Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Kyu Sung Jeong"'
Autor:
Jieon Hwang, Areum Park, Chinwoo Kim, Chang Gon Kim, Jaesung Kwak, Byungil Kim, Hyunjin Shin, Minhee Ku, Jaemoon Yang, Ayoung Baek, Jiwon Choi, Hocheol Lim, Kyoung Tai No, Xianghua Zhao, Uyeong Choi, Tae Il Kim, Kyu-Sung Jeong, Hyuk Lee, Sang Joon Shin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Dysregulation of iron metabolism is implicated in malignant transformation, cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory protein 2 (IRP2) preferentially regulates iron metabolism and pr
Externí odkaz:
https://doaj.org/article/610071ff27cb47faa5ea555a2fd21739
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The development of synthetic receptors capable of selectively binding guests with diverse structures and multiple functional groups poses a significant challenge. Here, we present the efficient assembly of foldamer-based receptors for monosa
Externí odkaz:
https://doaj.org/article/d3ec30386c534b4abc1fce2722fb6b8f
Publikováno v:
ACS Omega, Vol 6, Iss 9, Pp 6498-6508 (2021)
Externí odkaz:
https://doaj.org/article/c1f6ef888f7e428a8267c33d07029fd6
Autor:
Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G. Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1460-1471 (2018)
The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain. Several potent T-type channel inhibitors showed promising in vivo efficacy in neuropathic p
Externí odkaz:
https://doaj.org/article/a75094cd1879498e85b97dd69a6730cb
Publikováno v:
Chemical Communications. 58:1410-1413
Helical folding of a carbazole–pyridine oligomer generates a tweezer-type binding cavity which allows for the intercalation of a naphthalenediimide guest.
Autor:
JIEON HWANG, AREUM PARK, CHINWOO KIM, DANBI YU, HYUNGJU BYUN, MINHEE KU, JAEMOON YANG, TAE IL KIM, KYU-SUNG JEONG, KI YOUNG KIM, HYUK LEE, SANG JOON SHIN
Publikováno v:
Anticancer Research. 42:589-598
We previously identified KS40008 (4-(3-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)benzene-1,2-diol), a novel inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase family (DYRK) 1A/B, which exhibited high enzymatic activity and
Publikováno v:
Chemistry – An Asian Journal. 16:2958-2966
Aromatic helical receptors P-1 and P-2 were slightly modified by aerobic oxidation to afford new receptors P-7 and P-8 with right-handed helical cavities. This subtle modification induced significant changes in the binding properties for chiral guest
Publikováno v:
ACS Omega, Vol 6, Iss 9, Pp 6498-6508 (2021)
We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of
Publikováno v:
Angewandte Chemie. 132:10527-10531
As a synthetic model for intra-protein interactions that reinforce binding affinities between proteins and ligands, the energetic interplay of binding and folding was investigated using foldamer-based receptors capable of adopting helical structures.
Autor:
Jaehee Kim, Areum Park, Jieon Hwang, Xianghua Zhao, Jaesung Kwak, Hyun Woo Kim, Minhee Ku, Jaemoon Yang, Tae Il Kim, Kyu-Sung Jeong, Uyeong Choi, Hyuk Lee, Sang Joon Shin
Publikováno v:
Cell Reports. 40:111077
Redox-active metal ions are pivotal for rapid metabolism, proliferation, and aggression across cancer types, and this presents metal chelation as an attractive cancer cell-targeting strategy. Here, we identify a metal chelator, KS10076, as a potent a