Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kyriakos Pratis"'
Autor:
Ulrich Gottwald, Gabriele Leder, Robert I McLachlan, Jörg Müller, Peter G. Stanton, Liza O'Donnell, Andrea Wagenfeld, Kyriakos Pratis
Publikováno v:
Endocrinology. 150:5074-5084
Spermatogenesis occurs within the highly complex seminiferous epithelium. This cyclic process is accompanied by dynamic stage-specific transcriptional changes and is driven by androgens and FSH by mechanisms that are unclear. Here we report the impac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356e0f59a3bd5bb1f34c964965dc6dfc
https://doi.org/10.1210/en.2009-0755
https://doi.org/10.1210/en.2009-0755
Autor:
Liza O'Donnell, Rebecca J. Clifton, David Robertson, Kyriakos Pratis, Peter G. Stanton, Jessica Killian
Publikováno v:
Biology of Reproduction. 68:1711-1718
The pubertal initiation of spermatogenesis is reliant on androgens, and during this time, 5α-reduced androgens such as dihydrotestosterone (DHT) are the predominant androgens in the testis. Two 5α-reductase (5αR) isoenzymes (5αR1 and 5αR2) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3013072d4b3bdd4fc89d1e64d79a119
https://doi.org/10.1095/biolreprod.102.009142
https://doi.org/10.1095/biolreprod.102.009142
Autor:
Liza O'Donnell, Peter G. Stanton, Guck T. Ooi, Robert I McLachlan, David Robertson, Kyriakos Pratis
Publikováno v:
Journal of Endocrinology. 176:393-403
Testosterone is metabolised to the more potent androgen, dihydrotestosterone, by the 5alpha-reductase (5alphaR) enzyme. We previously showed that 5alpha-reduced androgens are important for maintaining androgen action on rat spermatogenesis when testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d003a112701609e4d31a3ab0228f783c
https://doi.org/10.1677/joe.0.1760393
https://doi.org/10.1677/joe.0.1760393
Publikováno v:
Endocrinology. 145(4)
The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to a disruption to the Cyp19 gene. Previously we have shown both male and female ArKO mice have an age progressive obese phenotype and a sexually dimorphic disruption to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8ac0f00456acddd74c81688e27e5a5
https://pubmed.ncbi.nlm.nih.gov/14684602
https://pubmed.ncbi.nlm.nih.gov/14684602
Autor:
Jessica, Killian, Kyriakos, Pratis, Rebecca J, Clifton, Peter G, Stanton, David M, Robertson, Liza, O'Donnell
Publikováno v:
Biology of reproduction. 68(5)
The pubertal initiation of spermatogenesis is reliant on androgens, and during this time, 5alpha-reduced androgens such as dihydrotestosterone (DHT) are the predominant androgens in the testis. Two 5alpha-reductase (5alphaR) isoenzymes (5alphaR1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::801eefee685b68fc25718088d84e2826
https://pubmed.ncbi.nlm.nih.gov/12606426
https://pubmed.ncbi.nlm.nih.gov/12606426
Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man
Autor:
Robert I McLachlan, Peter G. Stanton, de Kretser Dm, Sarah J Meachem, Kyriakos Pratis, David Robertson, Liza O'Donnell
Publikováno v:
Recent progress in hormone research. 57
A detailed understanding of the hormonal regulation of spermatogenesis is required for the informed assessment and management of male fertility and, conversely, for the development of safe and reversible male hormonal contraception. An approach to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85692e58204109ca4bb5ecbaa556c016
https://pubmed.ncbi.nlm.nih.gov/12017541
https://pubmed.ncbi.nlm.nih.gov/12017541
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 75(1)
The relative abundance and physiological role of 5alpha-reductase (5alphaR) isoforms in rat testis, in particular 5alpha-reductase Type 2 (5alphaR2) are poorly understood. Investigation of 5alphaR2 activity using enzyme kinetic studies was hampered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a47c97cb9aa8bdce0191cfff751b4e
https://pubmed.ncbi.nlm.nih.gov/11179911
https://pubmed.ncbi.nlm.nih.gov/11179911
