Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kyriacos M"'
Autor:
Bryan R. Gorman, Michael Francis, Cari L. Nealon, Christopher W. Halladay, Nalvi Duro, Kyriacos Markianos, Giulio Genovese, Pirro G. Hysi, Hélène Choquet, Natalie A. Afshari, Yi-Ju Li, VA Million Veteran Program, J. Michael Gaziano, Adriana M. Hung, Wen-Chih Wu, Paul B. Greenberg, Saiju Pyarajan, Jonathan H. Lass, Neal S. Peachey, Sudha K. Iyengar
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation, but its molecular etiology remains poorly understood. We performed genome-wide association studies (GWAS) of FECD in the Million Veteran Program
Externí odkaz:
https://doaj.org/article/0fe539b9cc3448d380d23ca144eee0cb
Autor:
Aladdin Bashir, Zaheer Tahir, Mahmood Ahmad, Kyriacos Mouyis, Ali Zuhair Kirresh, Sameh Atta, Clinton Lloyd, Malcolm Dalrymple-Hay
Publikováno v:
Monaldi Archives for Chest Disease (2024)
Tricuspid regurgitation (TR) is the most common pathology for the tricuspid valve. Moderate to severe TR is associated with morbidity and adverse outcomes. The concept that TR resolves on its own if the underlying disease is successfully treated has
Externí odkaz:
https://doaj.org/article/08e33de9e9d2468d9c9a788e4cfe61aa
Autor:
Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Both cell surface and soluble extracellular glycosaminoglycans have been shown to interfere with the exogenous nucleic acid delivery efficiency of non-viral gene delivery, including lipoplex and polyplex-mediated transfection. Most gene therapy viral
Externí odkaz:
https://doaj.org/article/30f18ce1f17f438ab64d69f10643272c
Autor:
Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101260- (2024)
Large-scale transient transfection has advanced significantly over the last 20 years, enabling the effective production of a diverse range of biopharmaceutical products, including viral vectors. However, a number of challenges specifically related to
Externí odkaz:
https://doaj.org/article/3197910bb8934f0bb12e559c15fef757
Autor:
Thomas Williams, Kevin Kalinka, Rui Sanches, Greg Blanchard-Emmerson, Samuel Watts, Lee Davies, Carol Knevelman, Laura McCloskey, Peter Jones, Kyriacos Mitrophanous, James Miskin, Duygu Dikicioglu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Process analytical technology (PAT) has demonstrated huge potential to enable the development of improved biopharmaceutical manufacturing processes by ensuring the reliable provision of quality products. However, the complexities associated
Externí odkaz:
https://doaj.org/article/5ba382014cbb4084ad4e23ec8b56f489
Autor:
Rosie J. Munday, Tiziana Coradin, Rachael Nimmo, Yatish Lad, Stephen C. Hyde, Kyriacos Mitrophanos, Deborah R. Gill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 239-252 (2022)
A lentiviral vector (LV) pseudotype derived from the fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of a murine respirovirus (Sendai virus) facilitates efficient targeting of murine lung in vivo. Since targeting of the human lung will
Externí odkaz:
https://doaj.org/article/241605041a2345d097db4e7ae694bd95
Autor:
Johanna Jones, Kyriacos Mouyis, Angelos Tyrlis, Krishnaraj S. Rathod, Oliver Guttmann, Andrew Wragg, Constantinos O'Mahony, Anthony Mathur, Andreas Baumbach, Daniel A. Jones
Publikováno v:
American Heart Journal Plus, Vol 30, Iss , Pp 100301- (2023)
Background: Drug eluting balloons (DEB) are a feasible method of rapid delivery of drug to a coronary vessel wall. Their efficacy has been established for the treatment of in-stent restenosis and small vessel disease but there is limited data for the
Externí odkaz:
https://doaj.org/article/04c6d2b3fb84424abb0f06b59b08e3ff
Autor:
Kyriacos Markianos, Frederic Dong, Bryan Gorman, Yunling Shi, Daniel Dochtermann, Uma Saxena, Poornima Devineni, Jennifer Moser, Sumitra Muralidhar, Rachel Ramoni, Philip Tsao, Saiju Pyarajan, Ronald Przygodzki, Million Veteran Program
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0274339 (2023)
We present allele frequencies of pharmacogenomics relevant variants across multiple ancestry in a sample representative of the US population. We analyzed 658,582 individuals with genotype data and extracted pharmacogenomics relevant single nucleotide
Externí odkaz:
https://doaj.org/article/bca5a95e90da42c3a3c49c3e4f346e91
Autor:
Kyriacos M. Koupparis, Iulia A. Kovari, Mark R. Spaller, Joseck M. Muhuhi, Krisztina Z. Bencze, Zhigang Liu, Ladislau C. Kovari, Ravikiran S. Yedidi, Carrie O'Connor
Publikováno v:
Biochemical and biophysical research communications. 438(4)
Multidrug-resistant (MDR) clinical isolate-769, human immunodeficiency virus type-1 (HIV-1) protease (PDB ID: 1TW7), was shown to exhibit wide-open flaps and an expanded active site cavity, causing loss of contacts with protease inhibitors. In the cu
Autor:
Sher May Ng, Jiliu Pan, Kyriacos Mouyis, Sreenivasa Rao Kondapally Seshasai, Vikas Kapil, Kenneth M. Rice, Ajay K. Gupta
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundMore than 80% of individuals in low and middle-income countries (LMICs) are unvaccinated against coronavirus disease 2019 (COVID-19). In contrast, the greatest burden of cardiovascular disease is seen in LMIC populations. Hypertension (HTN)
Externí odkaz:
https://doaj.org/article/a528cfff31594137ad584ec7a4ff5c53