Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kyoungja Hong"'
Autor:
Xuefeng Zhang, Nyla Naim, Alejandro Pizzoni, Chao Qi, Kyoungja Hong, Volodymyr M. Korkhov, Daniel L. Altschuler
Publikováno v:
Proc Natl Acad Sci U S A
CAP1 (Cyclase-Associated Protein 1) is highly conserved in evolution. Originally identified in yeast as a bifunctional protein involved in Ras-adenylyl cyclase and F-actin dynamics regulation, the adenylyl cyclase component seems to be lost in mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2403fde8ee500ad9f574645085fab17f
https://europepmc.org/articles/PMC8214675/
https://europepmc.org/articles/PMC8214675/
Autor:
Salvatore J. Turco, Erica M. Selva, Kyoungja Hong, Norbert Perrimon, Gyeong Hun Baeg, Stephen M. Beverley, Udo Häcker
Publikováno v:
Nature Cell Biology. 3:809-815
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138a154a4d671072f2de9627960b5cce
https://doi.org/10.1038/ncb0901-809
https://doi.org/10.1038/ncb0901-809
Autor:
Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
Publikováno v:
Journal of medicinal chemistry. 56(20)
The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to three BIR domains that are crucial for their inhibitory function. The pro-survival properties of XIAP come from binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54996c22c1d8fb8749b427ec42349aeb
https://pubmed.ncbi.nlm.nih.gov/24093940
https://pubmed.ncbi.nlm.nih.gov/24093940
Autor:
Kang Le, Christophe Michoud, Robert T. Taylor, Christine Lukacs, Andrew D. Schutt, Lin Gao, Anthony Specian, Kenneth Carey Rupert, Stacy Remiszewski, Ann Polonskaia, Douglas Aguilar, Barry Goggin, John Anthony Moliterni, J. Heather Hogg, Liang Weiling, Xiaochun Han, Cheryl Janson, Louis J. Lombardo, Martin Weisel, Adrian J. Fretland, Steven Gregory Mischke, Norman Kong, Shirley Li, Robert Francis Kester, Andrew F. Donnell, Kyoungja Hong, Dave S. Solis, Karl Frank, Yan Lou
Publikováno v:
Journal of medicinal chemistry. 56(20)
XIAP is a key regulator of apoptosis, and its overexpression in cancer cells may contribute to their survival. The antiapoptotic function of XIAP derives from its BIR domains, which bind to and inhibit pro-apoptotic caspases. Most known IAP inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e48ef3b240f2787ad2fc864469665b6
https://pubmed.ncbi.nlm.nih.gov/24083782
https://pubmed.ncbi.nlm.nih.gov/24083782
Publikováno v:
The Journal of biological chemistry. 283(34)
Rap1b has been implicated in the transduction of the cAMP mitogenic signal. It is phosphorylated and activated by cAMP, and its expression in models where cAMP is mitogenic leads to proliferation and tumorigenesis. Akt is a likely downstream effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ae5b8f7d752eb25db8bbf5946ebb33
https://pubmed.ncbi.nlm.nih.gov/18550542
https://pubmed.ncbi.nlm.nih.gov/18550542
Autor:
Amy E. Sheehan, Kyoungja Hong, Michelle A. Avery, E. Richard Stanley, Marc R. Freeman, Jennifer S. Ziegenfuss, Yee Guide Yeung, Romi Biswas
Publikováno v:
Nature. 453(7197)
The cellular machinery promoting phagocytosis of corpses of apoptotic cells is well conserved from worms to mammals. An important component is the Caenorhabditis elegans engulfment receptor CED-1 (ref. 1) and its Drosophila orthologue, Draper2. The C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a97a5953b71e92437f4123754a6465
https://pubmed.ncbi.nlm.nih.gov/18432193
https://pubmed.ncbi.nlm.nih.gov/18432193
Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis
Autor:
Kyoungja Hong, Daniel Hochbaum, Guillermo Barila, Daniel L. Altschuler, Fernando Ribeiro-Neto
Publikováno v:
The Journal of biological chemistry. 283(8)
cAMP stimulates proliferation in many cell types. For many years, cAMP-dependent protein kinase (PKA) represented the only known cAMP effector. PKA, however, does not fully mimic the action of cAMP, indicating the existence of a PKA-independent compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4670a90fde27125e183e3f934d5cbfaf
https://pubmed.ncbi.nlm.nih.gov/18063584
https://pubmed.ncbi.nlm.nih.gov/18063584
Publikováno v:
Biochemistry. 39(8)
LPG2 (a gene involved in lipophosphoglycan assembly) encodes the Golgi GDP-Man transporter of the protozoan parasite Leishmania and is a defining member of a new family of eukaryotic nucleotide-sugar transporters (NSTs). Although NST activities are w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e03bed1a2bd594e1194fa327d980c48
https://pubmed.ncbi.nlm.nih.gov/10684651
https://pubmed.ncbi.nlm.nih.gov/10684651
Publikováno v:
Biochemical Society Transactions. 29:A42-A42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dbfde05e403d45e1366bff1694db2bd
https://doi.org/10.1042/bst029a042c
https://doi.org/10.1042/bst029a042c
Autor:
Kyoungja Hong1, Liguang Lou1, Gupta, Sandhya1, Ribeiro-Neto, Fernando1, Altschuler, Daniel L.1 altschul@pitt.edu
Publikováno v:
Journal of Biological Chemistry. 8/22/2008, Vol. 283 Issue 34, p23129-23138. 10p. 1 Black and White Photograph, 3 Charts, 3 Graphs.