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pro vyhledávání: '"Kyungha Chung"'
Autor:
Aeri Kim, Kyungha Chung, Kim Tae-Hun, Sun-Hwa Lee, Sung-Hack Lee, Suk-Kyoon Yoon, Hee Dong Park, Jihye Lee, Seungyup Paek, Bongchan Kim, Eunice EunKyeong Kim
Publikováno v:
Molecular Pharmaceutics. 13:1197-1205
LB30870, a new direct thrombin inhibitor, showed 80% reduction in oral bioavailability in fed state. The present study aims to propose trypsin binding as a mechanism for such negative food effect and demonstrate a prodrug approach to mitigate food ef