Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kyunghee Yang"'
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4
Autor:
James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9692 (2023)
Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total
Externí odkaz:
https://doaj.org/article/cf333ce0b61346e283a0479af7d19b6d
Autor:
William A. Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J. Beaudoin, Jessica Spires, Scott Q. Siler, Sibylle Neuhoff, Kim L.R. Brouwer
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:275-297
Nonalcoholic fatty liver disease (NAFLD), representing a clinical spectrum ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), is rapidly evolving into a global pandemic. Patients with NAFLD are burdened with high rat
Autor:
Yeshitila Gebremichael, Evren Atillasoy, Brett A. Howell, F. Jay Murray, Kyunghee Yang, Hartmut Jaeschke, Edwin Kuffner, John C.K. Lai, Gary Eichenbaum, Cathy K. Gelotte, Daniele Wikoff, David Jacobson-Kram
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 118
In 2019, the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. The objective of the analysis herein was to inform this review by assessing whether variability
Autor:
Edwin Kuffner, Samuel M. Cohen, Milind Deore, Andrew D. Monnot, Evren Atillasoy, Gary Eichenbaum, Cathy K. Gelotte, Anne Hermanowski-Vosatka, Suren B. Bandara, Michael Kovochich, Jerry F. Hardisty, Brett A. Howell, Suresh Kumar Pitchaiyan, F. Jay Murray, Kyunghee Yang, John C.K. Lai, Yeshitila Gebremichael, Kenneth M. Unice, David Jacobson-Kram
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 118
In 2019 the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen, including an assessment of the long-term rodent carcinogenicity and tumor initiation/promotion s
Autor:
Simone H. Stahl, Christina Battista, Paul B. Watkins, Scott Q. Siler, Jerome T. Mettetal, Kyunghee Yang, Brett A. Howell
Publikováno v:
Toxicological Sciences
CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicolog
Autor:
Scott Q. Siler, Simone H. Stahl, Jeffrey L. Woodhead, Brett A. Howell, Christina Battista, Kyunghee Yang, Jerome T. Mettetal, Paul B. Watkins
Publikováno v:
Clinical Pharmacology and Therapeutics
Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific enzymes/transporters.
Autor:
Kim L. R. Brouwer, Robert L. St. Claire, Jeffrey L. Woodhead, Paul B. Watkins, Cen Guo, Scott Q. Siler, Kyunghee Yang, Brett A. Howell
Publikováno v:
Journal of Pharmaceutical Sciences. 105:443-459
Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile networks. Therefore, this cellular model is a unique tool that can be used to estimate bilia
Autor:
Joseph W. Polli, Jonathan Maher, Kunal S Taskar, A. David Rodrigues, Christoph Funk, Michael J. Hafey, Robert W. Yucha, Kim L. R. Brouwer, Y. Anne Pak, Paul B. Watkins, David Dai, Jenny M. Pedersen, David L. Bourdet, Kyunghee Yang, Christina Battista, J. Gerry Kenna, Yurong Lai, Kenneth R. Brouwer
Publikováno v:
Clinical Pharmacology and Therapeutics
Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may contribute to the initiation of human drug-induced liver injury (DILI). Proactive evaluation and understanding of BSEP inhibition is recommended in drug discovery
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:415-423
The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CLBile) versus basolateral effl