Zobrazeno 1 - 10
of 576
pro vyhledávání: '"Kyung-Sang Yu"'
Autor:
Seolah Lee, Hyun Chul Kim, Yoonhyuk Jang, Han Sang Lee, Seon‐Jae Ahn, Soon‐Tae Lee, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Jaeseong Oh, SeungHwan Lee, Kyung‐Sang Yu, In‐Jin Jang, Soyoung Lee, Kon Chu, Sang Kun Lee
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 424-435 (2024)
Abstract Objective Despite the suggested topiramate serum level of 5–20 mg/L, numerous institutions have observed substantial drug response at lower levels. We aim to investigate the correlation between topiramate serum levels, drug responsiveness,
Externí odkaz:
https://doaj.org/article/d89b2860b4d64fadb1f2e7063f686429
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract Pioglitazone is class of thiazolidinediones that activates peroxisome proliferator‐activated receptors (PPARs) in adipocytes to improve glucose metabolism and insulin sensitivity and has been used as a treatment for type 2 diabetes. Howeve
Externí odkaz:
https://doaj.org/article/38ef3bb3f3d84a22a017c1b2d027fe71
Autor:
Ki Young Huh, Woo Kyung Chung, Jiyeon Park, SeungHwan Lee, Min‐Gul Kim, Jaeseong Oh, Kyung‐Sang Yu
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2177-2188 (2023)
Abstract Decentralized clinical trials (DCTs) leverage digital technologies to reduce dependency on study sites and intermediaries. DCT should be balanced with accessibility and data reliability while meeting regulatory requirements. Here, we conduct
Externí odkaz:
https://doaj.org/article/bb12b2c524c84c39bbedd1774c272e90
Autor:
Heejae Won, Deok Yong Yoon, Sangmi Lee, Joo‐Youn Cho, Jaeseong Oh, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Vutiglabridin, which affects the pharmacokinetics (PKs) of food, is currently under clinical development for the treatment of obesity. This study aimed to evaluate the effects of low‐ and high‐fat meals on PKs of vutiglabridin in healthy
Externí odkaz:
https://doaj.org/article/264b145fc6ce4606b5e8e24ef5de711e
Autor:
Ki Young Huh, Sejung Hwang, Joo Young Na, Kyung‐Sang Yu, In‐Jin Jang, Jae‐Yong Chung, Seonghae Yoon
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Genetic variants affect drug responses, making pre‐emptive genotyping crucial for averting serious adverse events (SAEs) and treatment failure. However, assessing the benefits of pre‐emptive genotyping based on genetic distribution, drug
Externí odkaz:
https://doaj.org/article/be49a045dd3c44f4b4e8fff1328ad795
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1866-1875 (2023)
Abstract Treatment adherence is an underestimated determinant of treatment success. Poor treatment adherence can also affect the efficacy of clinical trials. A combination of multiple adherence‐monitoring methods is required to ensure robustness. W
Externí odkaz:
https://doaj.org/article/acca93d8d23c4566bc877854a7b50c1a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1319-1334 (2023)
Abstract Tripegfilgrastim is a long‐acting granulocyte colony‐stimulating factor (G‐CSF) that has been used to prevent chemotherapy‐induced neutropenia in adults. This study aimed to establish a pharmacokinetic (PK)–pharmacodynamic (PD) mod
Externí odkaz:
https://doaj.org/article/68a8aaaf5b0a4c0ab208b20b6907eb07
Autor:
Sunhee An, Jieun Ko, Kyung-Sang Yu, Hyuktae Kwon, Sungwan Kim, Jeeyoung Hong, Hyoun-Joong Kong
Publikováno v:
Healthcare Informatics Research, Vol 29, Iss 3, Pp 190-198 (2023)
Objectives As the Fourth Industrial Revolution advances, there is a growing interest in digital technology. In particular, the use of digital therapeutics (DTx) in healthcare is anticipated to reduce medical expenses. However, analytical research on
Externí odkaz:
https://doaj.org/article/5565719f052e4d45be8f2c33017789d6
Autor:
Min Young Park, Sungyeun Bae, Jung A Heo, Mihee Park, YuKyung Kim, Jumi Han, In‐Jin Jang, Kyung‐Sang Yu, Jaeseong Oh
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1163-1176 (2023)
Abstract Bersiporocin, a novel first‐in‐class prolyl‐tRNA synthetase (PRS) inhibitor currently under clinical development, was shown to exert an antifibrotic effect through the downregulation of collagen synthesis in various pulmonary fibrosis
Externí odkaz:
https://doaj.org/article/d80f7f55c88e4d17ade79b7552a0db14
Autor:
Bo Rim Kim, Leerang Lim, YoungRok Choi, Nam‐Joon Yi, Kwang‐Woong Lee, Kyung‐Suk Suh, Kyung‐Sang Yu, Jin Young Sohn, Raewon Jeong, Jaeseong Oh, Ho Geol Ryu
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1177-1185 (2023)
Abstract Antithrombin‐III (AT‐III) concentrates have been used in the immediate postoperative period after liver transplantation to prevent critical thrombosis. We aimed to investigate a more appropriate method for AT‐III concentrate administra
Externí odkaz:
https://doaj.org/article/54a83e171ae6436cbc579c06321388d1