Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kyouhei Hayashi"'
Autor:
Kyouhei Hayashi, Hiroki Sato, Hirohide Nambu, Kana Watanabe, Hideo Yukioka, Takayuki Okuno, Nobuyuki Tanaka, Masahiko Fujioka, Akira Yukimasa, Yukari Tanaka, Takeshi Chiba, Hideki Tanioka, Naoki Omori, Tamura Yuusuke, Naoki Kouyama, Yuji Nishiura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:90-95
Optimization of HTS hit 1 for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study. Among them, derivative 4i inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ed5cd8b86ffba1bcadee2752058f6d
https://doi.org/10.1016/j.bmcl.2012.11.005
https://doi.org/10.1016/j.bmcl.2012.11.005
Autor:
Kyouhei Hayashi, Kana Watanabe, Tamura Yuusuke, Takayuki Okuno, Naoki Kouyama, Yukari Tanaka, Takeshi Chiba, Hiroki Sato, Yuji Nishiura, Naoki Omori, Hideo Yukioka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5498-5502
Optimization of our HTS hit 1, mainly focused on modification at the C-2 position of the benzimidazole core, is described. Elimination of the flexible and metabolically labile -S-CH(2)- part and utilization of less lipophilic pyridone substructure le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1455f57e335f696ddc58dbfe28f1dea4
https://doi.org/10.1016/j.bmcl.2012.07.020
https://doi.org/10.1016/j.bmcl.2012.07.020
Publikováno v:
The Review of scientific instruments. 85(2)
Electron-ionization-type polyatomic molecular ion source with low fragment was developed by using a pair of ring-shaped Sm-Co magnets. The magnets were placed forward and backward side of ionization part to confine electrons extracted from a thermion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdbaccb07608eb0ec96f47d4733034a
https://pubmed.ncbi.nlm.nih.gov/24593425
https://pubmed.ncbi.nlm.nih.gov/24593425
Autor:
Kyouhei Hayashi, Yuji Nishiura, Kana Watanabe, Tamura Yuusuke, Takayuki Okuno, Yukari Tanaka, Takeshi Chiba, Hiroki Sato, Naoki Omori, Hideo Yukioka, Naoki Kouyama
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
Optimization of lead compound 2 is described, mainly focusing on modification at the C-2 position of the benzimidazole core. Replacement of the phenyl linker of 2 with saturated rings resulted in identification of compound 8b which combines high Y5 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050ba4b4bce8bd4e4f9bb7a339c4b513
https://pubmed.ncbi.nlm.nih.gov/23025998
https://pubmed.ncbi.nlm.nih.gov/23025998
Autor:
Eiji Yamanaka, Akira Higuchi, Naoya Hayashi, Kyouhei Hayashi, Kusuo Ueno, Masaya Kato, Masamitsu Itoh
Publikováno v:
SPIE Proceedings.
Optical proximity correction (OPC) is still an essential technology for critical dimension (CD) control in Extreme Ultra Violet (EUV) lithography. For quality assurance of EUV mask pattern, a metrology of complicated two-dimensional (2D) OPC patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9892cdf04bb0707e634d3c67a4499180
https://doi.org/10.1117/12.868631
https://doi.org/10.1117/12.868631
Autor:
Akio Kobayashi, Kyouhei Hayashi, Minetaka Sugiyama, Masafumi Nishizawa, Kiichi Fukui, Satoshi Harashima, Yoshinobu Kaneko
Publikováno v:
Journal of bioscience and bioengineering. 96(4)
We have previously developed a chromosome-splitting technique based on homologous recombination in Saccharomyces cerevisiae. To facilitate chromosome splitting at multiple sites, we focused on the delta sequences that are distributed in more than 200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026dabacb45f964d3672d3a665822951
https://pubmed.ncbi.nlm.nih.gov/16233544
https://pubmed.ncbi.nlm.nih.gov/16233544
Publikováno v:
Review of Scientific Instruments; 2014, Vol. 85 Issue 2, p1-3, 3p, 2 Diagrams, 1 Chart, 3 Graphs