Mutations linked to neurological disease enhance self-association of low-complexity protein sequences

Autor: Xiaoming Zhou, Lily Sumrow, Kyuto Tashiro, Lillian Sutherland, Daifei Liu, Tian Qin, Masato Kato, Glen Liszczak, Steven L. McKnight

Publikováno v: Science

Protein domains of low sequence complexity do not fold into stable, three-dimensional structures. Nevertheless, proteins with these sequences assist in many aspects of cell organization, including assembly of nuclear and cytoplasmic structures not su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8afce5ac3de7d9dcb55e1df651f38ed
https://doi.org/10.1126/science.abn5582

A protein semisynthesis-based strategy to probe the impact of site-specific serine ADP-ribosylation on linker histone function

Autor: Kyuto Tashiro, Jugal Mohapatra, Chad A. Brautigam, Glen Liszczak

Recently developed chemical and enzyme-based technologies to install serine ADP-ribosylation onto synthetic peptides have enabled new approaches to study PARP biology. Here, we establish a generalizable strategy to prepare ADP-ribosylated peptides th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::130e611e6e313bb9523b327d7a33b5fa
https://doi.org/10.1101/2022.02.17.480967

Author response: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

Autor: Jugal Mohapatra, Kyuto Tashiro, Ryan L Beckner, Jorge Sierra, Jessica A Kilgore, Noelle S Williams, Glen Liszczak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1b3ba5c48fe0c71af14c4d6f1155ce8
https://doi.org/10.7554/elife.71502.sa2

Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria

Autor: David McKenney, Louis E. Metzger, Dirksen E. Bussiere, Sylvia Ma, Ashish Patel, Bhavesh Dhumale, Upendra Kulkarni, Jay Parthiban Lakshman, Sean King, Duncan Armstrong, Kyuto Tashiro, Lauren Kossy, Tushar Patel, Lauren M. Holder, Jogitha Selvarajah, Sarah Williams, Satya Yendluri, Colin Osborne, Jason Vo, Mangesh Fulsunder, Xiaolan Ling, Laura Wedel, Gianfranco De Pascale, Jennifer A. Leeds, Cody Cepura, Heinz E. Moser, Alexey Rivkin, Sunil Namballa, Colin K. Skepper, Bhavin Kantariya, Mina Mostafavi, Bhautik Savani, Anatoli Lvov, Guillaume Lapointe, Cornelia Bellamacina, Bhavesh Vora, Daryl L. Richie, Helen Chan, Wosenu Mergo, Jianwei Bian, Wei Shu, Keshav Mhaske, Aregahegn Yifru, Mark R. Sanderson, Swapnil Malekar, Johanne Blais, Qin Yue, Yong Zhang, Katherine V. Thompson, Julie Kim, Charles R. Dean, Vijay Sethuraman, Trixie Wagner, L. Mark Fisher, Dennis A. Veselkov, Darshit Patel, Folkert Reck, Jonas Noeske, Krishniah Vaarla, Lakhan Vala, Shailesh Satasia, Krunal Prajapati, Philippe Piechon, Valery Polyakov, Katherine R Prosen

Publikováno v: Lapointe, G, Skepper, C K, Holder, L M, Armstrong, D, Bellamacina, C, Blais, J, Bussiere, D, Bian, J, Cepura, C, Chan, H, Dean, C R, De Pascale, G, Dhumale, B, Fisher, L M, Fulsunder, M, Kantariya, B, Kim, J, King, S, Kossy, L, Kulkarni, U, Lakshman, J, Leeds, J A, Ling, X, Lvov, A, Ma, S, Malekar, S, McKenney, D, Mergo, W, Metzger, L, Mhaske, K, Moser, H E, Mostafavi, M, Namballa, S, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Piechon, P, Polyakov, V, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Sanderson, M R, Satasia, S, Savani, B, Selvarajah, J, Sethuraman, V, Shu, W, Tashiro, K, Thompson, K V, Vaarla, K, Vala, L, Veselkov, D A, Vo, J, Vora, B, Wagner, T, Wedel, L, Williams, S L, Yendluri, S, Yue, Q, Yifru, A, Zhang, Y & Rivkin, A 2021, ' Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria ', Journal of Medicinal Chemistry, vol. 64, no. 9, pp. 6329-6357 . https://doi.org/10.1021/acs.jmedchem.1c00375

Herein, we describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV via binding to, and stabilization of, DNA cleavage complexes. Optimization of this series led to the identification of compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56db96726415696056387173baa99222
https://kclpure.kcl.ac.uk/en/publications/675d57ab-71d9-4244-886c-019cc57306cd

IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor

Autor: Sandro Nocito, Anthony Casarez, Sara Lopez, Cindy Li, Louis E. Metzger, Johanne Blais, Kyuto Tashiro, Charles R. Dean, Kaci Phizackerley, Alun Bermingham, Dazhi Tang, Folkert Reck, Jacob Shaul, Richard Colvin, Markus Furegati, Dita M. Rasper, Robert Lowell Simmons, Luis Gamboa, Qin Yue, Xiaoyu Shen, Ellena Growcott, Flavio Ossola

Publikováno v: ACS infectious diseases. 5(7)

Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the expression of β-lactamases, and co-dosing of β-lactams with a β-lactamase inhibitor (BLI) is a clinically proven strategy to address resistance. New β-lactamases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e24fac6712fce3273dfecedd99e4d18
https://pubmed.ncbi.nlm.nih.gov/30861342