Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kyung Dall Lee"'
Autor:
Gordon L. Amidon, Kefeng Sun, Kyung Dall Lee, Hao Xu, Chester J. Provoda, Hairat Sabit, John L. Hilfinger
Publikováno v:
Molecular Pharmaceutics. 15:410-419
The prodrug strategy has been frequently employed as a chemical approach for overcoming the disadvantages of existing parent drugs. In this report, we synthesized four monoester prodrugs of ganciclovir, an anticytomegalovirus drug, and demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376b2dbc0e5becba89c42b3ede117f9f
https://doi.org/10.1021/acs.molpharmaceut.7b00792
https://doi.org/10.1021/acs.molpharmaceut.7b00792
Publikováno v:
Molecular Pharmaceutics
To improve the efficiency of gene delivery for effective gene therapy, it is essential that the vector carries functional components that can promote overcoming barriers in various steps leading to the transport of DNA from extracellular to ultimatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e2216834eec612809f722dd56a31a
http://europepmc.org/articles/PMC4319693
http://europepmc.org/articles/PMC4319693
Autor:
Deepak Gupta, John M. Hilfinger, Jing Sun, Gordon L. Amidon, Arik Dahan, Sheeba Varghese Gupta, Kyung Dall Lee, Yasuhiro Tsume
Publikováno v:
Molecular Pharmaceutics. 8:2358-2367
The purpose of this study was to improve the membrane permeability and oral absorption of the poorly permeable anti-influenza agent, zanamivir. The poor oral bioavailability is attributed to the high polarity (cLogP ∼ -5) resulting from the polar a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff777ffbead5c3f7b1287885b807ee85
https://doi.org/10.1021/mp200291x
https://doi.org/10.1021/mp200291x
Publikováno v:
Journal of Controlled Release. 148:219-225
Enhanced in vivo gene expression using non-viral vectors is a critical issue in gene therapy in general. Among the many potential utilities of non-viral vector-mediated gene delivery, its application in DNA-based vaccination is an attractive approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723344a50c9b427147f2c363926b7cd7
https://doi.org/10.1016/j.jconrel.2010.06.017
https://doi.org/10.1016/j.jconrel.2010.06.017
Autor:
Kyung Dall Lee, Suna Choi
Publikováno v:
Journal of Controlled Release. 131:70-76
One of the most important requirements for non-viral gene delivery systems is the ability to mediate high levels of gene expression with low toxicity. After the DNA/vector complexes are taken up by cells through endocytosis, DNA is typically containe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144929ff4e8ed201bb36f277105edbbf
https://doi.org/10.1016/j.jconrel.2008.07.007
https://doi.org/10.1016/j.jconrel.2008.07.007
Publikováno v:
Journal of Biological Chemistry. 283:9318-9327
Chemical modification to improve biopharmaceutical properties, especially oral absorption and bioavailability, is a common strategy employed by pharmaceutical chemists. The approach often employs a simple structural modification and utilizes ubiquito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b19f7ea6c8c174a4e4879be73a56ffc
https://doi.org/10.1074/jbc.m709530200
https://doi.org/10.1074/jbc.m709530200
Autor:
Robert L. Coffman, Franck J. Barrat, Jean H. Chan, Carlo Calacsan, Emily Damon, Tracy Matray, Cristiana Guiducci, Gary Ott, Kyung Dall Lee
Publikováno v:
The Journal of Experimental Medicine
Human plasmacytoid dendritic cells (PDCs) can produce interferon (IFN)-alpha and/or mature and participate in the adaptive immune response. Three classes of CpG oligonucleotide ligands for Toll-like receptor (TLR)9 can be distinguished by different s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f71781998d337cd83c235ad294eff7
https://doi.org/10.1084/jem.20060401
https://doi.org/10.1084/jem.20060401
Autor:
Gretchen L. Lorenzi, Kyung Dall Lee
Publikováno v:
The Journal of Gene Medicine. 7:1077-1085
Background A major obstacle to achieving effective DNA-based therapeutics is efficient delivery of the DNA to its site of action in the cell. Upon internalization by endocytosis, the endosomal membrane represents a critical physical barrier preventin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaaa8956e498365edca8173cf7dbe5c
https://doi.org/10.1002/jgm.750
https://doi.org/10.1002/jgm.750
Publikováno v:
Journal of Biotechnology. 164:500-502
Delivery of macromolecules into the cytosolic space of eukaryotic cells is a pressing challenge in biopharmaceutics. Macromolecules are often encapsulated into liposomes for protection and improved distribution, but the their size often induces endoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2aa93204dfac34793c5edc145c4487
https://doi.org/10.1016/j.jbiotec.2013.01.029
https://doi.org/10.1016/j.jbiotec.2013.01.029
Publikováno v:
Molecular Pharmaceutics. 2:74-82
Delivery of antigenic protein to the cytosol of antigen-presenting cells (APCs), such as macrophages (MPhi) and dendritic cells (DCs), is required for an efficient CD8 T-cell-mediated immune response. We have previously shown that co-encapsulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0583a4be9adff0541c158a2813ae266
https://doi.org/10.1021/mp049896v
https://doi.org/10.1021/mp049896v