Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kyra W Seiger"'
Autor:
Everett Webster, Kyra W. Seiger, Susan B. Core, Amanda L. Collar, Hannah Knapp-Broas, June Graham, Muskan Shrestha, Sarah Afzaal, William M. Geisler, Cosette M. Wheeler, Bryce Chackerian, Kathryn M. Frietze, Rebeccah S. Lijek
Publikováno v:
Vaccines, Vol 10, Iss 1, p 111 (2022)
An effective vaccine against Chlamydia trachomatis is urgently needed as infection rates continue to rise and C. trachomatis causes reproductive morbidity. An obligate intracellular pathogen, C. trachomatis employs a type 3 secretion system (T3SS) fo
Externí odkaz:
https://doaj.org/article/cb4b2e6027834ce38503b3a3850e2434
Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy
Autor:
Xiaodong Lian, Kyra W. Seiger, Elizabeth M. Parsons, Ce Gao, Weiwei Sun, Gregory T. Gladkov, Isabelle C. Roseto, Kevin B. Einkauf, Matthew R. Osborn, Joshua M. Chevalier, Chenyang Jiang, Jane Blackmer, Mary Carrington, Eric S. Rosenberg, Michael M. Lederman, Deborah K. McMahon, Ronald J. Bosch, Jeffrey M. Jacobson, Rajesh T. Gandhi, Michael J. Peluso, Tae-Wook Chun, Steven G. Deeks, Xu G. Yu, Mathias Lichterfeld
Publikováno v:
Cell Host & Microbe. 31:83-96.e5
HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile of long-term ART-treated individuals, characterized by large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db7197dd03a22a40972bf30c00d8e9
https://doi.org/10.1016/j.chom.2022.12.002
https://doi.org/10.1016/j.chom.2022.12.002
Autor:
Xiaodong Lian, Ce Gao, Xiaoming Sun, Chenyang Jiang, Kevin B. Einkauf, Kyra W. Seiger, Joshua M. Chevalier, Yuko Yuki, Maureen Martin, Rebecca Hoh, Michael J. Peluso, Mary Carrington, Ezequiel Ruiz-Mateos, Steven G. Deeks, Eric S. Rosenberg, Bruce D. Walker, Mathias Lichterfeld, Xu G. Yu
Publikováno v:
Science translational medicine, vol 13, iss 624
Sci Transl Med
Digital.CSIC. Repositorio Institucional del CSIC
instname
Sci Transl Med
Digital.CSIC. Repositorio Institucional del CSIC
instname
Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled by effective cellular immune responses that may induce an attenuated viral reservoir configuration with a weaker ability to drive viral rebound. Here, we comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495f54628c6609c1598c24ef192e5544
https://doi.org/10.1126/scitranslmed.abl4097
https://doi.org/10.1126/scitranslmed.abl4097
Autor:
Kevin B. Einkauf, Matthew R. Osborn, Ce Gao, Weiwei Sun, Xiaoming Sun, Xiaodong Lian, Elizabeth M. Parsons, Gregory T. Gladkov, Kyra W. Seiger, Jane E. Blackmer, Chenyang Jiang, Steven A. Yukl, Eric S. Rosenberg, Xu G. Yu, Mathias Lichterfeld
Publikováno v:
Cell
Cell, vol 185, iss 2
Cell, vol 185, iss 2
Summary HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently considered “transcriptionally silent,” but active viral gene expression may occur in some cells, challenging the concept of viral latency. Applying an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763ce6af9e41c26910a6540345abb1a2
http://europepmc.org/articles/PMC8809251
http://europepmc.org/articles/PMC8809251
Publikováno v:
Proceedings of the National Academy of Sciences. 115:2216-2221
Infection with Chlamydia trachomatis drives severe mucosal immunopathology; however, the immune responses that are required for mediating pathology vs. protection are not well understood. Here, we employed a mouse model to identify immune responses r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4f5be85534f4a8e481d9c812f9ec76
https://doi.org/10.1073/pnas.1711356115
https://doi.org/10.1073/pnas.1711356115
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(9)
Immunopathology after Chlamydia trachomatis infection is the major cause of human suffering associated with this pathogen, yet the immune responses that drive pathology are not well defined. We demonstrate that a mucosal influx of neutrophils and CXC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fbfedaae2e68bbdb1f28994f711bb25
https://pubmed.ncbi.nlm.nih.gov/29440378
https://pubmed.ncbi.nlm.nih.gov/29440378