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Autor:
Asesh Banerjee, G.W. de Lisle, V. Balasubramanian, Annaik Quemard, E. Dubnau, Kyung Sun Um, Desmond M. Collins, T. Wilson, William R. Jacobs
Publikováno v:
Science. 263:227-230
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of action on Mycobacterium tuberculosis is unknown. A missense mutation within the mycobacterial inhA gene was shown to confer