'Student‐led workshop strengthens perceived discussion skills and community in an interdisciplinary graduate program'

Autor: Catharine Shipps, Kyra L. Thrush, Clorice R. Reinhardt, Sara A. Siwiecki, Jennifer L. Claydon, Dorottya B. Noble, Corey S. O'Hern

Publikováno v: FASEB BioAdvances, Vol 5, Iss 1, Pp 1-12 (2023)

Abstract The Integrated Graduate Program in Physical and Engineering Biology (IGPPEB) at Yale University brings together Ph.D. students from the physical, engineering, and biological sciences. The main goals of this program are for students to become

Externí odkaz: https://doaj.org/article/57d738515f454a92a7a8ca20b7ff1604

A computational solution for bolstering reliability of epigenetic clocks

Autor: Albert T. Higgins-Chen, Kyra L. Thrush, Yunzhang Wang, Christopher J. Minteer, Pei-Lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, Ann Zenobia Moore, Stefania Bandinelli, Christiaan H. Vinkers, Eric Vermetten, Bart P. F. Rutten, Elbert Geuze, Cynthia Okhuijsen-Pfeifer, Marte Z. van der Horst, Stefanie Schreiter, Stefan Gutwinski, Jurjen J. Luykx, Martin Picard, Luigi Ferrucci, Eileen M. Crimmins, Marco P. Boks, Sara Hägg, Tina T. Hu-Seliger, Morgan E. Levine

Publikováno v: Nature aging, 2(7), 644-661. Nature Publishing Group
Nature Aging, 2(7), 644-661. Springer
Higgins-Chen, A T, Thrush, K L, Wang, Y, Minteer, C J, Kuo, P-L, Wang, M, Niimi, P, Sturm, G, Lin, J, Moore, A Z, Bandinelli, S, Vinkers, C H, Vermetten, E, Rutten, B P F, Geuze, E, Okhuijsen-Pfeifer, C, van der Horst, M Z, Schreiter, S, Gutwinski, S, Luykx, J J, Picard, M, Ferrucci, L, Crimmins, E M, Boks, M P, Hägg, S, Hu-Seliger, T T & Levine, M E 2022, ' A computational solution for bolstering reliability of epigenetic clocks : implications for clinical trials and longitudinal tracking ', Nature Aging, vol. 2, no. 7, pp. 644-661 . https://doi.org/10.1038/s43587-022-00248-2

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show technical noise produces deviations up to 9 years between replicates for six prominent epigenetic cloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80161f5024c37e81348f4716caf1d3c4
https://doi.org/10.1038/s43587-022-00248-2

Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer's disease

Autor: Kyra L. Thrush, David A. Bennett, Christopher Gaiteri, Steve Horvath, Christopher H. van Dyck, Albert T. Higgins-Chen, Morgan E. Levine

Publikováno v: Aging. 14(14)

Alzheimer's disease (AD) risk increases exponentially with age and is associated with multiple molecular hallmarks of aging, one of which is epigenetic alterations. Epigenetic age predictors based on 5' cytosine methylation (DNAm), or epigenetic cloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c53b8e72a88b4817294a60a85a51d3
https://pubmed.ncbi.nlm.nih.gov/35907208

HCN, Formamidic Acid, and Formamide in Aqueous Solution: A Free-Energy Map

Autor: Jeremy Kua, Kyra L. Thrush

Publikováno v: The journal of physical chemistry. B. 120(33)

What chemical species might be found if water or ammonia reacts with HCN in aqueous solution under neutral conditions? Is it energetically favorable for formamidic acid, the first hydration product of HCN, to tautomerize into formamide under standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facce6ceedad904a59713bb9e0ef1b0d
https://pubmed.ncbi.nlm.nih.gov/27016454