Zobrazeno 1 - 10
of 372
pro vyhledávání: '"Kyong-Tai Kim"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Prostate cancer is the most prevalent cancer in men worldwide and is promoted by the sex hormone androgen. Expression of androgen from the testis can be significantly reduced through castration. However, as most prostate cancer patients acqu
Externí odkaz:
https://doaj.org/article/ed92867a4c03464b8bea4d52f83a0523
Autor:
Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung
Publikováno v:
Diabetes & Metabolism Journal, Vol 47, Iss 5, Pp 653-667 (2023)
Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated. Methods KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a prev
Externí odkaz:
https://doaj.org/article/91fb5259262c4b9db1117c6fff669cf2
Autor:
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
Externí odkaz:
https://doaj.org/article/3a702a1ed24a45f995d55ea263c1b376
Autor:
Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Kim
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background Microglia are the resident immune cells found in our brain. They have a critical role in brain maintenance. Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Aβ. Through
Externí odkaz:
https://doaj.org/article/96eaa894936b464f81e2061e60ae998b
Autor:
Eunji Oh, Hyo Jin Kim, Dohyun Lee, Jeong Hwa Kang, Hyung Geun Kim, Seung Hyun Han, Nam In Baek, Kyong-Tai Kim
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113272- (2022)
Microphthalmia-associated transcription factor (MITF) is highly expressed in melanocytes and is the main regulator of melanogenesis and melanocyte cell fate. Although MITF is important for the differentiation and development of melanocytes, it is als
Externí odkaz:
https://doaj.org/article/39c0418ca9be4bbe9cb8fc958fc6cf31
Publikováno v:
Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)
Abstract Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant succe
Externí odkaz:
https://doaj.org/article/1f885df3ff9b46fb828d8ab17a006f25
Publikováno v:
Cells, Vol 11, Iss 12, p 1902 (2022)
Although different regions of the brain are dedicated to specific functions, the intra- and inter-regional heterogeneity of astrocytes and microglia in these regions has not yet been fully understood. Recently, an advancement in various technologies,
Externí odkaz:
https://doaj.org/article/8dff46ed13574e809fe313b5e31d2241
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1265 (2022)
Flavonoids are being increasingly applied for the treatment of various diseases due to their anti-cancer, anti-oxidant, anti-inflammatory, and anti-viral properties. However, it is often challenging to detect their presence in cells and tissues throu
Externí odkaz:
https://doaj.org/article/a3e9d3eff8014eccbbc050a14347e25c
Publikováno v:
Cells, Vol 10, Iss 12, p 3567 (2021)
Protein aggregates of cofilin and actin have been found in neurons under oxygen–glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen–glucose deprivation remains unclear. Here, we found that heterogene
Externí odkaz:
https://doaj.org/article/d67d5b1c031d41f1b6859e93030004ba
Autor:
Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong-Hoon Kim, Jong Hyuk Yoon, Seon-Min Park, Seung-Jae V. Lee, In-Kyu Lee, Kwan Yong Choi, Sung Ho Ryu, Kazunari Nohara, Seung-Hee Yoo, Zheng Chen, Kyong-Tai Kim
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested wh
Externí odkaz:
https://doaj.org/article/10201d00788242438ead92d92999e6dd