Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Kyung Jin Yoo"'
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Data from CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity
Autor: Taylor H. Schreiber, Kaiwen Huang, Kyung Jin Yoo, Arpita Patel, Kellsey Johannes, Casey W. Shuptrine, George Fromm, Suresh de Silva
Disrupting the binding of CD47 to SIRPα has emerged as a promising immunotherapeutic strategy for advanced cancers by potentiating antibody-dependent cellular phagocytosis (ADCP) of targeted antibodies. Preclinically, CD47/SIRPα blockade induces an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f925ce040d128dd8677e8012432388
https://doi.org/10.1158/2326-6066.c.6550477
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7
Cutting Edge: Bispecific γδ T Cell Engager Containing Heterodimeric BTN2A1 and BTN3A1 Promotes Targeted Activation of Vγ9Vδ2(+) T Cells in the Presence of Costimulation by CD28 or NKG2D
Autor: Anne Y. Lai, Arpita Patel, Faraha Brewer, Kinsley Evans, Kellsey Johannes, Louis E. González, Kyung Jin Yoo, George Fromm, Keith Wilson, Taylor H. Schreiber, Suresh de Silva
Publikováno v: J Immunol
Vγ9Vδ2+ T cell–targeted immunotherapy is of interest to harness its MHC-independent cytotoxic potential against a variety of cancers. Recent studies have identified heterodimeric butyrophilin (BTN) 2A1 and BTN3A1 as the molecular entity providing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f09dab9f4b3b04d15e838c2cfb4e10
https://europepmc.org/articles/PMC9527206/
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8
LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade
Autor: Kyung Jin Yoo, Kellsey Johannes, Louis E. González, Arpita Patel, Casey W. Shuptrine, Zachary Opheim, Karen Lenz, Kristen Campbell, Thuy-Ai Nguyen, Jayalakshmi Miriyala, Connor Smith, Ashlyn McGuire, Yi-Hsuan Tsai, Fatima Rangwala, Suresh de Silva, Taylor H. Schreiber, George Fromm
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 209(3)
Coinhibition of TIGIT (T cell immunoreceptor with Ig and ITIM domains) and PD-1/PD-L1 (PD-1/L1) may improve response rates compared with monotherapy PD-1/L1 blockade in checkpoint naive non–small cell lung cancer with PD-L1 expression >50%. TIGIT m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dc81a687ad73128de2b026d23b8fe3
https://pubmed.ncbi.nlm.nih.gov/35817517
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9
Abstract 4214: LIGHT (TNFSF14) costimulation with TIGIT blockade broadens the activity of checkpoint inhibitors (CPIs) into CPI refractory and resistant tumors through targeted myeloid cell and effector lymphocyte activation
Autor: Kyung Jin Yoo, Louis Gonzalez, Kellsey Johannes, Jayalakshmi Miriyala, Karen Lenz, Kristen Campbell, Suresh de Silva, Taylor H. Schreiber, George J. Fromm
Publikováno v: Cancer Research. 82:4214-4214
Although increased TIGIT expression on TILs is associated with poor survival in patients with cancer, monotherapy TIGIT antibody blockade has not yet demonstrated significant clinical activity. PD-1 is commonly co-expressed on TILs, and PD-1 mediated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39e09824ac49b31f01e7cafe3d5c1af8
https://doi.org/10.1158/1538-7445.am2022-4214
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10
Abstract 3514: Bispecific gamma delta T cell engagers containing butyrophilin 2A1/3A1 heterodimeric fusion protein efficiently activate Vg9Vd2 T cells and promote tumor cell killing
Autor: Anne Lai, Arpita Patel, Faraha Brewer, Kinsley Evans, Kellsey Johannes, Louis Gonzalez, Kyung Jin Yoo, George Fromm, Keith Wilson, Taylor H. Schreiber, Suresh de Silva
Publikováno v: Cancer Research. 82:3514-3514
A primary mechanism of cancer immunotherapy resistance involves downregulation of specific antigens or major histocompatibility complex (MHC) based antigen presentation, which renders tumor cells invisible to αβ T cells, but not γδ T cells. Recen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63aa536cf9051f40f5231d9d02b382c9
https://doi.org/10.1158/1538-7445.am2022-3514
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