Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyung-Pil Ko"'
Autor:
Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114286- (2024)
Summary: Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plastic
Externí odkaz:
https://doaj.org/article/7beabc5633f54eef9bcd464bc524689b
Autor:
Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Yahui Zhao, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Haiyang Zhang, Zhihua Liu, Jae-Il Park
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109795- (2024)
Summary: Despite the promising outcomes of immune checkpoint inhibitors (ICIs), resistance to ICI presents a new challenge. Therefore, selecting patients for specific ICI applications is crucial for maximizing therapeutic efficacy. Herein, we curated
Externí odkaz:
https://doaj.org/article/b0c57a6133c14aa2a1408bad70cd2bfc
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101317- (2022)
Summary: Organoid systems are commonly used for disease modeling because of their faithful recapitulation of tissue homeostasis, tissue regeneration, and disease processes. However, there is not an optimal approach for the culture of primary mouse es
Externí odkaz:
https://doaj.org/article/b682bff1fe674f6bb6632a8523295d05
Autor:
Biyun Zheng, Kyung-Pil Ko, Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103440- (2021)
Summary: Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached. Moreover, organoid models reproducing esophageal squamous cell carcinoma (ESCC) initiation h
Externí odkaz:
https://doaj.org/article/68eefaa00f0d4a1d8e3b99253eb5f347
Autor:
Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Youn-Sang Jung, Kwon-Sik Park, Jae-Il Park
Publikováno v:
bioRxiv
Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, lung adenocarcinoma (LUAD) cells transform into neuroendocrinal (NE) tumor cells. However, the mechanisms of NE cell plasticity remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49c0202ce763c03300f67d882d9dd9e
https://europepmc.org/articles/PMC10153265/
https://europepmc.org/articles/PMC10153265/
Autor:
Zou Gengyi, Huang Yuanjian, Shengzhe Zhang, Kyung-Pil Ko, Bong Jun Kim, Jie Zhang, Melissa P. Pizzi, Yibo Fan, Sohee Jun, Na Niu, Huamin Wang, Shumei Song, Jaffer A. Ajani, Jae-Il Park
Diffuse-type gastric adenocarcinoma (DGAC) is lethal cancer often diagnosed late and resistant to therapeutics. Although hereditary DGAC is mainly characterized by mutations in theCDH1gene encoding E-cadherin, the impact of E-cadherin inactivation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ecf2d33baf504f0cff43c1670fd824d
https://doi.org/10.1101/2023.03.23.533976
https://doi.org/10.1101/2023.03.23.533976
Autor:
Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Haiyang Zhang, Hiroshi Nakagawa, Jae-Il Park
Publikováno v:
bioRxiv
SummaryDespite the promising outcomes of immune checkpoint blockade (ICB), resistance to ICB presents a new challenge. Therefore, selecting patients for specific ICB applications is crucial for maximizing therapeutic efficacy. Herein we curated 69 hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a74326848f597eda23a7463ce2e500a
https://doi.org/10.1101/2023.02.15.528539
https://doi.org/10.1101/2023.02.15.528539
Autor:
Shengzhe Zhang, Kee-Beom Kim, Yuanjian Huang, Dong-Wook Kim, Bongjun Kim, Kyung-Pil Ko, Gengyi Zou, Jie Zhang, Sohee Jun, Nicole A. Kirk, Ye Eun Hwang, Young Ho Ban, Joseph M. Chan, Charles M. Rudin, Kwon-Sik Park, Jae-Il Park
The mechanisms underlying immune evasion and immunotherapy resistance in small cell lung cancer (SCLC) remain unclear. Herein, we investigate the role of CRACD tumor suppressor in SCLC. We found that CRACD is frequently inactivated in SCLC, andCracdk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eda04b6e683f50752413a1ed3c9c21e
https://doi.org/10.1101/2023.02.15.528365
https://doi.org/10.1101/2023.02.15.528365
Autor:
Kyung-Pil Ko, Yuanjian Huang, Shengzhe Zhang, Gengyi Zou, Bongjun Kim, Jie Zhang, Sohee Jun, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Jae-Il Park
Background and aimsDespite recent progress in identifying aberrant genetic and epigenetic alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC initiation remains unknown.MethodsUsing CRISPR/Cas 9-based genetic ablation, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c822679c3b37a6177b3a5052f10d0b
https://doi.org/10.1101/2022.10.13.512143
https://doi.org/10.1101/2022.10.13.512143
Autor:
Wenyi Luo, Xiao-Zhong Wang, Jie Zhang, Xue-Fen Fang, Biyun Zheng, Kyung-Pil Ko, Youn Sang Jung, Bong-Jun Kim, Christopher L. Cervantes, Moon Jong Kim, Jae Il Park, Sohee Jun
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103440-(2021)
iScience, Vol 24, Iss 12, Pp 103440-(2021)
Summary Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached. Moreover, organoid models reproducing esophageal squamous cell carcinoma (ESCC) initiation ha