Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyra Thrush"'
Autor:
Morgan Levine, Ross A McDevitt, Margarita Meer, Kathy Perdue, Andrea Di Francesco, Theresa Meade, Colin Farrell, Kyra Thrush, Meng Wang, Christopher Dunn, Matteo Pellegrini, Rafael de Cabo, Luigi Ferrucci
Publikováno v:
eLife, Vol 9 (2020)
Robust biomarkers of aging have been developed from DNA methylation in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages—by inc
Externí odkaz:
https://doaj.org/article/9defa62c224c4fb7801a05f0bb6add5b
Publikováno v:
Alzheimer's & Dementia. 18
Publikováno v:
Semin Cell Dev Biol
Quantifying biological aging is critical for understanding why aging is the primary driver of morbidity and mortality and for assessing novel therapies to counter pathological aging. In the past decade, many biomarkers relevant to brain aging have be
Autor:
Christopher J. Minteer, Kyra Thrush, Peter Niimi, Joel Rozowsky, Jason Liu, Mor Frank, Thomas McCabe, Erin Hofstatter, Mariya Rozenblit, Lajos Pusztai, Kenneth Beckman, Mark Gerstein, Morgan E. Levine
Aging is the leading risk factor for cancer. While it’s been proposed that the age-related accumulation of somatic mutations drives this relationship, it is likely not the full story. Here, we show that both aging and cancer share a common epigenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f556cef7cab06b70efa61744cc498d58
https://doi.org/10.1101/2022.09.14.507975
https://doi.org/10.1101/2022.09.14.507975
Autor:
Aesis Luna, Kyra Thrush
Publikováno v:
The FASEB Journal. 36
Epigenetic clocks have come to be regarded as powerful tools for estimating aging. However, a major drawback in their application is our lack of mechanistic understanding. We hypothesize that uncovering the underlying biology is difficult due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c300d9548e4017d24403e4b62b89733
https://doi.org/10.1101/2022.02.13.480245
https://doi.org/10.1101/2022.02.13.480245
Autor:
Christopher J. Minteer, Kyra Thrush, Peter Niimi, Joel Rozowsky, Jason Liu, Mor Frank, Thomas McCabe, Erin Hofstatter, Mariya Rozenblit, Lajos Pusztai, Kenneth Beckman, Mark Gerstein, Morgan E. Levine
Publikováno v:
Cancer Research. 83:PR009-PR009
Aging is the leading risk factor for cancer. While some have proposed that the age-related accumulation of somatic mutations drives this relationship, it is likely not the full story. Here, we show that both aging and cancer share a common epigenetic
Autor:
Stefania Bandinelli, Yunzhang Wang, Elbert Geuze, Eileen M. Crimmins, Christopher Minteer, Meng Wang, Stefanie Schreiter, Marco P. Boks, Albert T. Higgins-Chen, Ann Zenobia Moore, Pei-Lun Kuo, Morgan E. Levine, Jurjen J. Luykx, Marte Z. van der Horst, Bart P. F. Rutten, Sara Hägg, Kyra Thrush, Eric Vermetten, Luigi Ferrucci, Cynthia Okhuijsen-Pfeifer, Stefan Gutwinski, Christiaan H. Vinkers, Tina T. Hu-Seliger
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data. Unfortunately, measurements for individual CpGs can be surprisingly unreliable due to technical noise, and this may limit the utility of epigenetic clocks. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eea51c47e3e3aa0e65733fecc0ade2c
https://doi.org/10.1101/2021.04.16.440205
https://doi.org/10.1101/2021.04.16.440205
Autor:
Andrea Di Francesco, Luigi Ferrucci, Margarita Meer, Theresa Meade, Colin Farrell, Ross A. McDevitt, Kyra Thrush, Matteo Pellegrini, Christopher Dunn, Kathy A Perdue, Meng Wang, Rafael de Cabo, Morgan E. Levine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbb005b69fb799231ccef605622fc95
https://doi.org/10.7554/elife.59201.sa2
https://doi.org/10.7554/elife.59201.sa2
Autor:
Kathy A Perdue, Meng Wang, Christopher Dunn, Rafael de Cabo, Luigi Ferrucci, Ross A. McDevitt, Andrea Di Francesco, Kyra Thrush, Margarita Meer, Colin Farrell, Theresa Meade, Matteo Pellegrini, Morgan E. Levine
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Robust biomarkers of aging have been developed from DNA methylation in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages—by inc