Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kyunghye Ahn"'
Autor:
Andrea Arendse, Tracy Stevenson, Tyzoon K. Nomanbhoy, Marya Liimatta, Jessica P. Alexander, Douglas S. Johnson, Laura R Fitzgerald, Kyunghye Ahn, Richard A. Nugent, Benjamin F. Cravatt, Eric T Lund
Publikováno v:
Biochemistry. 46:13019-13030
Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic, anti-inflamm
Autor:
Benjamin F. Cravatt, Kyunghye Ahn, Billy R. Martin, S. A. Varvel, Pattipati S. Naidu, Aron H. Lichtman
Publikováno v:
Psychopharmacology. 192:61-70
Manipulations of the endocannabinoid/fatty acid amide hydrolase (FAAH) signaling systems result in conflicting and paradoxical effects in rodent models of emotional reactivity.In the present study, we tested the hypothesis that the inhibition of FAAH
Publikováno v:
Journal of Biological Chemistry. 278:49691-49698
Oxygen activation occurs at a wide variety of enzyme active sites. Mechanisms previously proposed for the copper monooxygenase, dopamine beta-monooxygenase (DbetaM), involve the accumulation of an activated oxygen intermediate with the properties of
Publikováno v:
Journal of Cardiovascular Pharmacology. 36:S22-S25
Phosphoramidon has been shown to inhibit endothelin-converting enzyme-1 (ECE-1) in a remarkably pH-dependent manner (Ahn et al. Arch Biochem Biophys 1998;359:258-68). In order to determine whether this dramatic pH-dependence is a general phenomenon o
Publikováno v:
Archives of Biochemistry and Biophysics. 373:385-393
Endothelin converting enzyme-1 (ECE-1) is a type II integral membrane protein and a zinc metalloendopeptidase. ECE-1 generates endothelin-1 (ET-1), the most potent vasoconstrictor yet discovered, by specific proteolytic processing of a precursor pept
Publikováno v:
Journal of Biological Chemistry. 274:4053-4058
Endothelins are peptide hormones with a potent vasoconstrictor activity that are also known to function as intercellular signaling molecules. The final step in the biosynthesis of endothelins is the proteolytic processing of precursor peptides by end
Autor:
Kyunghye Ahn, Semiko Kaw, Richard L Schroeder, Sharon Pan, Sarah B. Herman, Masashi Yanagisawa, Stephen J. Haleen, Donald Hupe, Noriaki Emoto, Sham S. Nikam, Xue Min Cheng, Andre M. Sisneros, Lee Chitase, Annette M. Doherty
Publikováno v:
Biochemical and Biophysical Research Communications. 243:184-190
PD 069185 is a highly selective and structurally novel inhibitor of endothelin converting enzyme-1 (ECE-1). PD 069185 is a trisubstituted quinazoline with an IC50 value of 0.9 +/- 0.1 microns for inhibition of human ECE-1 from the solubilized membran
Autor:
Kyunghye Ahn, Sarah B. Herman, William C. Patt, Annette Marian Doherty, Andre M. Sisneros, Mark A. Massa
Publikováno v:
ChemInform. 30
Autor:
Kyunghye Ahn, Johnson Gary D
Publisher Summary This chapter focuses on the structural chemistry of Endothelin-Converting Enzyme 1 (ECE-1). The ECE-1 is a type II integral membrane protein with a short N-terminal cytoplasmic tail, a transmembrane hydrophobic domain and a large ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28ed0a852e3938e421eebd068c0f97c
https://doi.org/10.1016/b978-0-12-079611-3.50118-x
https://doi.org/10.1016/b978-0-12-079611-3.50118-x
Publikováno v:
The Journal of biological chemistry. 278(50)
Oxygen activation occurs at a wide variety of enzyme active sites. Mechanisms previously proposed for the copper monooxygenase, dopamine beta-monooxygenase (DbetaM), involve the accumulation of an activated oxygen intermediate with the properties of