Výsledky vyhledávání - "Kyrstin Datanagan"

Akademický článek

Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

Autor: Yinsong Zhu, Peibin Yue, Cody F. Dickinson, Justin K. Yang, Kyrstin Datanagan, Ning Zhai, Yi Zhang, Gabriella Miklossy, Francisco Lopez-Tapia, Marcus A. Tius, James Turkson

Publikováno v: Cell Death and Disease, Vol 13, Iss 12, Pp 1-14 (2022)

Abstract Dysregulated gene expression programs and redox and metabolic adaptations allow cancer cells to survive under high oxidative burden. These mechanisms also represent therapeutic vulnerabilities. Using triple-negative breast cancer (TNBC) as a

Externí odkaz: https://doaj.org/article/d34229ea9bfc4181a22308db8241c982

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Abstract 5482: Natural product inhibitor of Stat3, G6PD, and TrxR1 functions induces an early oxidative stress and pyroptosis, and a late-stage DNA damage and cell cycle arrest to block tumor growth in human breast cancer models

Autor: Yinsong Zhu, Cody F. Dickinson, Justin Yang, Kyrstin Datanagan, Ning Zhai, Peibin Yue, Francisco Lopez-Tapia, Marcus A. Tius, James Turkson

Publikováno v: Cancer Research. 82:5482-5482

Bioactive natural products have led to new drugs or been the inspiration for developing new treatments. Signal transducer and activator of transcription (STAT)3 is a an oncogene that has been implicated in many human cancers. We report that the hirsu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed993d5083d3fe1d4a6943d68393795f
https://doi.org/10.1158/1538-7445.am2022-5482

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