Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS.

Autor: Eun Sil Kang, Jung Seok Hwang, Won Jin Lee, Gyeong Hee Lee, Mi-Jung Choi, Kyung Shin Paek, Dae-Seog Lim, Han Geuk Seo

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210482 (2019)

We investigated the effect of peroxisome proliferator-activated receptor δ (PPARδ) on angiotensin II (Ang II)-triggered hypertrophy of vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand of PPARδ, significantl

Externí odkaz: https://doaj.org/article/353cffe9a4184f249c0c4b4631e744b6

Activation of Peroxisome Proliferator-Activated Receptor γ by Rosiglitazone Inhibits Lipopolysaccharide-Induced Release of High Mobility Group Box 1

Autor: Jung Seok Hwang, Eun Sil Kang, Sun Ah Ham, Taesik Yoo, Hanna Lee, Kyung Shin Paek, Chankyu Park, Jin-Hoi Kim, Dae-Seog Lim, Han Geuk Seo

Publikováno v: Mediators of Inflammation, Vol 2012 (2012)

Peroxisome proliferator-activated receptors (PPARs) are shown to modulate the pathological status of sepsis by regulating the release of high mobility group box 1 (HMGB1), a well-known late proinflammatory mediator of sepsis. Ligand-activated PPARs m

Externí odkaz: https://doaj.org/article/49a66d67f3344c26a6ee1da9780e6ee3

Rosiglitazone‐dependent dissociation of HuR from PPAR‐γ regulates adiponectin expression at the posttranscriptional level

Autor: Gyeong Hee Lee, Won Jin Lee, Mi-Jung Choi, Eunsu Kim, Han Geuk Seo, Jung Seok Hwang, Dae-Seog Lim, Kyung Shin Paek, Jinwoo Hur, Hyuk Gyoon Lee

Publikováno v: The FASEB Journal. 33:7707-7720

Peroxisome proliferator-activated receptor (PPAR)-γ has been implicated as a key player in the regulation of adiponectin levels via both transcriptional and posttranscriptional mechanisms. Herein, we show that PPAR-γ interacts with human antigen R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e2a494848eb7487e11a88fbd3633a0
https://doi.org/10.1096/fj.201802643r

A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release

Autor: Won Jin Lee, Taesik Yoo, Sun Ah Ham, Jung Seok Hwang, Hyuk Soo Choi, Ho-Chul Shin, Kyung Shin Paek, Jin-A Park, Han Geuk Seo, Chi-Ho Lee

Publikováno v: BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-12 (2017)
BMC Complementary and Alternative Medicine
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(17)

Background Dalbergia odorifera T. Chen (Leguminosae) is an indigenous medicinal herb that is widely used as a popular remedy in northern and eastern Asia. However, the cellular mechanisms underlying the biological activity of D. odorifera are not ful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19747fc094ce11592a301b09fba2dd40
http://link.springer.com/article/10.1186/s12906-017-1725-0

Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner

Autor: Won Jin, Lee, Sun Ah, Ham, Gyeong Hee, Lee, Mi-Jung, Choi, Hyunjin, Yoo, Kyung Shin, Paek, Dae-Seog, Lim, Kwonho, Hong, Jung Seok, Hwang, Han Geuk, Seo

Publikováno v: Journal of neurochemistryReferences. 151(3)

Neuronal expression of beta-secretase 1 (BACE1) has been implicated in the progression of Alzheimer's disease. However, the mechanisms that regulate BACE1 expression are unclear. Here, we show that peroxisome proliferator-activated receptor delta (PP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15105e9724b9e4307dde19e3c8791405
https://pubmed.ncbi.nlm.nih.gov/31063584