Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyra N. Smit"'
Autor:
Kyra N. Smit, Ruben Boers, Jolanda Vaarwater, Joachim Boers, Tom Brands, Hanneke Mensink, Robert M. Verdijk, Wilfred F. J. van IJcken, Joost Gribnau, Annelies de Klein, Emine Kilic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Uveal melanoma (UM) is an aggressive intra-ocular cancer with a strong tendency to metastasize. Metastatic UM is associated with mutations in BAP1 and SF3B1, however only little is known about the epigenetic modifications that arise in metas
Externí odkaz:
https://doaj.org/article/917f2aa09fc549bf8c581c8646258bb0
Autor:
Christina Grosserichter-Wagener, Djawad Radjabzadeh, Hessel van der Weide, Kyra N. Smit, Robert Kraaij, John P. Hays, Menno C. van Zelm
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Changes in the intestinal microbiota have been associated with the development of immune-mediated diseases in humans. Additionally, the introduction of defined bacterial species into the mouse intestinal microbiota has been shown to impact on the ada
Externí odkaz:
https://doaj.org/article/879bea92b03e4432b320ba43a7fad51b
Autor:
Peter G Noordzij, Lisette M Vernooij, Olaf L Cremer, René N Idema, Henk JT Ruven, Ted Reniers, Maaike SY Thio, Nynke Hollema, Kyra N Smit, Ineke M Dijkstra, Thijs CD Rettig
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Purpose Postoperative complications increase mortality, disability and costs. Advanced understanding of the risk factors for postoperative complications is needed to improve surgical outcomes. This paper discusses the rationale and profile of the BIG
Externí odkaz:
https://doaj.org/article/006d96173ed04dd38a40c6ad4c28a3ac
Autor:
Wojtek Drabarek, Job van Riet, Josephine Q. N. Nguyen, Kyra N. Smit, Natasha M. van Poppelen, Rick Jansen, Eva Medico-Salsench, Jolanda Vaarwater, Frank J. Magielsen, Tom Brands, Bert Eussen, Thierry. P. P. van den Bosch, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Annelies de Klein, Erwin Brosens, Harmen J. G. van de Werken, Emine Kilic, on behalf of the Rotterdam Ocular Melanoma Study Group
Publikováno v:
Cancers, Vol 14, Iss 846, p 846 (2022)
Cancers; Volume 14; Issue 3; Pages: 846
Cancers, 14(3):846. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 3; Pages: 846
Cancers, 14(3):846. Multidisciplinary Digital Publishing Institute (MDPI)
Approximately 25% of all uveal melanoma (UM) contain driver mutations in the gene encoding the spliceosome factor SF3B1, and whilst patients with such SF3B1 mutations generally have an intermediate risk on developing metastatic disease, a third of th
Publikováno v:
Progress in Retinal and Eye Research, 75. PERGAMON-ELSEVIER SCIENCE LTD
Progress in Retinal and Eye Research, 75:100800. Elsevier Ltd.
Progress in Retinal and Eye Research, 75:100800. Elsevier Ltd.
Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye. Even if the primary tumor has been successfully treated with radiation or surgery, up to half of all UM patients will eventually develop metastatic disease. Despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fae6042803d10155b52f1c32f19803d
https://hdl.handle.net/1887/3182909
https://hdl.handle.net/1887/3182909
Autor:
Armin R. Afshar, Martine J. Jager, Helen Kalirai, Emine Kilic, Azzam Taktak, Natasha M. van Poppelen, Nikolaos E. Bechrakis, Rudolf F. Guthoff, Heinrich Heimann, Antonio Eleuteri, Sarah E. Coupland, Bertil Damato, Norbert Bornfeld, Claudia H. D. Le Guin, Laura J. Bonnett, Gregorius P M Luyten, Alexander Tsygankov, Vinodh Kakkassery, Carlo Mosci, Matthew Traynor, Mehmet Dogrusöz, Rumana Hussain, Silvia Viaggi, Paolo Ligorio, Marina Marinkovic, Christopher J. Hill, S.V. Saakyan, Björn O Scheef, Kyra N Smit, Alda Cunha Rola, Annelies de Klein
Publikováno v:
CANCERS
Cancers, Vol 12, Iss 2, p 477 (2020)
Cancers
Volume 12
Issue 2
Cancers, 12(2). MDPI
Cancers, 12. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 2, p 477 (2020)
Cancers
Volume 12
Issue 2
Cancers, 12(2). MDPI
Cancers, 12. Multidisciplinary Digital Publishing Institute (MDPI)
Uveal melanoma (UM) is fatal in ~50% of patients as a result of disseminated disease. This study aims to externally validate the Liverpool Uveal Melanoma Prognosticator Online V3 (LUMPO3) to determine its reliability in predicting survival after trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06d3106e1b55869592804a0e4b2450a
https://hdl.handle.net/1887/3182910
https://hdl.handle.net/1887/3182910
Autor:
Hessel van der Weide, John P. Hays, Kyra N Smit, Robert Kraaij, Menno C. van Zelm, Christina Grosserichter-Wagener, Djawad Radjabzadeh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology, 10:341. Frontiers Media S.A.
Frontiers in Immunology
Frontiers in Immunology, 10:341. Frontiers Media S.A.
Changes in the intestinal microbiota have been associated with the development of immune-mediated diseases in humans. Additionally, the introduction of defined bacterial species into the mouse intestinal microbiota has been shown to impact on the ada
Autor:
Kyra N Smit, Natasha M. van Poppelen, Emine Kilic, Jolanda Vaarwater, Wojtek Drabarek, Dion Paridaens, Tom Brands, Annelies de Klein
Publikováno v:
Cancers
Cancers, Vol 11, Iss 8, p 1200 (2019)
Cancers, 11(8):1200. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 11, Iss 8, p 1200 (2019)
Cancers, 11(8):1200. Multidisciplinary Digital Publishing Institute (MDPI)
Background: Uveal melanoma (UM) is the most common primary ocular malignancy in adults in the Western world. UM with a mutation in SF3B1, a spliceosome gene, is characterized by three or more structural changes of chromosome 1, 6, 8, 9, or 11. Also U
Autor:
Ronald van Marion, Helen Kalirai, Neil Farquhar, Annelies de Klein, Sarah E. Coupland, Hendrikus-Jan Dubbink, Kyra N Smit, Robert M. Verdijk, Dion Paridaens, Sophie Thornton, Jolanda Vaarwater, Emine Kilic, Natasha M. van Poppelen
Publikováno v:
MODERN PATHOLOGY
Modern Pathology, 31(5), 763-771. Nature Publishing Group
Modern Pathology, 31(5), 763-771. Nature Publishing Group
Uveal melanoma is a highly aggressive cancer of the eye, in which nearly 50% of the patients die from metastasis. It is the most common type of primary eye cancer in adults. Chromosome and mutation status have been shown to correlate with the disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b79d2397597f46d2a2cb0ee59a91c4
Autor:
Natasha M. van Poppelen, Dion Paridaens, Bert Eussen, Serdar Yavuzyigitoglu, Jolanda Vaarwater, Annelies de Klein, Tom Brands, Emine Kilic, Kyra N Smit
Publikováno v:
Genes, Chromosomes & Cancer
Genes Chromosomes & Cancer, 57(9), 452-458. Wiley-Liss Inc.
Genes Chromosomes & Cancer, 57(9), 452-458. Wiley-Liss Inc.
Uveal melanoma (UM) is the most common primary intraocular malignancy in the Western world. Recurrent mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, EIF1AX, and SF3B1 are described as well as non‐random chromosomal aberrations. Chromothripsis is a