Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kyungah Maeng"'
Autor:
Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We previously showed that elevated TS exhibits properties of an oncogene and promotes pancreati
Externí odkaz:
https://doaj.org/article/c4d8ea92daf8429f8458305e8f8361ea
Autor:
Frederic J. Kaye, William W. Hauswirth, Maria Zajac-Kaye, Sanford L. Boye, Arun Srivastava, Rony A. Francois, Mary K. Reinhard, Min Chen, Akbar Nawab, Kyungah Maeng, George Aslanidi, Julie K. Bray
Publikováno v:
Human Gene Therapy Methods. 28:49-59
Despite efforts to use adeno-associated viral (AAV) vector–mediated gene therapy for treatment of pancreatic ductal adenocarcinoma (PDAC), transduction efficiency remains a limiting factor and thus improvement of AAV delivery would significantly fa
Autor:
Kyungah Maeng, Gyeoung Jin Kang, Josef T. Prchal, Hung-The Dang, Donghoon Yoon, Hee-Kyoung Kang, Hye-Ja Lee, Jee H. Jung, Eun-Sook Yoo, Chongsuk Ryou
Publikováno v:
Journal of Molecular Medicine. 89:83-90
Inflammation as a major defense mechanism against pathogens is modulated by diverse microbial products. A variety of plant and microbial products interacting with Toll-like receptors initiate a wide spectrum of responses from phagocytosis to cytokine
Autor:
Henia Dar, Daniel Henderson, Zinkal Padalia, Ashley Porras, Dakai Mu, Kyungah Maeng, Seshi Police, Demetrios Kalaitzidis, Jonathan Terrett, Jason Sagert
Publikováno v:
Cancer Research. 78:1540-1540
B cell maturation antigen (BCMA) is a tumor necrosis factor family cell surface receptor that binds B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) and is involved in the long-term survival of B cells. BCMA has been shown
Autor:
Soyeon Ahn, Jihun Kim, Steven N. Hochwald, Min Chen, Frederic J. Kaye, Kyungah Maeng, Woo Ho Kim, Carmen J. Allegra, Maria Zajac-Kaye, Hye Seung Lee
Publikováno v:
International journal of cancer. 135(1)
Thymidylate synthase (TS), a critical enzyme for DNA synthesis and repair, is both a potential tumor prognostic biomarker as well as a tumorigenic oncogene in animal models. We have now studied the clinical implications of TS expression in gastroente
Publikováno v:
Cancer letters. 300(2)
The present study was performed to investigate the possible combined use of the Cox-2 inhibitor niflumic acid and the PPARγ ligand ciglitazone and to elucidate the mechanisms underlying enhanced apoptosis by this combination treatment in human lung
Publikováno v:
International journal of oncology. 34(5)
Several lines of evidence suggest that non-steroidal anti-inflammatory drugs (NSAIDs) have a radiosensitizing effect on cancer cells in vitro and in vivo, but little is known about the underlying cellular mechanism. In this study, we found that the t
Autor:
Maria Zajac-Kaye, Akbar Nawab, Kyungah Maeng, Steven N. Hochwald, Rony A. Francois, Frederic J. Kaye
Publikováno v:
Journal of the National Cancer Institute. 107:djv123
Background Focal adhesion kinase (FAK) mediates survival of normal pancreatic islets through activation of AKT. Upon malignant transformation of islet cells into pancreatic neuroendocrine tumors (PanNETs), AKT is frequently overexpressed and mutation
Publikováno v:
Cancer Research. 74:3922-3922
The incidence of pancreatic neuroendocrine tumors (PNET) is rapidly increasing and the prevalence in the US is now estimated to be over 100,000. The lack of a suitable animal model that recapitulates the human disease has limited development of new t
Publikováno v:
Cancer Research. 73:631-631
Thymidylate synthase (TS) is a well-established chemotherapy target frequently overexpressed in cancer. Multiple clinical studies demonstrated that high levels of TS correlate with the disease stage and resistance to fluoropyrimidine chemotherapy. Pr