Zobrazeno 1 - 10
of 563
pro vyhledávání: '"Kyoung Song"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2606 (2023)
Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules. This phenomenon, also known as the ‘Warburg effect,’ pro
Externí odkaz:
https://doaj.org/article/0d6b57a5a4534c78812370dc065ead1a
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6619-6627 (2020)
Externí odkaz:
https://doaj.org/article/ad1119d397f648089d7a7912645b6868
Autor:
Chan Gyu Lee, TaeEun Kim, Sungyoul Hong, Jongwan Chu, Ju Eun Kang, Hee Geon Park, Jun Young Choi, Kyoung Song, Sun Young Rha, Soohyeon Lee, Joon-Seok Choi, Sun Min Kim, Hae Min Jeong, Young Kee Shin
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Type I interferon (IFN) has been approved as an anticancer agent to treat some malignancies. However, IFNs have a short in vivo half-life, systemic toxicity, and poor biophysical properties, which prevent it from being widely used for cancer therapy.
Externí odkaz:
https://doaj.org/article/6c9e811c8b6e4038a696676a57153737
Autor:
Yu-Jin Kim, Gyunghwa Lee, Jinil Han, Kyoung Song, Joon-Seok Choi, Yoon-La Choi, Young Kee Shin
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
We previously showed that UBE2C mRNA expression is significantly associated with poor prognosis only in patients with hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2)– breast cancer. In this study, we further reanalyzed the co
Externí odkaz:
https://doaj.org/article/5a4a7b3ac4d548189d82670fdf5e65cd
Autor:
Kyoung Song, Nirmal Rajasekaran, Chaithanya Chelakkot, Hun Seok Lee, Seung-Mann Paek, Hobin Yang, Lina Jia, Hee Geon Park, Woo Sung Son, Yu-Jin Kim, Joon-Seok Choi, Hae Min Jeong, Young-Ger Suh, Hwayoung Yun, Young Kee Shin
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1060 (2021)
Aerobic glycolysis in cancer cells, also known as the Warburg effect, is an indispensable hallmark of cancer. This metabolic adaptation of cancer cells makes them remarkably different from normal cells; thus, inhibiting aerobic glycolysis is an attra
Externí odkaz:
https://doaj.org/article/a3cd02d1a0b14c19bfd1763848ecc314
Autor:
Nirmal Rajasekaran, Kyoung Song, Jin-Hee Lee, Yun Wei, Özgür Cem Erkin, Hunseok Lee, Young-Kee Shin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5595 (2021)
SMAD4, a key regulator of transforming growth factor-β (TGF-β) signaling, plays a major role in cell growth, migration, and apoptosis. In particular, TGF-β/SMAD induces growth arrest, and SMAD4 induces the expression of target genes such as p21WAF
Externí odkaz:
https://doaj.org/article/dac5a3fef66845329ef7f5cf56577e81
Autor:
Mi Jeong Kwon, Jeong Eon Lee, Joon Jeong, Sang Uk Woo, Jinil Han, Byeong-il Kang, Jee-Eun Kim, Youngho Moon, Sae Byul Lee, Seonghoon Lee, Yoon-La Choi, Youngmi Kwon, Kyoung Song, Gyungyub Gong, Young Kee Shin
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Introduction: The GenesWell Breast Cancer Test (BCT) is a recently developed multigene assay that predicts the risk of distant recurrence in patients with early breast cancer. Here, we analyzed the concordance of the BCT score with the Oncotype DX re
Externí odkaz:
https://doaj.org/article/6feae497790142749bad1644f59a591b
Autor:
Saehyung Lee, Woo Sung Son, Ho Bin Yang, Nirmal Rajasekaran, Sung-Su Kim, Sungyoul Hong, Joon-Seok Choi, Jun Young Choi, Kyoung Song, Young Kee Shin
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I in
Externí odkaz:
https://doaj.org/article/84282aa384e34d00b618008b96b0d5fb
Autor:
Chaithanya Chelakkot, Jiyeon Ryu, Mi Young Kim, Jin-Soo Kim, Dohyeong Kim, Juhyun Hwang, Sung Hoon Park, Seok Bum Ko, Jeong Won Park, Moon Youn Jung, Ryong Nam Kim, Kyoung Song, Yu Jin Kim, Yoon-La Choi, Hun Seok Lee, Young Kee Shin
Publikováno v:
Micromachines, Vol 11, Iss 6, p 560 (2020)
Here, we validated the clinical utility of our previously developed microfluidic device, GenoCTC, which is based on bottom magnetophoresis, for the isolation of circulating tumor cells (CTCs) from patient whole blood. GenoCTC allowed 90% purity, 77%
Externí odkaz:
https://doaj.org/article/bf6f2d2a4e8c4167b093210be92d5ba4
Autor:
Hobin Yang, Hayeon Park, Yong Jin Lee, Jun Young Choi, TaeEun Kim, Nirmal Rajasekaran, Saehyung Lee, Kyoung Song, Sungyoul Hong, Joon-Seok Choi, Hyunbo Shim, Young-Deug Kim, Soohyun Hwang, Yoon-La Choi, Young Kee Shin
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 51 (2019)
Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell−cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during tum
Externí odkaz:
https://doaj.org/article/4c94c1650f514e20bb65a9d3a56fb328