Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Kyra L Jordan"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109650 (2014)
Human microRNAs (miRs) have been implicated in human diseases presumably through the downregulation and silencing of targeted genes via post-translational modifications. However, their role in the early stage of coronary atherosclerosis is not known.
Externí odkaz:
https://doaj.org/article/d1ac8e3a9b174823868c5e26e58aff59
Autor:
Yun Liang, Elif Ozdogan, Michael J. Hansen, Hui Tang, Ishran Saadiq, Kyra L. Jordan, James D. Krier, Deep B. Gandhi, Joseph P. Grande, Lilach O. Lerman, Timucin Taner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe immunomodulatory properties of mesenchymal stromal cells (MSC) have been well-characterized in in-vitro and in-vivo models. We have previously shown that liver MSC (L-MSC) are superior inhibitors of T-cell activation/proliferation, NK
Externí odkaz:
https://doaj.org/article/586a4f0a95384697991e199de658175c
Autor:
Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs). Mechanisms directing obesity-induced phenotypic alterations in
Externí odkaz:
https://doaj.org/article/6f680ad866984208b9f1e36b86773c4d
Autor:
Yamei Jiang, Siting Hong, Xiangyang Zhu, Lei Zhang, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Weijun Huang, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Extracellular vesicles (EVs) obtain properties of immunomodulation and tissue repair from their parental mesenchymal stem cells (MSCs), and upon delivery may be associated with fewer adverse events. EVs derived from adipose-tissue MSCs restored kidne
Externí odkaz:
https://doaj.org/article/2e78e514d09e47f0ad64ecef02f96341
Autor:
Mohsen Afarideh, Roman Thaler, Farzaneh Khani, Hui Tang, Kyra L. Jordan, Sabena M. Conley, Ishran M. Saadiq, Yasin Obeidat, Aditya S. Pawar, Alfonso Eirin, Xiang-Yang Zhu, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Publikováno v:
Epigenetics, Vol 16, Iss 7, Pp 705-717 (2021)
Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and paracrine function. Whether these adverse effects are mediated by chromatin-modifying epig
Externí odkaz:
https://doaj.org/article/2b3384506c554d2f9910f0914ae16396
Autor:
Kamalnath S. Rajagopalan, Sara Kazeminia, Logan M. Glasstetter, Rahele A. Farahani, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Alejandro R. Chade, Amir Lerman, Lilach O. Lerman, Alfonso Eirin
Publikováno v:
Cells, Vol 12, Iss 9, p 1274 (2023)
Autologous mesenchymal stem/stromal cells (MSCs) have demonstrated important therapeutic effects in several diseases. Cardiovascular risk factors may impair MSC mitochondrial structure and function, but the underlying mechanisms remain unknown. We hy
Externí odkaz:
https://doaj.org/article/3872a90fda1d46769770a21cfe0510f0
Autor:
Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may induce senescence in mesenchymal stem/stromal cells (MSC) and impact t
Externí odkaz:
https://doaj.org/article/3aee5cc0fdec4c1e9b6ab3f033b7131d
Autor:
Siting Hong, Ramyar Ghandriz, Sarosh Siddiqi, Xiang-Yang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Khaled A. Ali, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Cells, Vol 11, Iss 18, p 2891 (2022)
Autophagy eliminates excessive nutrients and maintains homeostasis. Obesity and metabolic syndrome (MetS) dysregulate autophagy, possibly partly due to mitochondria injury and inflammation. Elamipretide (ELAM) improves mitochondrial function. We hypo
Externí odkaz:
https://doaj.org/article/243b2e4845db4a2e92353998ce5a4901
Autor:
Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-3 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/ce495b3753b24996b470223f5faff3d3
Autor:
Alfonso Eirin, Yu Meng, Xiang-Yang Zhu, Yongxin Li, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Obesity is a chronic disease that interferes with normal repair processes, including adipose mesenchymal stem/stromal cells (ASCs) function. ASCs produce extracellular vesicles (EVs) that activate a repair program in recipient cells partly via their
Externí odkaz:
https://doaj.org/article/9efa2738a1164764b4b1a966cd95ed50