loic Osanno, Madeleine Giocanti, Geoffroy Venton, Laure Farnault, Yael Berda-Haddad, Régis Costello, Solas Caroline, L.’Houcine Ouafik, Joseph Ciccolini, Raphaëlle Fanciullino
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:231-238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef574f3dfe8ab7aaa70cdc6a1b1f507
https://doi.org/10.1007/s00280-023-04505-y
https://doi.org/10.1007/s00280-023-04505-y
Autor:
Ramiro Vázquez, Maria E. Riveiro, Caroline Berenguer-Daizé, Anthony O’Kane, Julie Gormley, Olivier Touzelet, Keyvan Rezai, Mohamed Bekradda, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
The development, maintenance and metastasis of solid tumors are highly dependent on the formation of blood and lymphatic vessels from pre-existing ones through a series of processes that are respectively known as angiogenesis and lymphangiogenesis. B
Externí odkaz:
https://doaj.org/article/0b84dc59b8ec4ae59443acb33c753ec2
Autor:
Anne-Marie Ruppert, MD, PhD, Michèle Beau-Faller, MD, PhD, Didier Debieuvre, MD, L’Houcine Ouafik, MD, PhD, Virginie Westeel, MD PhD, Isabelle Rouquette, MD, Julien Mazières, MD, PhD, Pierre-Paul Bringuier, MD, Isabelle Monnet, MD, Fabienne Escande, MD, Charles Ricordel, MD, Jean-Philippe Merlio, MD, PDh, Henri Janicot, MD, Antoinette Lemoine, MD, PhD, Pascal Foucher, MD, Michel Poudenx, MD, Franck Morin, MSc, Alexandra Langlais, MSc, Pierre-Jean Souquet, MD, PhD, Fabrice Barlesi, MD, PhD, Marie Wislez, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 1, Iss 3, Pp 100052- (2020)
Introduction: KRAS mutations are detected in 20% to 30% of NSCLC. However, KRAS mutation subtypes may differently influence the outcome of patients with advanced NSCLC. Methods: In the Biomarkers France study, 4894 KRAS mutations (26.2%) were detecte
Externí odkaz:
https://doaj.org/article/0738da11c0534bb49bbf4eba273784d4