Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kyu Myung Lee"'
Autor:
Seong Hun Jang, Dakshinamurthy Sivakumar, Sathish Kumar Mudedla, Jaehan Choi, Sungmin Lee, Minjun Jeon, Suneel Kumar Bvs, Jinha Hwang, Minsung Kang, Eun Gyeong Shin, Kyu Myung Lee, Kwan-Young Jung, Jae-Sung Kim, Sangwook Wu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Treating acute myeloid leukemia (AML) by targeting FMS-like tyrosine kinase 3 (FLT-3) is considered an effective treatment strategy. By using AI-assisted hit optimization, we discovered a novel and highly selective compound with desired drug-like pro
Externí odkaz:
https://doaj.org/article/445be06eed3e476b882a2ba5e5bb36c0
Autor:
Minsung Kang, Navin Pandit, Ah-Young Kim, Suk Joon Cho, Young-Ju Kwon, Jiyeon Ahn, Kyu Myung Lee, Sangwook Wu, Jeong Su Oh, Kwan-Young Jung, Jae-Sung Kim
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field. This study describes a novel pyrazole derivative that exer
Externí odkaz:
https://doaj.org/article/4db7d44355174c20958e4f145bd37aea
Autor:
Minjin Yoo, Tae Hyun Park, Miyoun Yoo, Yeongrin Kim, Joo-Youn Lee, Kyu Myung Lee, Seong Eon Ryu, Byung Il Lee, Kwan-Young Jung, Chi Hoon Park
Publikováno v:
Molecules, Vol 26, Iss 6, p 1686 (2021)
Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression. There has been increasing interest in bromodomain owing to its ability to modul
Externí odkaz:
https://doaj.org/article/7126f47094d24e8fad469e64c65ac9b2
Publikováno v:
Physical Review B. 107
Publikováno v:
SID Symposium Digest of Technical Papers. 53:512-514
Autor:
Navin Pandit, Miyoun Yoo, Tae Hyun Park, Jiin Kim, Seul Mi Kim, Kyu Myung Lee, Yeongrin Kim, Seoung Min Bong, Byung Il Lee, Kwan-Young Jung, Chi Hoon Park
Publikováno v:
Bioorganicmedicinal chemistry. 72
Bromodomain and extra-terminal domain (BET) proteins have been considered as potent candidates for anti-cancer drug development. As epigenetic readers, they modulate gene expression by recognizing acetylated lysine residues on histones. Therefore, th
Autor:
Woojin Jeon, Jong Am Hong, Jun Hyung Jeong, Seong Jun Kang, Sungho Park, Tae Yeon Kim, Yongsup Park, Kyu Myung Lee, Eui Young Jung, Byung Jun Kim
Publikováno v:
RSC Advances. 11:12051-12057
Visible-light phototransistors have been fabricated based on the heterojunction of zinc oxide (ZnO) and titanium oxide (TiO2). A thin layer of TiO2 was deposited onto the spin-coated ZnO film via atomic layer deposition (ALD). The electrical characte
Autor:
Byung Jun Kim, Woojin Jeon, Seong Jun Kang, Eui Young Jung, Kyu-Myung Lee, Tae Yeon Kim, Jong-Am Hong, Yongsup Park, Sungho Park
Publikováno v:
Journal of Materials Chemistry C. 9:2550-2560
We have developed a visible-light phototransistor with excellent photodetection characteristics and stability via atomic layer deposition (ALD) to add a thin layer of aluminum oxide (Al2O3) to quantum dot (QD)/zinc oxide (ZnO) films. Al2O3 was used t
Autor:
Minsung Kang, Navin Pandit, Ah-Young Kim, Suk Joon Cho, Young-Ju Kwon, Jiyeon Ahn, Kyu Myung Lee, Sangwook Wu, Jeong Su Oh, Kwan-Young Jung, Jae-Sung Kim
Publikováno v:
Frontiers in oncology. 12
As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field. This study describes a novel pyrazole derivative that exer
Autor:
Mahesh Dighe, Jin Hee Ahn, Myung Ae Bae, Haushabhau S. Pagire, Eun Jung Bae, Sungmi Park, Kwan-Young Jung, Hee Eon Gim, Seungmi Lee, Tae-Ho Lee, Suvarna H. Pagire, Kwang-Hyeon Liu, Young In Chi, Ga-Hyun Lee, Kyu Myung Lee, Jin Sook Song, Ashok Kumar Jaladi, Minhee Kim, Yong Hyun Jeon, Jae-Han Jeon, Eun Kyung Yoo, Inkyu Lee, Dahye Lee, Won-Il Choi, Yoon Kyung Jang
Publikováno v:
Journal of Medicinal Chemistry. 62:575-588
Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. Structural modifications of hit anthraquinone led to the identification of a new series of all