Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kyoung S. Kim"'
Publikováno v:
Journal of Astronomy and Space Sciences, Vol 13, Iss 2, Pp 198-209 (1996)
In this paper, we present an image compression algorithm that is capable of significantly reducing the vast mount of information contained in multispectral images. The developed algorithm exploits the spectral and spatial correlations found in multis
Externí odkaz:
https://doaj.org/article/10fc94b293cc421c8e7e90622959a2c8
Autor:
Charu Chaudhry, Ping Zhang, Kyoung S. Kim, William J. Pitts, Cornelius Lyndon A M, Lynn M. Abell, Hart Amy C, Kevin O’Malley, Junqing Guo, Brian Carpenter, Hao Lu, Ramesh Padmanabha, Patrick J. Shaw, Mertzman Michael E, Kevin Kish, Andrew E Douglas, Matthew Pokross, John E. Macor, Deepa Calambur, Carolyn A. Weigelt
Publikováno v:
ACS Med Chem Lett
[Image: see text] Necroptosis has been implicated in a variety of disease states, and RIPK3 is one of the kinases identified to play a critical role in this signaling pathway. In an effort to identify RIPK3 kinase inhibitors with a novel profile, mec
Autor:
Liping Zhang, Andrew J. Tebben, Chunhong Yan, Mian Gao, Maxim Ruzanov, Dianlin Xie, Hao Lu, Susan E. Kiefer, Lisa M. Kopcho, Kyoung S. Kim, John A. Newitt, Steven Sheriff
Publikováno v:
Acta Crystallographica Section D Structural Biology. 72:658-674
The cytokine TGF-β modulates a number of cellular activities and plays a critical role in development, hemostasis and physiology, as well as in diseases including cancer and fibrosis. TGF-β signals through two transmembrane serine/threonine kinase
Autor:
Yong Zhang, Ming Lei, Shana L. Posy, Kyoung S. Kim, Benjamin A. Seigal, Joseph Fargnoli, Stuart Emanuel, Percy H. Carter, Nicholas K. Terrett, Neha Surti, Robert M. Borzilleri, Henry Shen, Joseph G. Naglich, Matthew Pokross, Randy Talbott, Andrew Fraley, William H. Connors
Publikováno v:
Journal of Medicinal Chemistry. 58:2855-2861
Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic caspases. X-ray cocrystal structures of key compounds with XIAP BIR2 suggeste
Autor:
Gregory D. Vite, Randy Talbott, Joseph G. Naglich, Caroline Fanslau, Jinping Gan, Donna D. Wei, Charu Chaudhry, Joseph Fargnoli, Kyoung S. Kim, Robert M. Borzilleri, Ming Lei, Ragini Vuppugalla, Stuart Emanuel, Sarah C. Traeger, Heidi L. Perez
Publikováno v:
Journal of Medicinal Chemistry. 58:1556-1562
The prominent role of IAPs in controlling cell death and their overexpression in a variety of cancers has prompted the development of IAP antagonists as potential antitumor therapies. We describe the identification of a series of heterodimeric antago
Autor:
Robert J. Schmidt, Benjamin J. Henley, Celia D’Arienzo, Jonathan Lippy, John S. Sack, Yueping Zhang, Yongmi An, John T. Hunt, Amrita Kamath, John S. Tokarski, Barri Wautlet, Veeraswamy Manne, Dianlin Xie, Punit Marathe, Donna D. Wei, Louis J. Lombardo, Kyoung S. Kim, Robert Jeyaseelan, David K. Williams, Joseph Fargnoli, Liping Zhang, Yaquan Zhang, Johnni Gullo-Brown, Zhen-Wei Cai, George L. Trainor, Robert M. Borzilleri
Publikováno v:
Journal of Medicinal Chemistry. 51:5330-5341
Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to potent 4-pyridone and pyridine N-oxide inhibitors such as 3 and 4. T
Autor:
Amrita Kamath, Yongmi An, John T. Hunt, Punit Marathe, Veeraswamy Manne, Zhen-Wei Cai, Donna D. Wei, John S. Sack, Robert J. Schmidt, Yueping Zhang, Robert M. Borzilleri, Kyoung S. Kim, Cornelius Lyndon A M, Gretchen M. Schroeder, David K. Williams, Xiao-Tao Chen, Joseph Fargnoli, Louis J. Lombardo, John S. Tokarski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3224-3229
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the dis
Autor:
Rawlins David B, Kevin R. Webster, Michael A. Poss, Chieh Ying Chang, Roberta Batorsky, Craig R. Fairchild, Toomas Mitt, Weifang Shan, Kristen A. Kellar, Hai Yun Xiao, John S. Tokarski, John T. Hunt, Francis Y. Lee, Janet G. Mulheron, Kyoung S. Kim, Nikola P. Pavletich, David Bol, Amrita Kamath, John S. Sack, Urvashi V. Roongta, Zhen Wei Cai, Isia Bursuker, Raj N. Misra, William G. Humphreys, Songfeng Lu, Wen Ching Han, Punit Marathe, S. David Kimball, Hong Zhu, Ligang Qian
Publikováno v:
Journal of Medicinal Chemistry. 45:3905-3927
High throughput screening identified 2-acetamido-thiazolylthio acetic ester 1 as an inhibitor of cyclin-dependent kinase 2 (CDK2). Because this compound is inactive in cells and unstable in plasma, we have stabilized it to metabolic hydrolysis by rep
Autor:
David K. Williams, Charu Chaudhry, Robert M. Borzilleri, Liping Zhang, Randy Talbott, Kyoung S. Kim, Erik M. Stang, Ming Lei, Heidi L. Perez, Shana L. Posy, Stuart Emanuel
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(21)
Bivalent heterodimeric IAP antagonists that incorporate (R)-tetrahydroisoquinoline in the P3′ subunit show high affinity for the BIR2 domain and demonstrated potent IAP inhibitory activities in biochemical and cellular assays. Potent in vivo effica
Autor:
Raj N. Misra, William G. Humphreys, K R Webster, John S. Sack, Y. F. Kelly, Janet G. Mulheron, Kimball Sd, Ligang Qian, Sam T. Chao, Kyoung S. Kim, Leslie Leith, John T. Hunt, Barri Wautlet, John S. Tokarski
Publikováno v:
Journal of Medicinal Chemistry. 43:4126-4134
Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130