Photodecarboxylation of DX-9065a, a New Factor Xa Inhibitor, in Aqueous Solution

Autor: Kyuichi Matsubayashi, Yukinori Kawai

Publikováno v: Chemical and Pharmaceutical Bulletin. 46:131-135

The photodegradation reaction of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3- (7-amidino-2-naphthyl) propanoic acid hydrochloride pentahydrate (DX-9065a), a new factor Xa inhibitor, was investigated in aqueous solution at various pH v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394f2a0f31858cb873838f67f2da3b39
https://doi.org/10.1248/cpb.46.131

Interaction of Quinolones with Metal Cations in Aqueous Solution

Autor: Hideo Hakusui, Kyuichi Matsubayashi, Yukinori Kawai

Publikováno v: Chemical and Pharmaceutical Bulletin. 44:1425-1430

Quinolones are a group of potent antibacterial agents. Many reports show that oral absorption of quinolones is reduced by coadministration of metallic preparations. For better understanding of this phenomenon, we investigated the complex formations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9add37fb75b48ed477ee0f8ac0b251
https://doi.org/10.1248/cpb.44.1425

Contents, Vol. 38, 1992

Autor: George G. Zhanel, Shinjiro Hashimoto, K. Kyriakis, Isola, A.F. Mentis, B. Joly, Atsushi Saito, Yasuaki Osadd, Ross J. Davidson, Arcangelo, A. Quaglietta, Richard Greenberg, Antonio, Kyuichi Matsubayashi, G. Gialdroni Grassi, Mary H. May, S. Betti, K.D. Bremm, Alfred J. Crowle, R. Di Gianfilippo, K.G. Metzger, Martínez Díaz, Gómez Barrio, A. Tsakris, Daryl J. Hoban, Robert H. K. Eng, George S. Douvas, Hishama Saldin, A. Spadano, Sung Kim, P. Accorsi, U. Petersen, J. Rodríguez, A. Piergallini, M. Dell, R. Endermann, R. Cluzel, J. Atienza, Charles E. Cherubin, C. Jallat, Jingoro Shimada, Hussain Qadri, A. Recchia, J.A. Escario, Diane M. Citron, Sharon M. Smith, Kenneth Yen, Ellie J. C. Goldstein, Kumi Yoshida, Osamu Sakai, A. Fietta, C. Mastrangelo, P. Boeri, C. Forestier, A. Iacone, Saleh R. Al-Ballaa, D. Natale, Yoshio Ueno, Kohya Shiba, Lindsay E. Nicolle, N.J. Legakis, Joanne Crampton, L.S. Tzouvelekis, A. Darfeuille-Michaud, C. Ochoa, A. Herrero, Masaki Yoshida, E. Tzelepi, G. Fioritoni, G. Torlontano, M.L. Colombo, C. Merlini

Publikováno v: Chemotherapy. 38:I-VI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c5102dca0b1667d5096e47ef99a4fc3
https://doi.org/10.1159/000239028

Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam

Autor: Yuri Tominaga, Toshimasa Jindo, Kyuichi Matsubayashi, Yoshimi Tsuchiya, Kazuo T. Suzuki, Kazuhisa Furuhama

Publikováno v: Archives of toxicology. 79(9)

The occurrence of renal papillary necrosis (RPN), seen only in dogs after repeated oral administration of nefiracetam, a neurotransmission enhancer, at a relatively high dose, is because of inhibition of renal prostaglandin synthesis by the nefiracet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3dd467b3c6c1699bb1bcc6e0e954c60
https://pubmed.ncbi.nlm.nih.gov/16007418

Nonlinear pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in rats caused by non-Michaelis-Menten type, dose-dependent renal clearance

Autor: Shozo Shintani, Haruo Tachizawa, Kyuichi Matsubayashi, Masayoshi Yamada, Kumi Yoshida

Publikováno v: Journal of pharmaceutical sciences. 83(2)

□ The pharmacokinetics and its dose dependency of a new cephalosporin, DQ-2556, were studied in the rat and rabbit. The pharmacokinetics of the compound In the rat was linear up to a dose of 300 mg/kg; however, at a dose of 1200 mg/kg, renal cleara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44b24a8bf0d15b19c91dcf3799e078c
https://pubmed.ncbi.nlm.nih.gov/8169786