Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Kyung H. Choi"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract During HIV infection, specific RNA-protein interaction between the Rev response element (RRE) and viral Rev protein is required for nuclear export of intron-containing viral mRNA transcripts. Rev initially binds the high-affinity site in ste
Externí odkaz:
https://doaj.org/article/f858a5657fb84fe398c755927e4afd6d
Autor:
Eunhye Lee, Paul J. Bujalowski, Tadahisa Teramoto, Keerthi Gottipati, Seth D. Scott, Radhakrishnan Padmanabhan, Kyung H. Choi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, iden
Externí odkaz:
https://doaj.org/article/acf8de90f3514ec8ab19ff937e51ff75
Autor:
Kyung H. Choi
Publikováno v:
Viruses, Vol 13, Iss 6, p 1107 (2021)
An essential challenge in the lifecycle of RNA viruses is identifying and replicating the viral genome amongst all the RNAs present in the host cell cytoplasm. Yet, how the viral polymerase selectively recognizes and copies the viral RNA genome is po
Externí odkaz:
https://doaj.org/article/4771adbda4ec44368fbd47bafd46b713
Autor:
Emilio Reyes-Aldrete, Erik A. Dill, Cecile Bussetta, Michal R. Szymanski, Geoffrey Diemer, Priyank Maindola, Mark A. White, Wlodzimierz M. Bujalowski, Kyung H. Choi, Marc C. Morais
Publikováno v:
Viruses, Vol 13, Iss 1, p 15 (2020)
Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome
Externí odkaz:
https://doaj.org/article/5d2cc0d9e5a8459aacb41316ef643805
Publikováno v:
Antiviral research.
Flaviviruses are important human pathogens and include dengue (DENV), West Nile (WNV), Yellow fever virus (YFV), Japanese encephalitis (JEV) and Zika virus (ZIKV). DENV, transmitted by mosquitoes, causes diseases ranging in severity from mild dengue
Autor:
Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B Sherman, Kyung H Choi, Girish Neelakanta, Hameeda Sultana
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006764 (2018)
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes ext
Externí odkaz:
https://doaj.org/article/e38ce0540a6b42aeb5f460528cb3c817
Autor:
Valerie J Klema, Krishna Mohan Sepuru, Nadia Füllbrunn, Tierra R Farris, Paige S Dunphy, Jere W McBride, Krishna Rajarathnam, Kyung H Choi
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194891 (2018)
Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, secretes several effector proteins that bind host DNA to modulate host gene expression. The tandem repeat protein 120 (TRP120), one of the largest effector proteins, has
Externí odkaz:
https://doaj.org/article/323364a3ba5543abb73cfd9c9cb18991
Publikováno v:
Viruses, Vol 7, Iss 8, Pp 4640-4656 (2015)
Genome replication in flavivirus requires (—) strand RNA synthesis, (+) strand RNA synthesis, and 5’-RNA capping and methylation. To carry out viral genome replication, flavivirus assembles a replication complex, consisting of both viral and host
Externí odkaz:
https://doaj.org/article/3cf1b8e44f03466ea0d241b88a40f249
Autor:
Valerie J Klema, Mengyi Ye, Aditya Hindupur, Tadahisa Teramoto, Keerthi Gottipati, Radhakrishnan Padmanabhan, Kyung H Choi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005451 (2016)
Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the c
Externí odkaz:
https://doaj.org/article/77e014d574f84f2891aad1e42679194f
Autor:
William K. Russell, Hongjie Xia, Christian G. Noble, Mark A. White, Pei Yong Shi, Luis Marcelo F. Holthauzen, Kyung H. Choi, Jing Zou, Xuping Xie
Publikováno v:
Proc Natl Acad Sci U S A
Dengue virus (DENV) was designated as a top 10 public health threat by the World Health Organization in 2019. No clinically approved anti-DENV drug is currently available. Here we report the high-resolution cocrystal structure (1.5 Å) of the DENV-2