Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kyotaka Muta"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3141 (2019)
Drug-induced liver injury (DILI) is one of the most serious and frequent drug-related adverse events in humans. Selenium (Se) and glutathione (GSH) have a crucial role for the hepatoprotective effect against reactive metabolites or oxidative damage l
Externí odkaz:
https://doaj.org/article/98121a3ca0c84f68acf34d2e9a156c96
Autor:
Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai
Publikováno v:
Journal of applied toxicology : JAT. 42(9)
Ethionamide (ETH), a second-line drug for multidrug-resistant tuberculosis, is known to cause hepatic steatosis in rats and humans. To investigate predictive biomarkers for ETH-induced steatosis, we performed lipidomics analysis using plasma and live
Autor:
Hideaki Yokoyama, Eiji Murata, Fumihiro Jinno, Harumi Kitaura, Atsushi Iwai, Yoshiro Saito, Kyotaka Muta, Norimichi Hattori, Kosuke Saito, Kanae Mori, Hirohiko Ohtsuka, Akio Kobayashi, Asuka Takumi, Keiko Nakai
Publikováno v:
The Journal of Toxicological Sciences. 45:319-325
Due to finalization of the ICH S3A Q&A focusing on microsampling, application of microsampling technique to regular non-clinical animal studies is expected for non-clinical safety assessment of pharmaceuticals. In Europe, microsampling from the tail
Autor:
Yuzo Yasui, Anindya Hajra, Ameya Deshpande, Kyotaka Muta, Toshiyuki Shoda, Naohito Yamada, Tijo Thomas, Taishi Shimazaki
Publikováno v:
Journal of toxicologic pathology. 35(2)
Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this paper, we present an AI-based solution for preclinical toxicology studies. We trained a set
Publikováno v:
The Journal of toxicological sciences. 43(6)
Valproic acid (VPA) is known to induce hepatic steatosis due to mitochondrial toxicity in rodents and humans. In the present study, we administered VPA to SD rats for 3 or 14 days at 250 and 500 mg/kg and then performed lipidomics analysis to reveal
Autor:
Toshiyuki Shoda, Akio Kobayashi, Taku Masuyama, Kaoru Toyoda, Kochi Kakimoto, Kyotaka Muta, Shoichiro Sugai, Yusuke Suzuki
Publikováno v:
The Journal of toxicological sciences. 43(1)
Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3141 (2019)
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3141 (2019)
Volume 20
Issue 13
Drug-induced liver injury (DILI) is one of the most serious and frequent drug-related adverse events in humans. Selenium (Se) and glutathione (GSH) have a crucial role for the hepatoprotective effect against reactive metabolites or oxidative damage l
Publikováno v:
Biochemical pharmacology. 98(4)
Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to diacetolol. Because metabolic activation has been considered to be related to acebutolol-induced toxicity,
Publikováno v:
Biochemical pharmacology. 87(2)
Human arylacetamide deacetylase (AADAC) can hydrolyze clinical drugs such as flutamide, phenacetin, and rifamycins. AADAC is a glycoprotein, but the role of glycosylation remains unclear. In the present study, we investigated the effect of glycosylat
Autor:
Keisuke Goda1 keisuke.goda@jt.com, Kosuke Saito2, Kyotaka Muta1, Akio Kobayashi1, Yoshiro Saito2, Shoichiro Sugai1
Publikováno v:
Journal of Toxicological Sciences. 2018, Vol. 43 Issue 6, p395-405. 11p.