Výsledky vyhledávání - "Kyriacos M. Koupparis"

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease

Autor: Kyriacos M. Koupparis, Iulia A. Kovari, Mark R. Spaller, Joseck M. Muhuhi, Krisztina Z. Bencze, Zhigang Liu, Ladislau C. Kovari, Ravikiran S. Yedidi, Carrie O'Connor

Publikováno v: Biochemical and biophysical research communications. 438(4)

Multidrug-resistant (MDR) clinical isolate-769, human immunodeficiency virus type-1 (HIV-1) protease (PDB ID: 1TW7), was shown to exhibit wide-open flaps and an expanded active site cavity, causing loss of contacts with protease inhibitors. In the cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e1471d1403d0ec0fb3c9028a6ecda
https://pubmed.ncbi.nlm.nih.gov/23921229

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