Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kyra E. de Goede"'
Autor:
Karl J. Harber, Annette E. Neele, Cindy PAA. van Roomen, Marion JJ. Gijbels, Linda Beckers, Myrthe den Toom, Bauke V. Schomakers, Daan AF. Heister, Lisa Willemsen, Guillermo R. Griffith, Kyra E. de Goede, Xanthe AMH. van Dierendonck, Myrthe E. Reiche, Aurélie Poli, Frida L-H Mogensen, Alessandro Michelucci, Sanne GS. Verberk, Helga de Vries, Michel van Weeghel, Jan Van den Bossche, Menno PJ. de Winther
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103054- (2024)
Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be
Externí odkaz:
https://doaj.org/article/7cec2f81eb784b929ea89dd94752aa37
Autor:
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intrace
Externí odkaz:
https://doaj.org/article/eedffe2b80ad4e5590a19202f028c287
Autor:
Martje N. Erkelens, Gera Goverse, Tanja Konijn, Rosalie Molenaar, Marieke R. Beijer, Jan Van den Bossche, Kyra E. de Goede, Sanne G. S. Verberk, Wouter J. de Jonge, Joke M. M. den Haan, Reina E. Mebius
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events suc
Externí odkaz:
https://doaj.org/article/7c1b2ccba2044b309c010d925ddfa5de
Publikováno v:
Biology, Vol 9, Iss 11, p 380 (2020)
Tumors consist of a wide variety of cells, including immune cells, that affect tumor progression. Macrophages are abundant innate immune cells in the tumor microenvironment (TME) and are crucial in regulating tumorigenicity. Specific metabolic condit
Externí odkaz:
https://doaj.org/article/e70ecc472d3d4508be1f5d7cce038b6c
Autor:
Karl J. Harber, Kyra E. de Goede, Sanne G. S. Verberk, Elisa Meinster, Helga E. de Vries, Michel van Weeghel, Menno P. J. de Winther, Jan Van den Bossche
Publikováno v:
Metabolites, Vol 10, Iss 9, p 372 (2020)
Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vas
Externí odkaz:
https://doaj.org/article/362e1315cbf4439eacd33d59b4a64102
Autor:
Kyra E. de Goede, Karl J. Harber, Friederike S. Gorki, Sanne G.S. Verberk, Laszlo A. Groh, Eelco D. Keuning, Eduard A. Struys, Michel van Weeghel, Arvand Haschemi, Menno P.J. de Winther, Xanthe A.M.H. van Dierendonck, Jan Van den Bossche
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease, 1868
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(9):166427. Elsevier
de Goede, K E, Harber, K J, Gorki, F S, Verberk, S G S, Groh, L A, Keuning, E D, Struys, E A, van Weeghel, M, Haschemi, A, de Winther, M P J, van Dierendonck, X A M H & van den Bossche, J 2022, ' D-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1868, no. 9, 166427 . https://doi.org/10.1016/j.bbadis.2022.166427
Biochimica et biophysica acta. Molecular basis of disease, 1868, 9
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1868(9):166427. Elsevier
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(9):166427. Elsevier
de Goede, K E, Harber, K J, Gorki, F S, Verberk, S G S, Groh, L A, Keuning, E D, Struys, E A, van Weeghel, M, Haschemi, A, de Winther, M P J, van Dierendonck, X A M H & van den Bossche, J 2022, ' D-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1868, no. 9, 166427 . https://doi.org/10.1016/j.bbadis.2022.166427
Biochimica et biophysica acta. Molecular basis of disease, 1868, 9
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1868(9):166427. Elsevier
Contains fulltext : 251502.pdf (Publisher’s version ) (Open Access) Macrophages undergo extensive metabolic rewiring upon activation which assist the cell in roles beyond energy production and synthesis of anabolic building blocks. So-called immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c480bd1717fb6bb688024b463114cb
http://hdl.handle.net/2066/251502
http://hdl.handle.net/2066/251502
Autor:
Sanne G.S. Verberk, Jeroen Baardman, Kyra E. de Goede, Jan Van den Bossche, Karl J Harber, Sjoerd T.T. Schetters, Menno P.J. de Winther, Yvette van Kooyk
