Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kyota Fujita"'
Autor:
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Better understanding of the earliest molecular pathologies of all neurodegenerative diseases is expected to improve human therapeutics. We investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial
Externí odkaz:
https://doaj.org/article/2b5f357966984137a40f33a05396b619
Autor:
Yuki Yoshioka, Juliana Bosso Taniguchi, Hidenori Homma, Takuya Tamura, Kyota Fujita, Maiko Inotsume, Kazuhiko Tagawa, Kazuharu Misawa, Naomichi Matsumoto, Masanori Nakagawa, Haruhisa Inoue, Hikari Tanaka, Hitoshi Okazawa
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-15 (2023)
Abstract Background Charcot-Marie-Tooth disease type 1A (CMT1A) is one of the most common hereditary peripheral neuropathies caused by duplication of 1.5 Mb genome region including PMP22 gene. We aimed to correct the duplication in human CMT1A patien
Externí odkaz:
https://doaj.org/article/b04c0feb3d2348619d68df90a185af7f
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3636 (2024)
The mechanisms of neuronal cell death in neurodegenerative disease remain incompletely understood, although recent studies have made significant advances. Apoptosis was previously considered to be the only mechanism of neuronal cell death in neurodeg
Externí odkaz:
https://doaj.org/article/cc478e57bd2540b78cdcde0815e16ac9
Autor:
Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stres
Externí odkaz:
https://doaj.org/article/541954025d9d42c8b967b6b96a1b4020
Autor:
Kyota Fujita, Hidenori Homma, Meihua Jin, Yuki Yoshioka, Xiaocen Jin, Yuko Saito, Hikari Tanaka, Hitoshi Okazawa
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112962- (2023)
Summary: Prion-like protein propagation is considered a common pathogenic mechanism in neurodegenerative diseases. Here we investigate the in vivo propagation pattern and aggregation state of mutant α-synuclein by injecting adeno-associated viral (A
Externí odkaz:
https://doaj.org/article/5beae43f6fbf436a940da83fd9dedfcc
Autor:
Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune res
Externí odkaz:
https://doaj.org/article/a6f77446056c4920834d3c51e49c5a27
Autor:
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD,
Externí odkaz:
https://doaj.org/article/fd80c0c5e83d4543afa38997ad8b886c
Autor:
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Jin et al use dynamic molecular network analysis to characterise the phosphoproteome in mouse models of neurodegenerative disease. Analyzing four models of frontotemporal lobar degeneration and four models of Alzheimer’s disease, they observe conse
Externí odkaz:
https://doaj.org/article/d5e02764078f40b4a23cb0a281d050c6
Autor:
Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-ichi Muramatsu, Hideyuki Okano, Elliott J. Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis re
Externí odkaz:
https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd
Autor:
Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Progranulin (PGRN) mutations cause frontotemporal lobe dementia with TDP-43 pathology. Here the authors develop a mutant PGRN knock-in mouse model of the disease, and show that Tyro3, a tyrosine kinase membrane receptor that acts upstream of PKC and
Externí odkaz:
https://doaj.org/article/09ed0cd6cc5041bf8759b3550eb3f80b