Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyunghee X Kim"'
Autor:
Kyunghee X Kim, Joel D Sanneman, Hyoung-Mi Kim, Donald G Harbidge, Jie Xu, Manoocher Soleimani, Philine Wangemann, Daniel C Marcus
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97191 (2014)
Several members of the SLC26 gene family have highly-restricted expression patterns in the auditory and vestibular periphery and mutations in mice of at least two of these (SLC26A4 and SLC26A5) lead to deficits in hearing and/or balance. A previous r
Externí odkaz:
https://doaj.org/article/a4af9d3081b24515b3e3cae7919f4d65
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors compare receptive fields and nonlinearities of synaptic inputs, membrane potentials, and spiking activity in the auditory cortex for broadband stimuli revealing distinct differences, which lead to an increase in feature selectivity from n
Externí odkaz:
https://doaj.org/article/9d4f940ff86e46ef8801ea5c7f37b9c1
Autor:
Kyunghee X. Kim, Corby L. Dale, Kamalini G. Ranasinghe, Hardik Kothare, Alexander J. Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S. Nagarajan, John F. Houde
Background: Alzheimer’s disease (AD) is a neurodegenerative disease involving cognitive impairment and abnormalities in speech and language. Here, we examine how AD affects the fidelity of auditory feedback predictions during speaking. We focus on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f495cfcf2949229aecd55d0985bc41ff
https://doi.org/10.21203/rs.3.rs-2248797/v1
https://doi.org/10.21203/rs.3.rs-2248797/v1
Autor:
Kyunghee X. Kim, Corby L. Dale, Kamalini G. Ranasinghe, Hardik Kothare, Alexander J. Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S. Nagarajan, John F. Houde
Publikováno v:
eneuro. :ENEURO.0056-23.2023
Alzheimer’s disease (AD) is a neurodegenerative disease involving cognitive impairment and abnormalities in speech and language. Here, we examine how AD affects the fidelity of auditory feedback predictions during speaking. We focus on the phenomen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a898926e6cc7635b893624ba0ea26c35
https://doi.org/10.1523/eneuro.0056-23.2023
https://doi.org/10.1523/eneuro.0056-23.2023
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b792d17da7c94cb0b03747db266075
http://link.springer.com/article/10.1038/s41467-020-14835-7
http://link.springer.com/article/10.1038/s41467-020-14835-7
Publikováno v:
The Journal of General Physiology
Proteins other than TMC1 and TMC2 must contribute to the pore of the mechanotransducer channel of cochlear hair cells; an external vestibule subject to disruption in Tmc mutants may influence the channel’s properties.
Transmembrane channel–l
Transmembrane channel–l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eba67cda0f13fc0811921c2fa2fef86
http://europepmc.org/articles/PMC4076520
http://europepmc.org/articles/PMC4076520
Autor:
Maryline Beurg, David N. Furness, Carole M. Hackney, Robert Fettiplace, Shanthini Mahendrasingam, Kyunghee X. Kim
Publikováno v:
The Journal of General Physiology
Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear hair cells, putting tension on the tip links connecting the stereocilia and thereby opening mechanotransducer (MT) channels. Tmc1 and Tmc2, two members of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8badff4b588e32b10c202e7b4ef7b58
https://doi.org/10.1085/jgp.201311068
https://doi.org/10.1085/jgp.201311068
Autor:
Robert Fettiplace, Kyunghee X. Kim
Publikováno v:
The Journal of General Physiology
Vibration of the stereociliary bundles activates calcium-permeable mechanotransducer (MT) channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea respond preferentially to different acoustic frequencies, with var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f23f56a207b20ac45a7dafb89b42d6
https://doi.org/10.1085/jgp.201210913
https://doi.org/10.1085/jgp.201210913
Autor:
Yorgo Modis, Adel M. Nour, Jin Wook Park, Bing Ma, Chang-Min Lee, Chun Geun Lee, Mahmoud L. Nasr, Jack A. Elias, Charles S. Dela Cruz, Chuan Hua He, Yang Zhou, Lokesh Sharma, Kyunghee X. Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications
Nature Communications
Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2. However, the mechanism that IL-13Rα2 uses to mediate the effects of Chi3l1 has not been defined. Here, we demonstrate that the membrane protein, TMEM219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091ac784c60aa7d7ae5eb7a151dcd17f
https://www.repository.cam.ac.uk/handle/1810/266405
https://www.repository.cam.ac.uk/handle/1810/266405
Autor:
Kyunghee X. Kim, Mark A. Rutherford
Auditory nerve excitation and thus hearing depend on spike-generating ion channels and their placement along the axons of auditory nerve fibers (ANFs). The developmental expression patterns and native axonal locations of voltage-gated ion channels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5080b20c25fcbfeeed2d61df592bd62
https://europepmc.org/articles/PMC6602042/
https://europepmc.org/articles/PMC6602042/