Publikováno v:
Cancers
Volume 13
Issue 12
Cancers, 13(12):3054. Multidisciplinary Digital Publishing Institute (MDPI)
de Goede, K E, Verberk, S G S, Baardman, J, Harber, K J, van Kooyk, Y, de Winther, M P J, Schetters, S T T & Van den Bossche, J 2021, ' Myeloid-specific acly deletion alters macrophage phenotype in vitro and in vivo without affecting tumor growth ', Cancers, vol. 13, no. 12, 3054 . https://doi.org/10.3390/cancers13123054
Cancers, Vol 13, Iss 3054, p 3054 (2021)
Volume 13
Issue 12
Cancers, 13(12):3054. Multidisciplinary Digital Publishing Institute (MDPI)
de Goede, K E, Verberk, S G S, Baardman, J, Harber, K J, van Kooyk, Y, de Winther, M P J, Schetters, S T T & Van den Bossche, J 2021, ' Myeloid-specific acly deletion alters macrophage phenotype in vitro and in vivo without affecting tumor growth ', Cancers, vol. 13, no. 12, 3054 . https://doi.org/10.3390/cancers13123054
Cancers, Vol 13, Iss 3054, p 3054 (2021)
Simple Summary Tumor cells show different metabolism compared to normal tissue. For instance, they increase ATP-citrate lyase (Acly) expression for increased proliferation. Acly is therefore currently being targeted for cancer therapy. However, targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a1991a5e84036c057bf3eb5d6e4b65
Publikováno v:
Trends in cancer, 7(8), 666-667
van Dierendonck, X A M H, de Goede, K E & Van den Bossche, J 2021, ' IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate ', Trends in cancer, vol. 7, no. 8, pp. 666-667 . https://doi.org/10.1016/j.trecan.2021.06.003
Trends in cancer, 7(8), 666-667. Cell Press
van Dierendonck, X A M H, de Goede, K E & Van den Bossche, J 2021, ' IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate ', Trends in cancer, vol. 7, no. 8, pp. 666-667 . https://doi.org/10.1016/j.trecan.2021.06.003
Trends in cancer, 7(8), 666-667. Cell Press
Isocitrate dehydrogenase (IDH) mutations produce high levels of the ‘oncometabolite’ R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and progression of glioma tumors in the brain. A recent study in Nature Cancer by Friedrich e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde84a9ac80222c3a7805a1519dcbd7
https://pubmed.ncbi.nlm.nih.gov/34183306
https://pubmed.ncbi.nlm.nih.gov/34183306
Autor:
Friederike S. Gorki, Kyra E. de Goede, Jan Van den Bossche, Sanne Gs Verberk, Rafael J. Argüello, Xanthe A.M.H. van Dierendonck
Publikováno v:
SSRN Electronic Journal.
Macrophages are highly plastic immune cells that can adopt several activation states. Often, macrophages are stimulated in vitro with lipopolysaccharide (LPS) to elicit pro-inflammatory macrophages or interleukin (IL)-4 to obtain a homeostatic phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a5c97962a7d517a11a6fa84cfb5c0b
https://doi.org/10.2139/ssrn.3866832
https://doi.org/10.2139/ssrn.3866832
Publikováno v:
Biology
de Goede, K E, Driessen, A J M & Van den Bossche, J 2020, ' Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment ', Biology, vol. 9, no. 11, 380, pp. 1-17 . https://doi.org/10.3390/biology9110380
Biology, Vol 9, Iss 380, p 380 (2020)
de Goede, K E, Driessen, A J M & Van den Bossche, J 2020, ' Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment ', Biology, vol. 9, no. 11, 380, pp. 1-17 . https://doi.org/10.3390/biology9110380
Biology, Vol 9, Iss 380, p 380 (2020)
Simple Summary Tumors often include many immune cells that are theoretically able to combat tumor growth. Yet, tumors can induce immune functions that support tumor growth via different routes. In this review, we discuss how cancer cell metabolism re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73f4763762e49210fdca532993adf3
http://europepmc.org/articles/PMC7694986
http://europepmc.org/articles/PMC7694986